DOC2A
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Double C2-like domain-containing protein alpha is a protein that in humans is encoded by the DOC2A gene.{{cite journal | vauthors = Orita S, Sasaki T, Naito A, Komuro R, Ohtsuka T, Maeda M, Suzuki H, Igarashi H, Takai Y | title = Doc2: a novel brain protein having two repeated C2-like domains | journal = Biochem Biophys Res Commun | volume = 206 | issue = 2 | pages = 439–48 |date=Feb 1995 | pmid = 7826360 | doi = 10.1006/bbrc.1995.1062 }}{{cite journal | vauthors = Mochida S, Orita S, Sakaguchi G, Sasaki T, Takai Y | title = Role of the Doc2α–Munc13–1 interaction in the neurotransmitter release process | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 19 | pages = 11418–22 |date=Oct 1998 | pmid = 9736751 | pmc = 21657 | doi =10.1073/pnas.95.19.11418 | bibcode = 1998PNAS...9511418M | doi-access = free }}{{cite web | title = Entrez Gene: DOC2A double C2-like domains, alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8448}}
There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release.
Interactions
DOC2A has been shown to interact with UNC13B{{cite journal | vauthors = Orita S, Naito A, Sakaguchi G, Maeda M, Igarashi H, Sasaki T, Takai Y | title = Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery | journal = J. Biol. Chem. | volume = 272 | issue = 26 | pages = 16081–4 |date=June 1997 | pmid = 9195900 | doi = 10.1074/jbc.272.26.16081 | doi-access = free }} and UNC13A.{{cite web|title=Protein unc-13 homolog A|url=https://www.uniprot.org/uniprot/Q9UPW8|website=UniProt}}
References
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Further reading
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- {{cite journal | vauthors = Sakaguchi G, Orita S, Maeda M, Igarashi H, Takai Y | title = Molecular cloning of an isoform of Doc2 having two C2-like domains | journal = Biochem. Biophys. Res. Commun. | volume = 217 | issue = 3 | pages = 1053–61 |date=December 1995 | pmid = 8554557 | doi = 10.1006/bbrc.1995.2876}}
- {{cite journal | vauthors = Verhage M, de Vries KJ, Røshol H, Burbach JP, Gispen WH, Südhof TC | title = DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion | journal = Neuron | volume = 18 | issue = 3 | pages = 453–61 |date=March 1997 | pmid = 9115738 | doi = 10.1016/S0896-6273(00)81245-3 | s2cid = 17948539 | doi-access = free }}
- {{cite journal | vauthors = Nagano F, Orita S, Sasaki T, Naito A, Sakaguchi G, Maeda M, Watanabe T, Kominami E, Uchiyama Y, Takai Y | title = Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport | journal = J. Biol. Chem. | volume = 273 | issue = 46 | pages = 30065–8 |date=November 1998 | pmid = 9804756 | doi = 10.1074/jbc.273.46.30065 | doi-access = free }}
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