LHX2
{{Short description|Protein-coding gene in the species Homo sapiens}}
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LIM/homeobox protein Lhx2 is a protein that in humans is encoded by the LHX2 gene.{{cite journal |vauthors=Wu HK, Heng HH, Siderovski DP, Dong WF, Okuno Y, Shi XM, Tsui LC, Minden MD | title = Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1 | journal = Oncogene | volume = 12 | issue = 6 | pages = 1205–1212 |date=Jul 1996 | pmid = 8649822 }}{{cite journal |vauthors=Rincon-Limas DE, Lu CH, Canal I, Calleja M, Rodriguez-Esteban C, Izpisua-Belmonte JC, Botas J | title = Conservation of the expression and function of apterous orthologs in Drosophila and mammals | journal = Proc Natl Acad Sci U S A | volume = 96 | issue = 5 | pages = 2165–2170 |date=Apr 1999 | pmid = 10051612 | pmc = 26754 | doi =10.1073/pnas.96.5.2165 | bibcode =1999PNAS...96.2165R | doi-access = free }}{{cite web | title = Entrez Gene: LHX2 LIM homeobox 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9355}}
This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution.
Interactions
LHX2 has been shown to interact with CITED2.{{cite journal |last=Glenn |first=D J |author2=Maurer R A |date=Dec 1999 |title=MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression |journal=J. Biol. Chem. |volume=274 |issue=51 |pages=36159–36167 |location = UNITED STATES| issn = 0021-9258| pmid = 10593900 |doi=10.1074/jbc.274.51.36159 |doi-access=free }}
References
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Further reading
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- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Glenn DJ, Maurer RA |title=MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression |journal=J. Biol. Chem. |volume=274 |issue= 51 |pages= 36159–36167 |year= 2000 |pmid= 10593900 |doi=10.1074/jbc.274.51.36159 |doi-access=free }}
- {{cite journal |vauthors=Bach I, Rodriguez-Esteban C, Carrière C, etal |title=RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex |journal=Nat. Genet. |volume=22 |issue= 4 |pages= 394–399 |year= 1999 |pmid= 10431247 |doi= 10.1038/11970 |s2cid=22326394 }}
- {{cite journal |vauthors=Bendall AJ, Rincón-Limas DE, Botas J, Abate-Shen C |title=Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity |journal=Differentiation |volume=63 |issue= 3 |pages= 151–157 |year= 1998 |pmid= 9697309 |doi=10.1046/j.1432-0436.1998.6330151.x }}
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{{PDB Gallery|geneid=9355}}
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