Castignano

{{Infobox Italian comune

| name = Castignano

| official_name = Comune di Castignano

| native_name =

| image_skyline = Castignano_vista_1.jpg

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| image_caption = View from Ripaberarda

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| coordinates = {{coord|42|56|20|N|13|37|25|E|type:city(3,039)_region:IT|display=inline,title}}

| coordinates_footnotes =

| region = Marche

| province = Ascoli Piceno (AP)

| frazioni = Ripaberarda, San Venanzo, San Martino, Castiglioni, Rufiano, Sant'Angelo di Ripaberarda

| mayor_party =

| mayor = Fabio Pollini

| area_footnotes =

| area_total_km2 = 38.8

| population_footnotes = All demographics and other statistics: Italian statistical institute Istat.

| population_total = 2755

| population_as_of = 30 June 2017

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| population_demonym = Castignanesi

| elevation_footnotes =

| elevation_m = 473

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| postal_code = 63072

| area_code = 0736

| website = {{official website|http://www.comune.castignano.ap.it/}}

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}}

Castignano is a comune (municipality) in the Province of Ascoli Piceno in the Italian region Marche, located about {{convert|80|km|mi}} south of Ancona and about {{convert|10|km|mi|0}} northeast of Ascoli Piceno.

Castignano borders the following municipalities: Appignano del Tronto, Ascoli Piceno, Cossignano, Montalto delle Marche, Montedinove, Offida, Rotella.

Among its churches are the Sanctuary of San Bernardino da Siena and Santi Pietro e Paolo. Its territory is home to the oldest ever Italic language inscription found, the so-called "Stele of Castignano" (7th-6th centuries BC).