Cripavirus

{{Virusbox

| taxon = Cripavirus

}}

Cripavirus is a genus of viruses in the order Picornavirales, in the family Dicistroviridae. Invertebrates serve as natural hosts. There are five species in this genus. Diseases associated with this genus include: DCV: increased reproductive potential; extremely pathogenic when injected with high associated mortality; CrPV: paralysis and death.{{cite web|title=Viral Zone|url=http://viralzone.expasy.org/all_by_species/301.html|publisher=ExPASy|access-date=15 June 2015}}{{cite web|title=Virus Taxonomy: 2024 Release|url=https://ictv.global/taxonomy|publisher=International Committee on Taxonomy of Viruses|access-date=20 March 2025}} These viruses can produce proteins directly from their RNA genome upon entering a cell; and therefore, does not require an RNA polymerase packaged in with it, as this may be produced from the genome after entering the cell.[http://phene.cpmc.columbia.edu/ICTVdB/00.101.0.01.htm International Committee on the Taxonomy of Viruses] {{webarchive|url=https://web.archive.org/web/20081201220817/http://phene.cpmc.columbia.edu/ICTVdB/00.101.0.01.htm |date=1 December 2008 }}

The name of the Cripavirus genus originates from its most famous member the Cricket Paralysis Virus. Which was made famous by its rather unusual IRES (Internal Ribosome Entry Site): the Cripavirus IRES. The Cripavirus IRES is an RNA element that allows the virus to bind the ribosome and translate without a need for any initiation factors{{citation

|title=Structure and Function of Regulatory RNA Elements

|journal=Biochimica et Biophysica Acta

|volume=1789

|year=2009

|pages=542–557

|pmid=19632368

|doi=10.1016/j.bbagrm.2009.07.005

|last1=Balvay

|first1=L.

|last2=Soto Rifo

|first2=R.

|last3=Ricci

|first3=E. P.

|last4=Decimo

|first4=D.

|last5=Ohlmann

|first5=T.

|issue=9–10

}} – as initiation is the most regulated step of translation this allows the virus to avoid many mechanisms to inhibit viral activity.

Taxonomy

The genus contains the following species, listed by scientific name and followed by the exemplar virus of the species:

Cripavirus drosophilae, Drosophila C virus
Cripavirus grylli, Cricket paralysis virus
Cripavirus mortiferum, Aphid lethal paralysis virus
Cripavirus porteri, Solenopsis invicta virus 6
Cripavirus ropadi, Rhopalosiphum padi virus

Structure

File:OPSR.Dic.Fig2.Dicistroviridae.v4.png

Viruses in Cripavirus are non-enveloped, have capsids of 12 capsomers, and have icosahedral geometries with T=pseudo3 symmetry. The diameter is around 30 nm. Genomes are linear and non-segmented, around 8.5–10.2kb in length, and has a VPg (genome linked viral protein) on the 5' end. The 5' end also has a series of C's near it, while the 3' end has a series of A's near it. The genome has 2 open reading frames.

Genus	Structure \|\| Symmetry	Capsid	Genomic arrangement	Genomic segmentation
class="wikitable sortable" style="text-align:center"
Cripavirus	Icosahedral	Pseudo T=3	Non-enveloped	Linear	Monopartite

Life cycle

Entry into the host cell is achieved by penetration into the host cell. Replication follows the positive stranded RNA virus replication model. Positive stranded rna virus transcription is the method of transcription. Translation takes place by viral initiation, and ribosomal skipping. Invertebrates serve as the natural host. Transmission routes are contamination.

Genus	Host details	Tissue tropism	Entry details	Release details	Replication site	Assembly site	Transmission
class="wikitable sortable" style="text-align:center"
Cripavirus	Invertebrates	None	Cell receptor endocytosis	Budding	Cytoplasm	Cytoplasm	Food

References

External links

[http://viralzone.expasy.org/all_by_species/301.html Viralzone: Cripavirus]
[http://ictvonline.org/virusTaxonomy.asp ICTV]

Category:Dicistroviridae

Category:Virus genera