Bartolomeo Gosio
{{Infobox scientist
| name = Bartolomeo Gosio
| native_name =
| native_name_lang =
| image = File:GosioBartolomeo Cannes1920.jpg
| image_size =
| alt =
| caption = Bartolomeo Gosio at the Cannes Medical Conference 1920
| birth_date = {{birth date |1863|03|17|df=y}}
| birth_place = Magliano Alfieri, Piedmont, Italy
| death_date = {{death date and age |1944|04|13|1863|03|17|df=y}}
| death_place = Rome
| death_cause =
| resting_place =
| resting_place_coordinates =
| other_names =
| residence =
| citizenship =
| nationality = Italian
| fields = Medicine
| workplaces = Istituto Superiore di Sanità
Laboratori Scientifici della Direzione di Sanità
| patrons =
| education =
| alma_mater = University of Turin
Sapienza University of Rome
| known_for = Gosio gas (trimethylarsine)
Discovery of mycophenolic acid
}}
Bartolomeo Gosio (17 March 1863 – 13 April 1944) was an Italian medical scientist.{{cite journal|last1=Bentley|first1=R|title=Bartolomeo Gosio, 1863-1944: an appreciation.|journal=Advances in Applied Microbiology|year=2001|volume=48|issue=2001|pages=229–250|doi=10.1016/S0065-2164(01)48005-1|pmid=11677681|isbn=9780120026487}} He discovered a toxic fume, eponymously named "Gosio gas", which is produced by microorganisms, that killed many people. He identified the chemical nature of the gas as an arsenic compound (arsine), but incorrectly named it as diethylarsine.{{cite book|last1=Jones|first1=Roger|title=What's Who?: A Dictionary of Things Named After People and the People They are Named After|year=2008|publisher=Matador|location=Leicester (UK)|isbn=978-1848760-479|page=93|url=https://books.google.com/books?id=46Rx1U5x70QC&q=Bartolomeo+Gosio&pg=PA93|accessdate=23 July 2015}} He also discovered an antibacterial compound called mycophenolic acid from the mould Penicillium brevicompactum. He demonstrated that the novel compound was effective against the deadly anthrax bacterium, Bacillus anthracis. This was the first antibiotic compound isolated in pure and crystallised form. Though the original compound was abandoned in clinical practice due to its adverse effects, its chemical derivative mycophenolate mofetil became the drug of choice as an immunosuppressant in kidney, heart, and liver transplantations.{{cite journal|last1=Allison|first1=A. C.|last2=Kowalski|first2=W. J.|last3=Muller|first3=C. D.|last4=Eugui|first4=E. M.|title=Mechanisms of action of mycophenolic acid|journal=Annals of the New York Academy of Sciences|year=2006|volume=696|issue=1|pages=63–87|doi=10.1111/j.1749-6632.1993.tb17143.x|pmid=7906496|s2cid=34520788}}
Biography
Gosio was born in Magliano Alfieri, Piedmont, Italy. His father Giacomo Gosio, a veterinarian, died just when Bartolomeo completed his elementary education, and he was brought up by his mother Antonietta Troya. He studied medicine at the University of Turin and continued at the Royal University (Sapienza University of Rome). He received his medical degree in 1888. He was appointed at the Laboratory of Bacteriology and Chemistry of the National Hygiene Institute (Istituto Superiore di Sanità) in Rome. Then he went for further training to Max Rubner in Berlin. In 1899 he became director of the Scientific Laboratory of the Public Health Service (Laboratori Scientifici della Direzione di Sanità) in Rome until his death.
