Christine Orengo
{{short description|Professor of Bioinformatics}}
{{Use dmy dates|date=March 2018}}
{{Use British English|date=March 2018}}
{{Infobox scientist
| name = Christine Orengo
| honorific_suffix ={{post-nominals|country=GBR|FRS|size=100%}}
| birth_name = Christine Anne Orengo
| image = ISMB18_031_(43419102575).jpg
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| caption = Christine Orengo in speaking at the Intelligent Systems for Molecular Biology (ISMB) conference in Chicago in 2018
| birth_date = {{Birth date and age|1955|6|22|df=y}}{{LCAuth|n2013022814|Christine Orengo||}}
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| other_names =
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| fields = {{Plainlist|
- Protein structure
- Protein structure comparison
- Protein structure prediction
- Protein function prediction
- Bioinformatics}}
| workplaces = {{Plainlist|
- National Institute for Medical Research (NIMR)
- University College London (UCL)}}
| patrons =
| alma_mater = {{Plainlist|
- University of Bristol (BSc)
- University of Aberdeen (MSc)
- University College London (PhD)}}
| thesis_title = A study of the redox properties of haem in proteins and model systems
| thesis_url = https://catalogue.libraries.london.ac.uk/record=b1528840
| thesis_year = 1984
| doctoral_advisor =
| academic_advisors =
| doctoral_students = Camilla Pang
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| known_for = {{Plainlist|
- CATH database{{Cite journal | last1 = Orengo | first1 = C. A. | last2 = Michie | first2 = A. D. | last3 = Jones | first3 = S. | last4 = Jones | first4 = D. T. | last5 = Swindells | first5 = M. B. | last6 = Thornton | first6 = J. M. | author-link6 = Janet Thornton| doi = 10.1016/S0969-2126(97)00260-8 | title = CATH – a hierarchic classification of protein domain structures | journal = Structure | volume = 5 | issue = 8 | pages = 1093–1109 | year = 1997 | pmid = 9309224| doi-access = free }}}}
| influences =
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| awards = EMBO Membership (2014){{cite web|url=http://www.embo.org/documents/members/The_EMBO_Pocket_Directory.pdf|title=The EMBO Pocket Directory|archive-url=https://web.archive.org/web/20150316002020/http://www.embo.org/documents/members/The_EMBO_Pocket_Directory.pdf|archive-date=2015-03-16|author=Anon|year=2015|publisher=European Molecular Biology Organization|location=Heidelberg}}
| website = {{Official URL}}
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}}Christine Anne Orengo {{post-nominals|country=GBR|FRS}} is a Professor of Bioinformatics at University College London (UCL){{Google Scholar id}}{{Scopus id}}{{EuropePMC|ORCID=0000-0002-7141-8936}}Christine Orengo's {{ORCID|0000-0002-7141-8936}} known for her work on protein structure, particularly the CATH database.{{cite web|archive-url=https://web.archive.org/web/20150519235608/http://www.ucl.ac.uk/orengo-group/lab-members/christine-orengo|archive-date=2015-05-19|url=http://www.ucl.ac.uk/orengo-group/lab-members/christine-orengo|title=Professor Christine Orengo|publisher=University College London}} Orengo serves as president of the International Society for Computational Biology (ISCB), the first woman to do so in the history of the society.{{cite web|url=https://www.iscb.org/cms_addon/leadership/index.php |title=Officers and Directors |publisher=Iscb.org |access-date=2020-02-29}}
Education
Orengo studied Chemical Physics at the University of Bristol where she was awarded a Bachelor of Science degree in 1976.{{cite web |title=GeCIP Detailed Research Plan Form |url=https://www.genomicsengland.co.uk/wp-content/uploads/2018/02/Functional-Effects-detailed-research-plan.pdf |website=Genomics England |access-date=27 April 2021}} She continued her studies at the University of Aberdeen where she was awarded a Master of Science degree in Medical Physics in 1977 for research on the disruption of iron metabolism in laboratory rats with Yoshida sarcomas.{{cite thesis |degree=MSc |first=Christine Anne|last=Orengo |title=Disruption of iron metabolism in rats with Yoshida sarcomas |publisher=University of Aberdeen |date=1977 |oclc=646442339}} She was awarded a PhD for research on the redox properties of haem in proteins in 1984 from UCL.{{cite thesis |degree=PhD |first=Christine Anne|last=Orengo |title=A study of the redox properties of haem in proteins and model systems |publisher=University College London |date=1984 |website=london.ac.uk|url=https://catalogue.libraries.london.ac.uk/record=b1528840|oclc=927065626}}
Career and research
Following her PhD, Orengo worked in industry as Chief Chemist for FCI International, Brussels and mathematical modeller for Humphreys & Glasgow in London. In 1987 she was appointed a postdoctoral researcher at the National Institute for Medical Research (NIMR) in Mill Hill where she worked until 1990. She joined the department of biochemistry and molecular biology at UCL and in 1995 and was awarded a Medical Research Council (MRC) senior fellowship in Bioinformatics. She was promoted to Professor of Bioinformatics in 2002.
