CITED2

{{Short description|Protein-coding gene in humans}}

{{Infobox_gene}}

Cbp/p300-interacting transactivator 2 is a protein that in humans is encoded by the CITED2 gene.{{cite journal | vauthors = Shioda T, Fenner MH, Isselbacher KJ | title = msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 22 | pages = 12298–303 | date = Oct 1996 | pmid = 8901575 | pmc = 37985 | doi = 10.1073/pnas.93.22.12298 | bibcode = 1996PNAS...9312298S | doi-access = free }}{{cite journal | vauthors = Leung MK, Jones T, Michels CL, Livingston DM, Bhattacharya S | title = Molecular cloning and chromosomal localization of the human CITED2 gene encoding p35srj/Mrg1 | journal = Genomics | volume = 61 | issue = 3 | pages = 307–13 | date = Nov 1999 | pmid = 10552932 | doi = 10.1006/geno.1999.5970 }}{{cite web | title = Entrez Gene: CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10370}}

Interactions

CITED2 has been shown to interact with EP300,{{cite journal | vauthors = Bhattacharya S, Michels CL, Leung MK, Arany ZP, Kung AL, Livingston DM | title = Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1 | journal = Genes & Development | volume = 13 | issue = 1 | pages = 64–75 | date = Jan 1999 | pmid = 9887100 | pmc = 316375 | doi = 10.1101/gad.13.1.64 }}{{cite journal | vauthors = Bragança J, Eloranta JJ, Bamforth SD, Ibbitt JC, Hurst HC, Bhattacharya S | title = Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 18 | pages = 16021–9 | date = May 2003 | pmid = 12586840 | doi = 10.1074/jbc.M208144200 | doi-access = free }}{{cite journal | vauthors = Bragança J, Swingler T, Marques FI, Jones T, Eloranta JJ, Hurst HC, Shioda T, Bhattacharya S | title = Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 10 | pages = 8559–65 | date = Mar 2002 | pmid = 11744733 | doi = 10.1074/jbc.M110850200 | doi-access = free }}{{cite journal | vauthors = Glenn DJ, Maurer RA | title = MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression | journal = The Journal of Biological Chemistry | volume = 274 | issue = 51 | pages = 36159–67 | date = Dec 1999 | pmid = 10593900 | doi = 10.1074/jbc.274.51.36159 | doi-access = free }} LHX2, TFAP2A, and WT1.{{cite journal | vauthors = Val P, Martinez-Barbera JP, Swain A | title = Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage | journal = Development | volume = 134 | issue = 12 | pages = 2349–58 | date = Jun 2007 | pmid = 17537799 | doi = 10.1242/dev.004390 | doi-access = free }}

