CCL14

{{Short description|Mammalian protein found in Homo sapiens}}

{{protein

| Name = chemokine (C-C motif) ligand 14

| caption =

| image =

| width =

| HGNCid = 10612

| Symbol = CCL14

| AltSymbols = SCYA14, HCC-1, HCC-3, NCC-2, SCYL2, CKb1, MCIF

| EntrezGene = 6358

| OMIM = 601392

| RefSeq = NM_032962

| UniProt = Q16627

| PDB =

| ECnumber =

| Chromosome = 17

| Arm = q

| Band = 11.2

| LocusSupplementaryData =

}}

Chemokine (C-C motif) ligand 14 (CCL14) is a small cytokine belonging to the CC chemokine family. It is also commonly known as HCC-1. It is produced as a protein precursor that is processed to generate a mature active protein containing 74 amino acids that and is 46% identical in amino acid composition to CCL3 and CCL4. This chemokine is expressed in various tissues including spleen, bone marrow, liver, muscle, and gut.Schulz-Knappe et al., HCC-1, a novel chemokine from human plasma. J. Exp. Med., 1996, 183: 295-299. CCL14 activates monocytes, but does not induce their chemotaxis. Human CCL14 is located on chromosome 17 within a cluster of other chemokines belonging to the CC family.Naruseet al., A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics, 1996, 34: 236-240.