Anti-nRNP

{{Short description|Autoantibody}}

Anti-nRNP is a type of antibody.{{cite journal |vauthors=Migliorini P, Baldini C, Rocchi V, Bombardieri S |title=Anti-Sm and anti-RNP antibodies |journal=Autoimmunity |volume=38 |issue=1 |pages=47–54 |date=February 2005 |pmid=15804705 |doi=10.1080/08916930400022715 }}{{cite journal |vauthors=Brennan FM, Andrew EM, Williams DG, Maini RN |title=Anti-nRNP anti-nuclear antibody-secreting cells are represented in the B-lymphocyte repertoire of normal and MRL/MP-lpr/lpr lupus mice |journal=Immunology |volume=63 |issue=2 |pages=213–7 |date=February 1988 |pmid=3258271 |pmc=1454531 }}

They are autoantibodies against some ribonucleoproteins.{{cite journal |vauthors=Satoh M, Richards HB, Hamilton KJ, Reeves WH |title=Human anti-nuclear ribonucleoprotein antigen autoimmune sera contain a novel subset of autoantibodies that stabilizes the molecular interaction of U1RNP-C protein with the Sm core proteins |journal=J. Immunol. |volume=158 |issue=10 |pages=5017–25 |date=May 1997 |pmid=9144522 |url=http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=9144522}}

Anti-nRNP antibodies can be elevated in mixed connective tissue disease.{{cite journal |vauthors=Negoro N, Kanayama Y, Takeda T, Koda S, Inoue T |title=A solid-phase radioimmunoassay for the detection of nRNP immune complexes |journal=J. Immunol. Methods |volume=91 |issue=1 |pages=83–9 |date=July 1986 |pmid=3722833 |doi= 10.1016/0022-1759(86)90105-5}}