References

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Further reading

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  • {{cite journal | vauthors = Haase M, Schott M, Bornstein SR, Malendowicz LK, Scherbaum WA, Willenberg HS | title = CITED2 is expressed in human adrenocortical cells and regulated by basic fibroblast growth factor | journal = The Journal of Endocrinology | volume = 192 | issue = 2 | pages = 459–65 | date = Feb 2007 | pmid = 17283246 | doi = 10.1677/JOE-06-0083 | doi-access = free }}
  • {{cite journal | vauthors = Shioda T, Fenner MH, Isselbacher KJ | title = MSG1 and its related protein MRG1 share a transcription activating domain | journal = Gene | volume = 204 | issue = 1–2 | pages = 235–41 | date = Dec 1997 | pmid = 9434189 | doi = 10.1016/S0378-1119(97)00551-9 }}
  • {{cite journal | vauthors = Sun HB, Zhu YX, Yin T, Sledge G, Yang YC | title = MRG1, the product of a melanocyte-specific gene related gene, is a cytokine-inducible transcription factor with transformation activity | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 23 | pages = 13555–60 | date = Nov 1998 | pmid = 9811838 | pmc = 24857 | doi = 10.1073/pnas.95.23.13555 | bibcode = 1998PNAS...9513555S | doi-access = free }}
  • {{cite journal | vauthors = Bhattacharya S, Michels CL, Leung MK, Arany ZP, Kung AL, Livingston DM | title = Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1 | journal = Genes & Development | volume = 13 | issue = 1 | pages = 64–75 | date = Jan 1999 | pmid = 9887100 | pmc = 316375 | doi = 10.1101/gad.13.1.64 }}
  • {{cite journal | vauthors = Glenn DJ, Maurer RA | title = MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression | journal = The Journal of Biological Chemistry | volume = 274 | issue = 51 | pages = 36159–67 | date = Dec 1999 | pmid = 10593900 | doi = 10.1074/jbc.274.51.36159 | doi-access = free }}
  • {{cite journal | vauthors = Bragança J, Swingler T, Marques FI, Jones T, Eloranta JJ, Hurst HC, Shioda T, Bhattacharya S | title = Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 10 | pages = 8559–65 | date = Mar 2002 | pmid = 11744733 | doi = 10.1074/jbc.M110850200 | doi-access = free }}
  • {{cite journal | vauthors = Bragança J, Eloranta JJ, Bamforth SD, Ibbitt JC, Hurst HC, Bhattacharya S | title = Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 18 | pages = 16021–9 | date = May 2003 | pmid = 12586840 | doi = 10.1074/jbc.M208144200 | doi-access = free }}
  • {{cite journal | vauthors = Liu L, Amy V, Liu G, McKeehan WL | title = Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells | journal = In Vitro Cellular & Developmental Biology. Animal | volume = 38 | issue = 10 | pages = 582–94 | year = 2003 | pmid = 12762840 | pmc = 3225227 | doi = 10.1290/1543-706X(2002)38<582:NCIMAT>2.0.CO;2 }}
  • {{cite journal | vauthors = Yokota H, Goldring MB, Sun HB | title = CITED2-mediated regulation of MMP-1 and MMP-13 in human chondrocytes under flow shear | journal = The Journal of Biological Chemistry | volume = 278 | issue = 47 | pages = 47275–80 | date = Nov 2003 | pmid = 12960175 | doi = 10.1074/jbc.M304652200 | doi-access = free }}
  • {{cite journal | vauthors = Bhakat KK, Izumi T, Yang SH, Hazra TK, Mitra S | title = Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene | journal = The EMBO Journal | volume = 22 | issue = 23 | pages = 6299–309 | date = Dec 2003 | pmid = 14633989 | pmc = 291836 | doi = 10.1093/emboj/cdg595 }}
  • {{cite journal | vauthors = Tien ES, Davis JW, Vanden Heuvel JP | title = Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator | journal = The Journal of Biological Chemistry | volume = 279 | issue = 23 | pages = 24053–63 | date = Jun 2004 | pmid = 15051727 | doi = 10.1074/jbc.M401489200 | doi-access = free }}
  • {{cite journal | vauthors = Sperling S, Grimm CH, Dunkel I, Mebus S, Sperling HP, Ebner A, Galli R, Lehrach H, Fusch C, Berger F, Hammer S | title = Identification and functional analysis of CITED2 mutations in patients with congenital heart defects | journal = Human Mutation | volume = 26 | issue = 6 | pages = 575–82 | date = Dec 2005 | pmid = 16287139 | doi = 10.1002/humu.20262 | s2cid = 24646760 | hdl = 11858/00-001M-0000-0010-8560-F | hdl-access = free }}
  • {{cite journal | vauthors = Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS | title = Transcriptome analysis of human gastric cancer | journal = Mammalian Genome | volume = 16 | issue = 12 | pages = 942–54 | date = Dec 2005 | pmid = 16341674 | doi = 10.1007/s00335-005-0075-2 | s2cid = 69278 }}
  • {{cite journal | vauthors = Chou YT, Yang YC | title = Post-transcriptional control of Cited2 by transforming growth factor beta. Regulation via Smads and Cited2 coding region | journal = The Journal of Biological Chemistry | volume = 281 | issue = 27 | pages = 18451–62 | date = Jul 2006 | pmid = 16675452 | doi = 10.1074/jbc.M601720200 | doi-access = free }}
  • {{cite journal | vauthors = Qu X, Lam E, Doughman YQ, Chen Y, Chou YT, Lam M, Turakhia M, Dunwoodie SL, Watanabe M, Xu B, Duncan SA, Yang YC | title = Cited2, a coactivator of HNF4alpha, is essential for liver development | journal = The EMBO Journal | volume = 26 | issue = 21 | pages = 4445–56 | date = Oct 2007 | pmid = 17932483 | pmc = 2063472 | doi = 10.1038/sj.emboj.7601883 }}

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