BAG4

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost.

BAG4 has been shown to interact with:

• APOBEC1,{{cite journal | date = Dec 2003 |vauthors=Lau PP, Chan L | title = Involvement of a chaperone regulator, Bcl2-associated athanogene-4, in apolipoprotein B mRNA editing | journal = J. Biol. Chem. | volume = 278 | issue = 52 | pages = 52988–96 | pmid = 14559896 | doi = 10.1074/jbc.M310153200| doi-access = free }}
• HSPA8,{{cite journal | date = Apr 2002 |vauthors=Miki K, Eddy EM | title = Tumor necrosis factor receptor 1 is an ATPase regulated by silencer of death domain | journal = Mol. Cell. Biol. | volume = 22 | issue = 8 | pages = 2536–43 | pmid = 11909948 | pmc = 133739 | doi = 10.1128/MCB.22.8.2536-2543.2002}} and
• TNFRSF1A.

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• {{UCSC gene info|BAG4}}

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• {{cite journal | author=Riley BM |title=A Genome-Wide Linkage Scan for Cleft Lip and Cleft Palate Identifies a Novel Locus on 8p11-23 |journal=Am. J. Med. Genet. A |volume=143 |issue= 8 |pages= 846–52 |year= 2007 |pmid= 17366557 |doi= 10.1002/ajmg.a.31673 | pmc=2570349 |name-list-style=vanc| author2=Schultz RE | author3=Cooper ME | display-authors=3 | last4=Goldstein-Mchenry | first4=T. | last5=Daack-Hirsch | first5=S. | last6=Lee | first6=K.T. | last7=Dragan | first7=E. | last8=Vieira | first8=A.R. | last9=Lidral | first9=A.C. }}
• {{cite journal | author=Yang ZQ |title=Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer |journal=Cancer Res. |volume=66 |issue= 24 |pages= 11632–43 |year= 2007 |pmid= 17178857 |doi= 10.1158/0008-5472.CAN-06-2946 |name-list-style=vanc| author2=Streicher KL | author3=Ray ME | display-authors=3 | last4=Abrams | first4=J. | last5=Ethier | first5=S. P. |doi-access=free }}
• {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
• {{cite journal |vauthors=Lau PP, Chan L |title=Involvement of a chaperone regulator, Bcl2-associated athanogene-4, in apolipoprotein B mRNA editing |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52988–96 |year= 2004 |pmid= 14559896 |doi= 10.1074/jbc.M310153200 |doi-access= free }}
• {{cite journal | author=Al-Lamki RS |title=Expression of Silencer of Death Domains and Death-Receptor-3 in Normal Human Kidney and in Rejecting Renal Transplants |journal=Am. J. Pathol. |volume=163 |issue= 2 |pages= 401–11 |year= 2003 |pmid= 12875962 |doi= 10.1016/S0002-9440(10)63670-X| pmc=1868232 |name-list-style=vanc| author2=Wang J | author3=Thiru S | display-authors=3 | last4=Pritchard | first4=NR | last5=Bradley | first5=JA | last6=Pober | first6=JS | last7=Bradley | first7=JR }}
• {{cite journal |vauthors=Eichholtz-Wirth H, Fritz E, Wolz L |title=Overexpression of the 'silencer of death domain', SODD/BAG-4, modulates both TNFR1- and CD95-dependent cell death pathways |journal=Cancer Lett. |volume=194 |issue= 1 |pages= 81–9 |year= 2003 |pmid= 12706861 |doi=10.1016/S0304-3835(03)00009-0 }}
• {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
• {{cite journal | author=Briknarová K |title=BAG4/SODD protein contains a short BAG domain |journal=J. Biol. Chem. |volume=277 |issue= 34 |pages= 31172–8 |year= 2002 |pmid= 12058034 |doi= 10.1074/jbc.M202792200 |name-list-style=vanc| author2=Takayama S | author3=Homma S | display-authors=3 | last4=Baker | first4=K | last5=Cabezas | first5=E | last6=Hoyt | first6=DW | last7=Li | first7=Z | last8=Satterthwait | first8=AC | last9=Ely | first9=KR | doi-access=free }}
• {{cite journal |vauthors=Eichholtz-Wirth H, Sagan D |title=Altered signaling of TNFalpha-TNFR1 and SODD/BAG4 is responsible for radioresistance in human HT-R15 cells |journal=Anticancer Res. |volume=22 |issue= 1A |pages= 235–40 |year= 2002 |pmid= 12017295 }}
• {{cite journal | author=Antoku K |title=Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein |journal=Biochem. Biophys. Res. Commun. |volume=286 |issue= 5 |pages= 1003–10 |year= 2001 |pmid= 11527400 |doi= 10.1006/bbrc.2001.5512 |name-list-style=vanc| author2=Maser RS | author3=Scully WJ | display-authors=3 | last4=Delach | first4=Scott M. | last5=Johnson | first5=Daniel E. }}
• {{cite journal | author=Frisch SM |title=Evidence for a function of death-receptor-related, death-domain-containing proteins in anoikis |journal=Curr. Biol. |volume=9 |issue= 18 |pages= 1047–9 |year= 2000 |pmid= 10508612 |doi=10.1016/S0960-9822(99)80455-2 |s2cid=17212216 |doi-access=free }}

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Category:Co-chaperones