CFU-Meg

{{short description|Colony forming unit for megakaryocytes in the bone marrow}}

{{Infobox cell

| Name = CFU-Meg

| Latin =

| Image =

| Caption =

| Image2 =

| Caption2 =

| Precursor =

| System =

| Location = Bone marrow

| Function = Colony forming unit

| GivesRiseTo = Megakaryocytes and those to platelets

}}

CFU-Meg is a colony forming unit.

Haematopoiesis in the bone marrow starts off from a haematopoietic stem cell (HSC) and this can differentiate into the myeloid and lymphoid cell lineages. In order to eventually produce a megakaryocyte, the haematopoietic stem cell must generate myeloid cells, so it becomes a common myeloid progenitor, CFU-GEMM. This in turn develops into CFU-Meg, which is the colony forming unit that leads to the production of megakaryocytes.{{cite journal |vauthors=Kimura H, Ohkoshi T, Matsuda S, Uchida T, Kariyone S |title=Megakaryocytopoiesis in polycythemia vera: characterization by megakaryocytic progenitors (CFU-Meg) in vitro and quantitation of marrow megakaryocytes |journal=Acta Haematol. |volume=79 |issue=1 |pages=1–6 |year=1988 |pmid=3124455 |doi= 10.1159/000205681}}{{cite journal |vauthors=Kimura H, Ishibashi T, Sato T, Matsuda S, Uchida T, Kariyone S |title=Megakaryocytic colony formation (CFU-Meg) in essential thrombocythemia: quantitative and qualitative abnormalities of bone marrow CFU-Meg |journal=Am. J. Hematol. |volume=24 |issue=1 |pages=23–30 |date=January 1987 |pmid=3799592 |doi= 10.1002/ajh.2830240104|s2cid=20893511 }}{{cite journal |vauthors=Gallicchio VS, Hughes NK, Hulette BC, Noblitt L |title=Effect of interleukin-1, GM-CSF, erythropoietin, and lithium on the toxicity associated with 3'-azido-3'-deoxythymidine (AZT) in vitro on hematopoietic progenitors (CFU-GM, CFU-MEG, and BFU-E) using murine retrovirus-infected hematopoietic cells |journal=J. Leukoc. Biol. |volume=50 |issue=6 |pages=580–6 |date=December 1991 |doi=10.1002/jlb.50.6.580 |pmid=1940611 |s2cid=9700067 |url=http://www.jleukbio.org/cgi/pmidlookup?view=long&pmid=1940611 |url-access=subscription }}{{Dead link|date=June 2019 |bot=InternetArchiveBot |fix-attempted=yes }}

Some sources prefer the term "CFU-Mega".{{cite book |author=Cotran, Ramzi S. |author2=Kumar, Vinay |author3=Fausto, Nelson |author4=Nelso Fausto |author5=Robbins, Stanley L. |author6=Abbas, Abul K. |title=Robbins and Cotran pathologic basis of disease |publisher=Elsevier Saunders |location=St. Louis, Mo |year=2005 |pages=621 |isbn=0-7216-0187-1 }}