Condylostoma nuclear code

{{Short description|An alternative genetic code found in the nuclear genome of some ciliates}}

{{DISPLAYTITLE:Condylostoma nuclear code}}

The Condylostoma nuclear code (translation table 28) is a genetic code used by the nuclear genome of the heterotrich ciliate Condylostoma magnum.{{Cite journal|last=Heaphy|first=Stephen M.|last2=Mariotti|first2=Marco|last3=Gladyshev|first3=Vadim N.|last4=Atkins|first4=John F.|last5=Baranov|first5=Pavel V.|date=2016-11-01|title=Novel Ciliate Genetic Code Variants Including the Reassignment of All Three Stop Codons to Sense Codons in Condylostoma magnum|journal=Molecular Biology and Evolution|language=en|volume=33|issue=11|pages=2885–2889|doi=10.1093/molbev/msw166|issn=0737-4038|pmc=5062323|pmid=27501944}} This code, along with translation tables 27 and 31, is remarkable in that every one of the 64 possible codons can be a sense codon. Experimental evidence suggests that translation termination relies on context, specifically proximity to the poly(A) tail. Near such a tail, PABP could help terminate the protein by recruiting eRF1 and eRF3 to prevent the cognate tRNA from binding.{{Cite journal|last=Swart|first=Estienne Carl|last2=Serra|first2=Valentina|last3=Petroni|first3=Giulio|last4=Nowacki|first4=Mariusz|title=Genetic Codes with No Dedicated Stop Codon: Context-Dependent Translation Termination|journal=Cell|volume=166|issue=3|pages=691–702|doi=10.1016/j.cell.2016.06.020|pmc=4967479|pmid=27426948|year=2016}}