BRD9
Structure and interaction
BRD9 contains a bromodomain. It is closely related to BRD7. BRD9 is present in some SWI/SNF ATPase remodeling complexes.{{Cite journal
| pmid = 23644491
| pmc = 3667980
| year = 2013
| last1 = Kadoch
| first1 = C
| title = Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy
| journal = Nature Genetics
| volume = 45
| issue = 6
| pages = 592–601
| last2 = Hargreaves
| first2 = D. C.
| last3 = Hodges
| first3 = C
| last4 = Elias
| first4 = L
| last5 = Ho
| first5 = L
| last6 = Ranish
| first6 = J
| last7 = Crabtree
| first7 = G. R.
| doi = 10.1038/ng.2628
}}
Role in cancer
The BRD9 gene is frequently present in variable copy number in lung cancer.{{Cite journal
| pmid = 18328944
| year = 2008
| last1 = Kang
| first1 = J. U.
| title = Gain at chromosomal region 5p15.33, containing TERT, is the most frequent genetic event in early stages of non-small cell lung cancer
| journal = Cancer Genetics and Cytogenetics
| volume = 182
| issue = 1
| pages = 1–11
| last2 = Koo
| first2 = S. H.
| last3 = Kwon
| first3 = K. C.
| last4 = Park
| first4 = J. W.
| last5 = Kim
| first5 = J. M.
| doi = 10.1016/j.cancergencyto.2007.12.004
}}
Small molecule inhibition
Small molecules capable of binding to the bromodomain of BRD9 have been developed.{{Cite journal
| pmid = 24313754
| pmc = 3906316
| year = 2014
| last1 = Fedorov
| first1 = O
| title = 1,2,4triazolo4,3-aphthalazines: Inhibitors of diverse bromodomains
| journal = Journal of Medicinal Chemistry
| volume = 57
| issue = 2
| pages = 462–76
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| last14 = Knapp
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| last15 = Brennan
| first15 = P. E.
| doi = 10.1021/jm401568s
| pmid = 25864491
| year = 2015
| last1 = Clark
| first1 = P. G.
| title = LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor
| journal = Angewandte Chemie International Edition
| pages = 6217–6221
| last2 = Vieira
| first2 = L. C.
| last3 = Tallant
| first3 = C
| last4 = Fedorov
| first4 = O
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| first13 = S
| last14 = Brennan
| first14 = P. E.
| last15 = Dixon
| first15 = D. J.
| doi = 10.1002/anie.201501394
| volume=54
| issue = 21
| pmc=4449114
| pmid = 25856009
| year = 2015
| last1 = Theodoulou
| first1 = N. H.
| title = The Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition
| journal = Journal of Medicinal Chemistry
| volume = 59
| issue = 4
| pages = 1425–1439
| last2 = Bamborough
| first2 = P
| last3 = Bannister
| first3 = A. J.
| last4 = Becher
| first4 = I
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| first7 = C. W.
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| first8 = A
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| first10 = D. H.
| last11 = Gordon
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| last12 = Grandi
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| last15 = Michon
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| last21 = Humphreys
| first21 = P. G.
| doi = 10.1021/acs.jmedchem.5b00256
| pmc = 7354103
| doi-access = free
}}