UNC13B

This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.

UNC13B has been shown to interact with:

• DOC2A,{{cite journal | vauthors = Orita S, Naito A, Sakaguchi G, Maeda M, Igarashi H, Sasaki T, Takai Y | title = Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery | journal = J. Biol. Chem. | volume = 272 | issue = 26 | pages = 16081–4 | date = June 1997 | pmid = 9195900 | doi = 10.1074/jbc.272.26.16081| doi-access = free }}{{cite journal | vauthors = Mochida S, Orita S, Sakaguchi G, Sasaki T, Takai Y | title = Role of the Doc2 alpha-Munc13-1 interaction in the neurotransmitter release process | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 19 | pages = 11418–22 | date = September 1998 | pmid = 9736751 | pmc = 21657 | doi = 10.1073/pnas.95.19.11418| bibcode = 1998PNAS...9511418M | doi-access = free }}
• RIMS1,{{cite journal | vauthors = Betz A, Thakur P, Junge HJ, Ashery U, Rhee JS, Scheuss V, Rosenmund C, Rettig J, Brose N | title = Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming | journal = Neuron | volume = 30 | issue = 1 | pages = 183–96 | date = April 2001 | pmid = 11343654 | doi = 10.1016/s0896-6273(01)00272-0| hdl = 11858/00-001M-0000-0012-F596-C | s2cid = 155875 | hdl-access = free }}{{cite journal | vauthors = Ohtsuka T, Takao-Rikitsu E, Inoue E, Inoue M, Takeuchi M, Matsubara K, Deguchi-Tawarada M, Satoh K, Morimoto K, Nakanishi H, Takai Y | title = Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1 | journal = J. Cell Biol. | volume = 158 | issue = 3 | pages = 577–90 | date = August 2002 | pmid = 12163476 | pmc = 2173811 | doi = 10.1083/jcb.200202083 }}
• SPTBN2,{{cite journal | vauthors = Sakaguchi G, Orita S, Naito A, Maeda M, Igarashi H, Sasaki T, Takai Y | title = A novel brain-specific isoform of beta spectrin: isolation and its interaction with Munc13 | journal = Biochem. Biophys. Res. Commun. | volume = 248 | issue = 3 | pages = 846–51 | date = July 1998 | pmid = 9704016 | doi = 10.1006/bbrc.1998.9067 }}
• STX1A, and
• STX1B.{{cite journal | vauthors = Betz A, Okamoto M, Benseler F, Brose N | title = Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin | journal = J. Biol. Chem. | volume = 272 | issue = 4 | pages = 2520–6 | date = January 1997 | pmid = 8999968 | doi = 10.1074/jbc.272.4.2520| doi-access = free }}