Orengo's research analyses genes, proteins and biological systems using computational methods to classify proteins into evolutionary families. Her research has been funded by the Medical Research Council and the Biotechnology and Biological Sciences Research Council (BBSRC).{{cite web|archive-url=https://web.archive.org/web/20151127152559/http://gtr.rcuk.ac.uk/person/F46ADFDD-DAA2-4094-ADC5-1D3676E95F0E|url=http://gtr.rcuk.ac.uk/person/F46ADFDD-DAA2-4094-ADC5-1D3676E95F0E|date=2015-11-27|publisher=Research Councils UK|title=UK Government research grants awarded to Christine Orengo|archive-date=2015-11-27}}
Orengo is co-editor with David Jones and Janet Thornton of the textbook Bioinformatics: Genes, Proteins and Computers.{{cite book |year=2003 |title=Bioinformatics: Genes, Proteins and Computers |publisher=BIOS |isbn=1859960545}} {{As of|2021}}, according to Google Scholar and Scopus her most cited work has been published in Nature,{{cite journal|last1=Orengo|first1=Christine Anne|last2=Jones|first2=David T.|last3=Thornton|first3=Janet M.|title=Protein superfamilles and domain superfolds|journal=Nature|volume=372|issue=6507|year=1994|pages=631–634|issn=0028-0836|doi=10.1038/372631a0|pmid=7990952|bibcode=1994Natur.372..631O|s2cid=4330359}} Nucleic Acids Research,{{Cite journal| last1 = Hunter | first1 = S.| last2 = Apweiler | first2 = R. | author-link2 = Rolf Apweiler | first3 = T. | last3 = Attwood | author-link3 = Terri Attwood| last4 = Bairoch | first4 = A. | author-link4 = Amos Bairoch| first5 = A. | last5 = Bateman | author-link5 = Alex Bateman| first6 = D.| last6 = Binns | first7 = P.| last7 = Bork | author-link7 = Peer Bork| first8 = U. | last8 = Das| last9 = Daugherty | first9 = L.| last10 = Duquenne | first10 = L.| last11 = Finn | first11 = R. D.| last12 = Gough | first12 = J. | author-link12 = Julian Gough (scientist)| last13 = Haft | first13 = D.| last14 = Hulo | first14 = N.| last15 = Kahn | first15 = D.| last16 = Kelly | first16 = E.| last17 = Laugraud | first17 = A.| last18 = Letunic | first18 = I.| last19 = Lonsdale | first19 = D.| last20 = Lopez | first20 = R.| last21 = Madera | first21 = M.| last22 = Maslen | first22 = J.| last23 = McAnulla | first23 = C.| last24 = McDowall | first24 = J.| last25 = Mistry | first25 = J.| last26 = Mitchell | first26 = A.| last27 = Mulder | first27 = N.| last28 = Natale | first28 = D.| last29 = Orengo | first29 = C.| last30 = Quinn | first30 = A. F.| title = InterPro: the integrative protein signature database| journal = Nucleic Acids Research| volume = 37| issue = Database issue| pages = D211–D215| date=Jan 2009 | issn = 0305-1048| pmid = 18940856| pmc = 2686546| doi = 10.1093/nar/gkn785
}} Structure and the Journal of Molecular Biology.{{cite journal|last1=Todd|first1=Annabel E|last2=Orengo|first2=Christine A|last3=Thornton|first3=Janet M|s2cid=14355820|pmid=11286560|title=Evolution of function in protein superfamilies, from a structural perspective|journal=Journal of Molecular Biology|volume=307|issue=4|year=2001|pages=1113–1143|issn=0022-2836|doi=10.1006/jmbi.2001.4513|doi-access=free}}{{cite journal|last1=Taylor|first1=William R.