Brodie abscess

Brodie's abscess causes a collection of pus in the bone causing pain and swelling.{{cite journal | last1=Chen | first1=Benjamin C | last2=Kobayashi | first2=Takaaki | last3=O'Rourke | first3=Howard | last4=Sekar | first4=Poorani | title=Staphylococcus aureusosteomyelitis causing Brodie's abscess of the tibia in an adult man | journal=BMJ Case Reports | publisher=BMJ | volume=14 | issue=1 | year=2021 | issn=1757-790X | doi=10.1136/bcr-2020-240836 | page=e240836| pmid=33462070 | pmc=7813403 }} There is usually no signs or symptoms of a systematic disease.{{cite journal | last1=Qi | first1=Ruyu | last2=Colmegna | first2=Inés | title=Brodie abscess | journal=Canadian Medical Association Journal | publisher=CMA Joule Inc. | volume=189 | issue=3 | date=2016-09-19 | issn=0820-3946 | doi=10.1503/cmaj.151419 | pages=E117| pmid=27647617 | pmc=5250519 }} Brodie's abscess usually occurs in the tibia or femur.

When it comes to bone infections, there exist multiple etiologies: exposed bone in diabetic wounds, fracture-related bone infection following (open) trauma,{{cite journal | last1=Metsemakers | first1=WJ. | last2=Morgenstern | first2=M. | last3=McNally | first3=M.A. | last4=Moriarty | first4=T.F. | last5=McFadyen | first5=I. | last6=Scarborough | first6=M. | last7=Athanasou | first7=N.A. | last8=Ochsner | first8=P.E. | last9=Kuehl | first9=R. | last10=Raschke | first10=M. | last11=Borens | first11=O. | last12=Xie | first12=Z. | last13=Velkes | first13=S. | last14=Hungerer | first14=S. | last15=Kates | first15=S.L. | last16=Zalavras | first16=C. | last17=Giannoudis | first17=P.V. | last18=Richards | first18=R.G. | last19=Verhofstad | first19=M.H.J. | title=Fracture-related infection: A consensus on definition from an international expert group | journal=Injury | publisher=Elsevier BV | volume=49 | issue=3 | year=2018 | issn=0020-1383 | doi=10.1016/j.injury.2017.08.040 | pages=505–510| pmid=28867644 | hdl=1765/101708 | hdl-access=free }}{{cite journal | last1=Peng | first1=Jiachen | last2=Ren | first2=Youliang | last3=He | first3=Wenbin | last4=Li | first4=Zhengdao | last5=Yang | first5=Jin | last6=Liu | first6=Yi | last7=Zheng | first7=Zhonghui | last8=Kates | first8=Stephen L. | last9=Schwarz | first9=Edward M. | last10=Xie | first10=Chao | last11=Xu | first11=Youjia | title=Epidemiological, Clinical and Microbiological Characteristics of Patients with Post-Traumatic Osteomyelitis of Limb Fractures in Southwest China: A Hospital-Based Study | journal=Journal of Bone and Joint Infection | publisher=Copernicus GmbH | volume=2 | issue=3 | date=2017-05-04 | issn=2206-3552 | doi=10.7150/jbji.20002 | pages=149–153| pmid=28540152 | pmc=5441147 }} or haematogenous osteomyelitis.{{cite journal | last1=Lew | first1=Daniel P | last2=Waldvogel | first2=Francis A | title=Osteomyelitis | journal=The Lancet | publisher=Elsevier BV | volume=364 | issue=9431 | year=2004 | issn=0140-6736 | doi=10.1016/s0140-6736(04)16727-5 | pages=369–379| pmid=15276398 }}{{cite journal | last1=Hotchen | first1=Andrew J. | last2=McNally | first2=Martin A. | last3=Sendi | first3=Parham | title=The Classification of Long Bone Osteomyelitis: A Systemic Review of the Literature | journal=Journal of Bone and Joint Infection | publisher=Copernicus GmbH | volume=2 | issue=4 | date=2017-09-12 | issn=2206-3552 | doi=10.7150/jbji.21050 | pages=167–174| pmid=29119075 | pmc=5671929 }} Causative organisms include Staphylococcus aureus, Pseudomonas, Klebsiella, and coagulase-negative Staphylococcus.

Since patients frequently appear with pain and swelling without a fever, diagnosis can be difficult. Blood cultures and inflammatory indicators are frequently non-revealing, hence a high level of suspicion is required to diagnose this type of osteomyelitis. When diagnosing Brodie's abscess, imaging is crucial. The "target sign" on MRI, which includes central necrosis, surrounding granulation tissue, fibrosis or sclerosis, and an outermost layer of oedema, is distinctive. A biopsy can be useful in ruling out other possible diagnoses, like a bone tumor.

A variety of benign and malignant bone abnormalities, including as cysts, osteoid osteoma, giant cell tumors, chondroblastomas, and Ewing sarcoma, are included in the differential diagnosis of Brodie abscess.

Surgery was the main form of treatment, frequently in conjunction with antibiotics.

The prognosis is usually favorable, with very little likelihood of a lasting disability or recurrence.

Brodie abscess is responsible for 2.5%–42% of primary bone infections.

Brodie abscess is named after Sir Benjamin Collins Brodie, 1st Baronet. In the 1830s, he initially described a chronic inflammatory condition affecting the tibia without obvious acute etiology.{{Cite journal|last1=McHugh|first1=C. H.|last2=Shapeero|first2=L. G.|last3=Folio|first3=L.|last4=Murphey|first4=M. D.|date=July 2007|title=Case for diagnosis. Brodie abscess|journal=Military Medicine|volume=172|issue=7|pages=viii–xi|issn=0026-4075|pmid=17691698}}

• Osteomyelitis
• Osteitis fibrosa cystica

{{Reflist}}

• {{cite journal | last1=Foster | first1=Catherine E. | last2=Taylor | first2=Margaret | last3=Schallert | first3=Erica K. | last4=Rosenfeld | first4=Scott | last5=King | first5=Katherine Y. | title=Brodie Abscess in Children: A 10-Year Single Institution Retrospective Review | journal=Pediatric Infectious Disease Journal | volume=38 | issue=2 | date=2019 | issn=0891-3668 | doi=10.1097/INF.0000000000002062 | pages=e32–e34 | pmid=29620720 | ref=none}}
• {{cite journal | last1=Salik | first1=Muhammad | last2=Mir | first2=Muhammad Hussain | last3=Philip | first3=Deepa | last4=Verma | first4=Shobit | title=Brodie's Abscess: A Diagnostic Conundrum | journal=Cureus | publisher=Springer Science and Business Media LLC | date=2021-07-16 | volume=13 | issue=7 | pages=e16426 | issn=2168-8184 | doi=10.7759/cureus.16426 | doi-access=free | pmid=34422465 | pmc=8369975 | ref=none}}

• [https://gpnotebook.com/pages/uncategorised/brodies-abscess GPnotebook]

{{Medical resources

| ICD11 = {{ICD11|FB84.2}}

| ICD10 = {{ICD10|M86.8}}

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| SNOMED CT = 63375009

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{{Osteochondropathy}}

Category:Bacterial diseases

Category:Osteopathies