{{Clear}}

{{Reflist|35em}}

{{Refbegin|35em}}

• {{cite journal | vauthors = Betz A, Okamoto M, Benseler F, Brose N | title = Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin | journal = J. Biol. Chem. | volume = 272 | issue = 4 | pages = 2520–6 | year = 1997 | pmid = 8999968 | doi = 10.1074/jbc.272.4.2520 | doi-access = free }}
• {{cite journal | vauthors = Orita S, Naito A, Sakaguchi G, Maeda M, Igarashi H, Sasaki T, Takai Y | title = Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery | journal = J. Biol. Chem. | volume = 272 | issue = 26 | pages = 16081–4 | year = 1997 | pmid = 9195900 | doi = 10.1074/jbc.272.26.16081 | doi-access = free }}
• {{cite journal | vauthors = Sakaguchi G, Orita S, Naito A, Maeda M, Igarashi H, Sasaki T, Takai Y | title = A novel brain-specific isoform of beta spectrin: isolation and its interaction with Munc13 | journal = Biochem. Biophys. Res. Commun. | volume = 248 | issue = 3 | pages = 846–51 | year = 1998 | pmid = 9704016 | doi = 10.1006/bbrc.1998.9067 }}
• {{cite journal | vauthors = Mochida S, Orita S, Sakaguchi G, Sasaki T, Takai Y | title = Role of the Doc2α–Munc13–1 interaction in the neurotransmitter release process | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 19 | pages = 11418–22 | year = 1998 | pmid = 9736751 | pmc = 21657 | doi = 10.1073/pnas.95.19.11418 | bibcode = 1998PNAS...9511418M | doi-access = free }}
• {{cite journal | vauthors = Song Y, Ailenberg M, Silverman M | title = Human munc13 Is a Diacylglycerol Receptor that Induces Apoptosis and May Contribute to Renal Cell Injury in Hyperglycemia | journal = Mol. Biol. Cell | volume = 10 | issue = 5 | pages = 1609–19 | year = 1999 | pmid = 10233166 | pmc = 30485 | doi = 10.1091/mbc.10.5.1609 }}
• {{cite journal | vauthors = Duncan RR, Betz A, Shipston MJ, Brose N, Chow RH | title = Transient, phorbol ester-induced DOC2-Munc13 interactions in vivo | journal = J. Biol. Chem. | volume = 274 | issue = 39 | pages = 27347–50 | year = 1999 | pmid = 10488064 | doi = 10.1074/jbc.274.39.27347 | doi-access =free }}
• {{cite journal | vauthors = Betz A, Thakur P, Junge HJ, Ashery U, Rhee JS, Scheuss V, Rosenmund C, Rettig J, Brose N | title = Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming | journal = Neuron | volume = 30 | issue = 1 | pages = 183–96 | year = 2001 | pmid = 11343654 | doi = 10.1016/S0896-6273(01)00272-0 | hdl = 11858/00-001M-0000-0012-F596-C | s2cid = 155875 | hdl-access = free }}
• {{cite journal | vauthors = Schoch S, Castillo PE, Jo T, Mukherjee K, Geppert M, Wang Y, Schmitz F, Malenka RC, Südhof TC | title = RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone | journal = Nature | volume = 415 | issue = 6869 | pages = 321–6 | year = 2002 | pmid = 11797009 | doi = 10.1038/415321a | bibcode = 2002Natur.415..321S | s2cid = 4424128 }}
• {{cite journal | vauthors = Ohtsuka T, Takao-Rikitsu E, Inoue E, Inoue M, Takeuchi M, Matsubara K, Deguchi-Tawarada M, Satoh K, Morimoto K, Nakanishi H, Takai Y | title = Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1 | journal = J. Cell Biol. | volume = 158 | issue = 3 | pages = 577–90 | year = 2002 | pmid = 12163476 | pmc = 2173811 | doi = 10.1083/jcb.200202083 }}
• {{cite journal | vauthors = Sheu L, Pasyk EA, Ji J, Huang X, Gao X, Varoqueaux F, Brose N, Gaisano HY | title = Regulation of insulin exocytosis by Munc13-1 | journal = J. Biol. Chem. | volume = 278 | issue = 30 | pages = 27556–63 | year = 2003 | pmid = 12871971 | doi = 10.1074/jbc.M303203200 | doi-access = free }}
• {{cite journal | vauthors = Cheviet S, Coppola T, Haynes LP, Burgoyne RD, Regazzi R | title = The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis | journal = Mol. Endocrinol. | volume = 18 | issue = 1 | pages = 117–26 | year = 2004 | pmid = 14593078 | doi = 10.1210/me.2003-0300 | doi-access = free }}
• {{cite journal | vauthors = Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S | title = Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions | journal = Genome Res. | volume = 14 | issue = 9 | pages = 1711–8 | year = 2004 | pmid = 15342556 | pmc = 515316 | doi = 10.1101/gr.2435604 }}
• {{cite journal | vauthors = Yamamoto K, Ishii E, Sako M, Ohga S, Furuno K, Suzuki N, Ueda I, Imayoshi M, Yamamoto S, Morimoto A, Takada H, Hara T, Imashuku S, Sasazuki T, Yasukawa M | title = Identification of novel MUNC13-4 mutations in familial haemophagocytic lymphohistiocytosis and functional analysis of MUNC13-4-deficient cytotoxic T lymphocytes | journal = J. Med. Genet. | volume = 41 | issue = 10 | pages = 763–7 | year = 2005 | pmid = 15466010 | pmc = 1735600 | doi = 10.1136/jmg.2004.021121 }}
• {{cite journal | vauthors = Speight P, Silverman M | title = Diacylglycerol-activated Hmunc13 serves as an effector of the GTPase Rab34 | journal = Traffic | volume = 6 | issue = 10 | pages = 858–65 | year = 2005 | pmid = 16138900 | doi = 10.1111/j.1600-0854.2005.00321.x | s2cid = 41859546 | doi-access = free }}

{{Refend}}

{{Gene-9-stub}}