Chondroitin 4-sulfotransferase
{{Short description|Class of enzymes}}
{{infobox enzyme
| Name = chondroitin 4-sulfotransferase
| EC_number = 2.8.2.5
| CAS_number = 83589-04-2
| GO_code = 0047756
| image =
| width =
| caption =
}}
In enzymology, a chondroitin 4-sulfotransferase ({{EC number|2.8.2.5}}) is an enzyme that catalyzes the chemical reaction
:3'-phosphoadenosine-5'-phosphosulfate + chondroitin adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and chondroitin, whereas its two products are adenosine 3',5'-bisphosphate and chondroitin 4'-sulfate.
This enzyme belongs to the family of transferases, to be specific, the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:chondroitin 4'-sulfotransferase. This enzyme is also called chondroitin sulfotransferase. This enzyme participates in 3 metabolic pathways: chondroitin sulfate biosynthesis, sulfur metabolism, and the biosynthesis of glycan structures.
References
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- {{cite journal | vauthors = Habuchi O, Miyashita N | year = 1982 | title = Separation and characterization of chondroitin 6-sulfotransferase and chondroitin 4-sulfotransferase from chick embryo cartilage | journal = Biochim. Biophys. Acta | volume = 717 | pages = 414–21 | pmid = 6957247 | issue = 3 | doi=10.1016/0304-4165(82)90282-3}}
- {{cite journal | vauthors = Nakanishi Y, Otsu K, Suzuki S | year = 1983 | title = Enzymatic transfer of galactosyl phosphate from UDP-galactose to UDP-N-acetylglucosamine | journal = FEBS Lett. | volume = 151 | pages = 15–8 | pmid = 6130977 | doi = 10.1016/0014-5793(83)80332-9 | issue = 1 | doi-access = free }}
- {{cite journal | vauthors = Nakanishi Y, Shimizu M, Otsu K, Kato S, Tsuji M, Suzuki S | year = 1981 | title = A terminal 6-sulfotransferase catalyzing a synthesis of N-acetylgalactosamine 4,6-bissulfate residue at the nonreducing terminal position of chondroitin sulfate | journal = J. Biol. Chem. | volume = 256 | pages = 5443–9 | pmid = 6787041 | issue = 11 }}
- {{cite journal |author1 = Suzuki S |author2 =Strominger JL | year = 1960 | title = Enzymatic sulfation of mucopolysaccharides in hen oviduct. I Transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to mucopolysaccharides | journal = J. Biol. Chem. | volume = 235 | pages = 257–266 | pmid=13835879}}
- {{cite journal |author1 = Suzuki S |author2 =Strominger JL | year = 1960 | title = Enzymatic sulfation of mucopolysaccharides in hen oviduct. II Mechanism of the reaction studied with oligosaccharides and monosaccharides as acceptors | journal = J. Biol. Chem. | volume = 235 | pages = 267–273 | pmid=13835880}}
- {{cite journal |author1 = Suzuki S |author2 =Strominger JL | year = 1960 | title = Enzymatic sulfation of mucopolysaccharides in hen oviduct. III Mechanism of sulfation of chondroitin and chondroitin sulfate A | journal = J. Biol. Chem. | volume = 235 | pages = 274–276 | pmid=13835881}}
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{{Sulfur-containing group transferases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}
Category:Enzymes of unknown structure
{{2.8-enzyme-stub}}