BRCT domain

{{Infobox protein family

| Symbol = BRCT

| Name = BRCA1 C Terminus (BRCT) domain

| image = PDB_1cdz_EBI.jpg

| width =

| caption = Structure of an XRCC1 BRCT domain.{{cite journal |vauthors=Zhang X, Moréra S, Bates PA |title=Structure of an XRCC1 BRCT domain: a new protein-protein interaction module |journal=EMBO J. |volume=17 |issue=21 |pages=6404–11 |date=November 1998 |pmid=9799248 |pmc=1170965 |doi=10.1093/emboj/17.21.6404 |display-authors=etal}}

| Pfam= PF00533

| InterPro= IPR001357

| SMART=

| Prosite =

| SCOP = 1cdz

| TCDB =

| OPM family=

| OPM protein=

| CDD = cd00027

| PDB=

{{PDB3|2azm}}B:1906-1957 {{PDB3|2ado}}B:1906-1957 {{PDB3|2etx}}A:1906-1957

{{PDB3|1kzy}}C:1795-1835 {{PDB3|1l0b}}A:1589-1669 {{PDB3|1t2v}}C:1646-1723

{{PDB3|1n5o}}X:1646-1723 {{PDB3|1t2u}}A:1646-1723 {{PDB3|1jnx}}X:1646-1723

{{PDB3|1t15}}A:1646-1723 {{PDB3|1t29}}A:1646-1723 {{PDB3|1y98}}A:1646-1723

{{PDB3|2cou}}A:91-166 {{PDB3|1l7b}}A:589-664 {{PDB3|2cok}}A:385-463

{{PDB3|1wf6}}A:354-431 {{PDB3|1ik9}}C:681-717 {{PDB3|1cdz}}A:538-616

{{PDB3|1oqa}}A:1756-1842 {{PDB3|2coe}}A:27-111

}}

BRCA1 C Terminus (BRCT) domain is a family of evolutionarily related proteins. It is named after the C-terminal domain of BRCA1, a DNA-repair protein that serves as a marker of breast cancer susceptibility.

The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage,{{cite journal |vauthors=Bork P, Hofmann K, Koonin EV, Bucher P, Neuwald AF, Altschul SF |title=A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins |journal=FASEB J. |volume=11 |issue=1 |pages=68–76 |year=1997 |doi=10.1096/fasebj.11.1.9034168 |doi-access=free |pmid=9034168|s2cid=16457619 }} for example as found in the breast cancer DNA-repair protein BRCA1. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain.{{cite journal |doi=10.1126/science.1088753 |vauthors=Yu X, Chini CC, He M, Mer G, Chen J |title=The BRCT domain is a phospho-protein binding domain |journal=Science |volume=302 |issue=5645 |pages=639–642 |year=2003 |pmid=14576433|bibcode=2003Sci...302..639Y |s2cid=29407635 }}