Discovery of Gosio gas
In the early 1830s there was an epidemic of sudden infant deaths of unknown cause. Gosio began to investigate the cause. Suspecting the source of the epidemic as coming from the environment, he tested moulds growing inside the houses. At the time wallpapers were most commonly decorated with arsenical colours. He experimentally cultured those moulds on mashed potatoes mixed with arsenic oxide. In 1891 he correctly identified the causative agent as fumes produced by the moulds growing on the wallpapers. He isolated the fumes as mixture of highly volatile compounds, and this mixture was eventually named "Gosio gas" after him. He demonstrated that the fumes easily killed laboratory rats by paralysing their nervous system. A small mouse died within a minute of exposure. He identified several strains of moulds that could produce these toxic fumes. However, he incorrectly identified the main chemical compound as diethylarsine. (It was only in 1921 that the English chemist Frederick Challenger correctly described it as trimethylarsine, an arsine compound which was already synthesised in 1854.{{cite book|last1=Emsley|first1=John|title=The Elements of Murder: A History of Poison|year=2006|publisher=Oxford University Press|location=Oxford|isbn=978-0-19-280600-0|pages=124–126|edition=Paperback.|url=https://books.google.com/books?id=xXVEKN79diAC}})
Discovery of mycophenolic acid
Gosio discovered a novel antibiotic agent in 1893 from a fungus. He collected the fungus from spoiled corn and named it Penicillium glaucum. (But the species was later renamed P. brevicompactum.) In 1896 he could isolate the crystals of the compound, which he successfully demonstrated as the active antibacterial compound against the anthrax bacterium. This was the first antibiotic that was isolated in pure and crystallised form. But the discovery was forgotten.{{cite book|last1=Zhang|first1=Lixin|last2=Demain|first2=Arnold L.|title=Natural Products: Drug Discovery and Therapeutic Medicine|year=2005|publisher=Humana Press|location=Totowa, N.J.|isbn=9781592599769|page=14|url=https://books.google.com/books?id=iP0i7x_38ZwC}} It was rediscovered by two American scientists C.L. Alsberg and O.M. Black in 1912, and gave the name mycophenolic acid.{{cite journal|last1=Silverman Kitchin|first1=Jennifer E.|last2=Pomeranz|first2=Miriam Keltz|last3=Pak|first3=Grace|last4=Washenik|first4=Ken|last5=Shupack|first5=Jerome L.|title=Rediscovering mycophenolic acid: A review of its mechanism, side effects, and potential uses|journal=Journal of the American Academy of Dermatology|year=1997|volume=37|issue=3|pages=445–449|doi=10.1016/S0190-9622(97)70147-6|pmid=9308561|doi-access=free}} The compound was eventually demonstrated to have antiviral, antifungal, antibacterial, anticancer, and antipsoriasis activities.{{cite journal|last1=Regueira|first1=T. B.|last2=Kildegaard|first2=K. R.|last3=Hansen|first3=B. G.|last4=Mortensen|first4=U. H.|last5=Hertweck|first5=C.|last6=Nielsen|first6=J.|title=Molecular Basis for Mycophenolic Acid Biosynthesis in Penicillium brevicompactum|journal=Applied and Environmental Microbiology|year=2011|volume=77|issue=9|pages=3035–3043|doi=10.1128/AEM.03015-10|pmid=21398490|pmc=3126426|bibcode=2011ApEnM..77.3035R }} Although it is not commercialised as antibiotic due to its adverse effects, its modified compound (ester derivative) is an approved immunosuppressant drug in kidney, heart, and liver transplantations, and is marketed under the brands CellCept (mycophenolate mofetil; Roche) and Myfortic (mycophenolate sodium; Novartis).{{cite journal|last1=Bentley|first1=Ronald|title=Mycophenolic Acid: A One Hundred Year Odyssey from Antibiotic to Immunosuppressant|journal=Chemical Reviews|year=2000|volume=100|issue=10|pages=3801–3826|doi=10.1021/cr990097b|pmid=11749328}}
References
{{Commons category|Bartolomeo Gosio (physician)}}
{{Reflist}}
{{Authority control}}
{{DEFAULTSORT:Gosio, Bartolomeo}}
Category:Italian public health doctors
Category:University of Turin alumni
Category:Sapienza University of Rome alumni