Androvax

{{Short description|Vaccine}}

{{Drugbox

| type = combo

| drug_name =

| component1 = Androstendione

| class1 = Androstane steroid

| component2 = Human serum albumin

| class2 = Serum protein

| tradename = Androvax

| Drugs.com = {{drugs.com|monograph|estrogen-progestin-combinations}}

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| pregnancy_US = X

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| legal_US = Rx-only

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| CAS_number = 128280-53-5

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| ATCvet =

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| synonyms = Androstenedione:human serum albumin conjugate

}}

Androvax, also known as androstenedione:human serum albumin conjugate, is an immunogen and vaccine against androstenedione that is used in veterinary medicine to increase the ovulation rate and number of lambs born to ewes.{{cite book| vauthors = Jindal SK, Sharma MC |title=Biotechnology in Animal Health and Production|url=https://books.google.com/books?id=e9yFom2LWTcC&pg=PA77|year=2010|publisher=New India Publishing|isbn=978-93-80235-35-6|pages=77–}}{{cite book|title=Reproductive Technologies in Farm Animals|url=https://books.google.com/books?id=rItfbxpris0C&pg=PA206|year=2004|publisher=CABI|isbn=978-0-85199-049-1|pages=206–}}{{cite web | url = https://www.msd-animal-health.co.nz/wp-content/uploads/sites/39/2020/02/Androvax_Plus_Website_label_July_2013_tcm51-36690.pdf | title = Androvax Label | work = Schering-Plough Animal Health Ltd | publisher = MSD Animal Health }} It is a conjugate of androstenedione and human serum albumin. The drug is marketed in New Zealand.

Androvax produces immunity against androstenedione, and the generation of antibodies against androstenedione decreases circulating levels of androstenedione. In addition, since androstenedione is the major precursor of estrogens, estrogen levels are decreased as well. This is thought to result in reduced negative feedback on the hypothalamic-pituitary-gonadal axis and increased gonadotropin secretion, which in turn improves fertility and fecundity.