DVL1

DVL1, the human homolog of the Drosophila dishevelled gene (dsh), encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for processes involved in cell transformations involved in neuroblastoma. The Schwartz–Jampel syndrome and Charcot–Marie–Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. Three transcript variants encoding three different isoforms have been found for this gene.

DVL1 has been shown to interact with:

• AXIN1,{{cite journal | vauthors = Li L, Yuan H, Weaver CD, Mao J, Farr GH, Sussman DJ, Jonkers J, Kimelman D, Wu D | title = Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1 | journal = EMBO J. | volume = 18 | issue = 15 | pages = 4233–40 | date = Aug 1999 | pmid = 10428961 | pmc = 1171499 | doi = 10.1093/emboj/18.15.4233 }}{{cite journal | vauthors = Kim MJ, Chia IV, Costantini F | title = SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability | journal = FASEB J. | volume = 22 | issue = 11 | pages = 3785–94 | date = Nov 2008 | pmid = 18632848 | pmc = 2574027 | doi = 10.1096/fj.08-113910 | doi-access = free }}
• DVL3,{{cite journal | vauthors = Kishida S, Yamamoto H, Hino S, Ikeda S, Kishida M, Kikuchi A | title = DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability | journal = Mol. Cell. Biol. | volume = 19 | issue = 6 | pages = 4414–22 | date = Jun 1999 | pmid = 10330181 | pmc = 104400 | doi = 10.1128/mcb.19.6.4414}}
• EPS8,{{cite journal | vauthors = Inobe M, ((Katsube Ki)), Miyagoe Y, ((Nabeshima Yi)), Takeda S | title = Identification of EPS8 as a Dvl1-associated molecule | journal = Biochem. Biophys. Res. Commun. | volume = 266 | issue = 1 | pages = 216–21 | date = Dec 1999 | pmid = 10581192 | doi = 10.1006/bbrc.1999.1782 }} and
• Mothers against decapentaplegic homolog 3.{{cite journal | vauthors = Warner DR, Pisano MM, Roberts EA, Greene RM | title = Identification of three novel Smad binding proteins involved in cell polarity | journal = FEBS Lett. | volume = 539 | issue = 1–3 | pages = 167–73 | date = Mar 2003 | pmid = 12650946 | doi = 10.1016/s0014-5793(03)00155-8| doi-access = free | bibcode = 2003FEBSL.539..167W }}

