DBN1

{{Short description|Protein-coding gene in the species Homo sapiens}}

Drebrin is a protein that in humans is encoded by the DBN1 gene.{{cite journal | vauthors = Toda M, Shirao T, Minoshima S, Shimizu N, Toya S, Uyemura K | title = Molecular cloning of cDNA encoding human drebrin E and chromosomal mapping of its gene | journal = Biochem Biophys Res Commun | volume = 196 | issue = 1 | pages = 468–72 |date=Nov 1993 | pmid = 8216329 | doi = 10.1006/bbrc.1993.2273 }}{{cite web | title = Entrez Gene: DBN1 drebrin 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1627}}

The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene.

References

{{cite journal | author=Shirao T |title=The roles of microfilament-associated proteins, drebrins, in brain morphogenesis: a review |journal=J. Biochem. |volume=117 |issue= 2 |pages= 231–6 |year= 1995 |pmid= 7608104 |doi=10.1093/jb/117.2.231 |doi-access=free }}
{{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
{{cite journal | vauthors=Harigaya Y, Shoji M, Shirao T, Hirai S |title=Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease |journal=J. Neurosci. Res. |volume=43 |issue= 1 |pages= 87–92 |year= 1996 |pmid= 8838578 |doi= 10.1002/jnr.490430111 |s2cid=40336358 }}
{{cite journal | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
{{cite journal | vauthors=Mammoto A, Sasaki T, Asakura T |title=Interactions of drebrin and gephyrin with profilin |journal=Biochem. Biophys. Res. Commun. |volume=243 |issue= 1 |pages= 86–9 |year= 1998 |pmid= 9473484 |doi= 10.1006/bbrc.1997.8068 |display-authors=etal}}
{{cite journal | vauthors=Hayashi K, Ishikawa R, Kawai-Hirai R |title=Domain analysis of the actin-binding and actin-remodeling activities of drebrin |journal=Exp. Cell Res. |volume=253 |issue= 2 |pages= 673–80 |year= 2000 |pmid= 10585290 |doi= 10.1006/excr.1999.4663 |display-authors=etal}}
{{cite journal | vauthors=Peitsch WK, Grund C, Kuhn C |title=Drebrin is a widespread actin-associating protein enriched at junctional plaques, defining a specific microfilament anchorage system in polar epithelial cells |journal=Eur. J. Cell Biol. |volume=78 |issue= 11 |pages= 767–78 |year= 2000 |pmid= 10604653 |doi= 10.1016/s0171-9335(99)80027-2|display-authors=etal}}
{{cite journal | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }}
{{cite journal | vauthors=Wiemann S, Weil B, Wellenreuther R |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 |display-authors=etal}}
{{cite journal | vauthors=Simpson JC, Wellenreuther R, Poustka A |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732 |display-authors=etal}}
{{cite journal | vauthors=Kobayashi S, Shirao T, Sasaki T |title=Drebrin expression is increased in spinal motoneurons of rats after axotomy |journal=Neurosci. Lett. |volume=311 |issue= 3 |pages= 165–8 |year= 2001 |pmid= 11578820 |doi=10.1016/S0304-3940(01)02155-3 |s2cid=15935730 }}
{{cite journal | vauthors=Shim KS, Lubec G |title=Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome |journal=Neurosci. Lett. |volume=324 |issue= 3 |pages= 209–12 |year= 2002 |pmid= 12009525 |doi=10.1016/S0304-3940(02)00210-0 |s2cid=20834151 }}
{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
{{cite journal | vauthors=Gevaert K, Goethals M, Martens L |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 |s2cid=23783563 |display-authors=etal}}
{{cite journal | vauthors=Shiraishi Y, Mizutani A, Mikoshiba K, Furuichi T |title=Coincidence in dendritic clustering and synaptic targeting of homer proteins and NMDA receptor complex proteins NR2B and PSD95 during development of cultured hippocampal neurons |journal=Mol. Cell. Neurosci. |volume=22 |issue= 2 |pages= 188–201 |year= 2003 |pmid= 12676529 |doi=10.1016/S1044-7431(03)00037-X |s2cid=38323844 }}
{{cite journal | vauthors=Peitsch WK, Hofmann I, Endlich N |title=Cell biological and biochemical characterization of drebrin complexes in mesangial cells and podocytes of renal glomeruli |journal=J. Am. Soc. Nephrol. |volume=14 |issue= 6 |pages= 1452–63 |year= 2003 |pmid= 12761245 |doi=10.1097/01.ASN.0000069222.63700.DE |display-authors=etal|doi-access=free }}
{{cite journal | vauthors=Salazar MA, Kwiatkowski AV, Pellegrini L |title=Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton |journal=J. Biol. Chem. |volume=278 |issue= 49 |pages= 49031–43 |year= 2004 |pmid= 14506234 |doi= 10.1074/jbc.M308104200 |display-authors=etal|doi-access=free }}
{{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}

DBN1

References

Further reading