|last2=Orengo|first2=Christine Anne|title=Protein structure alignment|journal=Journal of Molecular Biology|volume=208|issue=1|year=1989|pages=1–22|issn=0022-2836|doi=10.1016/0022-2836(89)90084-3|pmid= 2769748}} Her former doctoral students include Camilla Pang,{{cite thesis|degree=PhD|publisher=University College London|url=https://discovery.ucl.ac.uk/id/eprint/10047500/|oclc=1063745930|title=Developing a computational approach to investigate the impacts of disease-causing mutations on protein function|first= Camilla Sih Mai|last=Pang|date=2018|id={{EThOS|uk.bl.ethos.747644}}|website=ucl.ac.uk}} {{free access}} Sonja Lehtinen{{cite journal|last1=Lehtinen|first1=Sonja|last2=Bähler|first2=Jürg|last3=Orengo|first3=Christine|title=Co-Expression Network Models Suggest that Stress Increases Tolerance to Mutations|journal=Scientific Reports|volume=5|year=2015|page=16726|issn=2045-2322|doi=10.1038/srep16726|pmid=26568486|pmc=4644955|bibcode=2015NatSR...516726L}} {{open access}}{{cite web|url=http://www.ucl.ac.uk/orengo-group/lab-members/previous_lab_members|archive-url=https://web.archive.org/web/20150522182402/http://www.ucl.ac.uk/orengo-group/lab-members/previous_lab_members|date=2015-05-22|publisher=University College London|title=Orengo lab alumni|archive-date=2015-05-22}} and Ian Sillitoe.{{cite thesis|degree=PhD|publisher=University College London|title=Consensus templates for protein structure recognition|first= Ian|last=Sillitoe|date=2003|id={{EThOS|404942}}|oclc=500146824|website=london.ac.uk|url=https://catalogue.libraries.london.ac.uk/record=b2037236}}
=Awards and honours=
Orengo was elected a member of the European Molecular Biology Organization (EMBO) in 2014 and a Fellow of the Royal Society (FRS) in 2019.{{cite web|archive-url=https://web.archive.org/web/20151206230514/http://people.embo.org/profile/christine-a-orengo|archive-date=2015-12-06|url=http://people.embo.org/profile/christine-a-orengo|title=EMBO member: Christine Anne Orengo|publisher=EMBO|location=Heidelberg}}{{cite web|url=https://royalsociety.org/people/christine-orengo-14112/|website=royalsociety.org|archive-url=https://web.archive.org/web/20190424061408/https://royalsociety.org/people/christine-orengo-14112/|archive-date=2019-04-24|location=London|title=Professor Christine Orengo FRS|author=Anon|year=2019}} One or more of the preceding sentences incorporates text from the royalsociety.org website where: {{quote|“All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --{{Webarchive|url=https://web.archive.org/web/20161111170346/https://royalsociety.org/about-us/terms-conditions-policies/|title=Royal Society Terms, conditions and policies|date=2016-11-11}}}}
References
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{{ISCB Fellows}}
{{FRS 2019}}
{{Authority control}}
{{DEFAULTSORT:Orengo, Christine}}
Category:British bioinformaticians
Category:Place of birth missing (living people)
Category:Alumni of the University of Bristol
Category:Alumni of the University of Aberdeen
Category:Alumni of University College London
Category:Members of the European Molecular Biology Organization
Category:Fellows of the International Society for Computational Biology