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CREB5

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Cyclic AMP-responsive element-binding protein 5 is a protein that in humans is encoded by the CREB5 gene.{{cite journal | vauthors = Zu YL, Maekawa T, Nomura N, Nakata T, Ishii S | title = Regulation of trans-activating capacity of CRE-BPa by phorbol ester tumor promoter TPA | journal = Oncogene | volume = 8 | issue = 10 | pages = 2749–58 |date=Oct 1993 | pmid = 8378084 }}{{cite journal | vauthors = Nomura N, Zu YL, Maekawa T, Tabata S, Akiyama T, Ishii S | title = Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1 | journal = J Biol Chem | volume = 268 | issue = 6 | pages = 4259–66 |date=Mar 1993 | doi = 10.1016/S0021-9258(18)53604-8 | pmid = 8440710 | doi-access = free }}{{cite web | title = Entrez Gene: CREB5 cAMP responsive element binding protein 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9586}}

The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1,{{Cite book|url=https://books.google.com/books?id=_MgRdHPKG6sC&q=Cyclic+AMP-responsive+element-binding+protein+5&pg=PA5501|title=Cumulated Index Medicus|date=1993|publisher=U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, National Library of Medicine|language=en}} and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified.

References

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External links

  • {{UCSC gene info|CREB5}}

Further reading

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  • {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
  • {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-style=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }}
  • {{cite journal | author=Hillier LW |title=The DNA sequence of human chromosome 7 |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |name-list-style=vanc| author2=Fulton RS | author3=Fulton LA | display-authors=3 | last4=Graves | first4=Tina A. | last5=Pepin | first5=Kymberlie H. | last6=Wagner-Mcpherson | first6=Caryn | last7=Layman | first7=Dan | last8=Maas | first8=Jason | last9=Jaeger | first9=Sara |bibcode=2003Natur.424..157H | doi-access=free }}
  • {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | author=Harrington JJ |title=Creation of genome-wide protein expression libraries using random activation of gene expression |journal=Nat. Biotechnol. |volume=19 |issue= 5 |pages= 440–5 |year= 2001 |pmid= 11329013 |doi= 10.1038/88107 |name-list-style=vanc| author2=Sherf B | author3=Rundlett S | display-authors=3 | last4=Jackson | first4=P. David | last5=Perry | first5=Rob | last6=Cain | first6=Scott | last7=Leventhal | first7=Christina | last8=Thornton | first8=Mark | last9=Ramachandran | first9=Rakesh |s2cid=25064683 }}
  • {{cite journal |title=Toward a complete human genome sequence |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi= 10.1101/gr.8.11.1097 | author1= |doi-access= free }}

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