• Dishevelled

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• {{cite journal | vauthors = Wharton KA | title = Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction | journal = Dev. Biol. | volume = 253 | issue = 1 | pages = 1–17 | year = 2003 | pmid = 12490194 | doi = 10.1006/dbio.2002.0869 | doi-access = free }}
• {{cite journal | vauthors = Klingensmith J, Nusse R, Perrimon N | title = The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal | journal = Genes Dev. | volume = 8 | issue = 1 | pages = 118–30 | year = 1994 | pmid = 8288125 | doi = 10.1101/gad.8.1.118 | doi-access = free }}
• {{cite journal | vauthors = Pizzuti A, Novelli G, Mari A, Ratti A, Colosimo A, Amati F, Penso D, Sangiuolo F, Calabrese G, Palka G, Silani V, Gennarelli M, Mingarelli R, Scarlato G, Scambler P, Dallapiccola B | title = Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome | journal = Am. J. Hum. Genet. | volume = 58 | issue = 4 | pages = 722–9 | year = 1996 | pmid = 8644734 | pmc = 1914677 }}
• {{cite journal | vauthors = Steitz SA, Tsang M, Sussman DJ | title = Wnt-mediated relocalization of dishevelled proteins | journal = In Vitro Cell. Dev. Biol. Anim. | volume = 32 | issue = 7 | pages = 441–5 | year = 1997 | pmid = 8856345 | doi = 10.1007/BF02723007 | s2cid = 20740333 }}
• {{cite journal | vauthors = Semënov MV, Snyder M | title = Human dishevelled genes constitute a DHR-containing multigene family | journal = Genomics | volume = 42 | issue = 2 | pages = 302–10 | year = 1997 | pmid = 9192851 | doi = 10.1006/geno.1997.4713 | doi-access = free }}
• {{cite journal | vauthors = Bui TD, Beier DR, Jonssen M, Smith K, Dorrington SM, Kaklamanis L, Kearney L, Regan R, Sussman DJ, Harris AL | title = cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas | journal = Biochem. Biophys. Res. Commun. | volume = 239 | issue = 2 | pages = 510–6 | year = 1997 | pmid = 9344861 | doi = 10.1006/bbrc.1997.7500 }}
• {{cite journal | vauthors = Ikeda S, Kishida S, Yamamoto H, Murai H, Koyama S, Kikuchi A | title = Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin | journal = EMBO J. | volume = 17 | issue = 5 | pages = 1371–84 | year = 1998 | pmid = 9482734 | pmc = 1170485 | doi = 10.1093/emboj/17.5.1371 }}
• {{cite journal | vauthors = Kishida S, Yamamoto H, Hino S, Ikeda S, Kishida M, Kikuchi A | title = DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability | journal = Mol. Cell. Biol. | volume = 19 | issue = 6 | pages = 4414–22 | year = 1999 | pmid = 10330181 | pmc = 104400 | doi = 10.1128/mcb.19.6.4414}}
• {{cite journal | vauthors = Fagotto F, ((Jho Eh)), Zeng L, Kurth T, Joos T, Kaufmann C, Costantini F | title = Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization | journal = J. Cell Biol. | volume = 145 | issue = 4 | pages = 741–56 | year = 1999 | pmid = 10330403 | pmc = 2133179 | doi = 10.1083/jcb.145.4.741 }}
• {{cite journal | vauthors = Li L, Yuan H, Weaver CD, Mao J, Farr GH, Sussman DJ, Jonkers J, Kimelman D, Wu D | title = Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1 | journal = EMBO J. | volume = 18 | issue = 15 | pages = 4233–40 | year = 1999 | pmid = 10428961 | pmc = 1171499 | doi = 10.1093/emboj/18.15.4233 }}
• {{cite journal | vauthors = Strovel ET, Wu D, Sussman DJ | title = Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription | journal = J. Biol. Chem. | volume = 275 | issue = 4 | pages = 2399–403 | year = 2000 | pmid = 10644691 | doi = 10.1074/jbc.275.4.2399 | doi-access = free }}
• {{cite journal | vauthors = Song DH, Sussman DJ, Seldin DC | title = Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells | journal = J. Biol. Chem. | volume = 275 | issue = 31 | pages = 23790–7 | year = 2000 | pmid = 10806215 | doi = 10.1074/jbc.M909107199 | doi-access = free }}
• {{cite journal | vauthors = Hino S, Kishida S, Michiue T, Fukui A, Sakamoto I, Takada S, Asashima M, Kikuchi A | title = Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein | journal = Mol. Cell. Biol. | volume = 21 | issue = 1 | pages = 330–42 | year = 2001 | pmid = 11113207 | pmc = 88806 | doi = 10.1128/MCB.21.1.330-342.2001 }}
• {{cite journal | vauthors = Rubinfeld B, Tice DA, Polakis P | title = Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon | journal = J. Biol. Chem. | volume = 276 | issue = 42 | pages = 39037–45 | year = 2001 | pmid = 11487578 | doi = 10.1074/jbc.M105148200 | doi-access = free }}
• {{cite journal | vauthors = Chen W, Hu LA, Semenov MV, Yanagawa S, Kikuchi A, Lefkowitz RJ, Miller WE | title = beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 26 | pages = 14889–94 | year = 2002 | pmid = 11742073 | pmc = 64954 | doi = 10.1073/pnas.211572798 | bibcode = 2001PNAS...9814889C | doi-access = free }}
• {{cite journal | vauthors = Habas R, Kato Y, He X | title = Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1 | journal = Cell | volume = 107 | issue = 7 | pages = 843–54 | year = 2002 | pmid = 11779461 | doi = 10.1016/S0092-8674(01)00614-6 | s2cid = 16894557 | doi-access = free }}
• {{cite journal | vauthors = Russ C, Lovestone S, Powell JF | title = Identification of genomic organisation, sequence variants and analysis of the role of the human dishevelled 1 gene in late onset Alzheimer's disease | journal = Mol. Psychiatry | volume = 7 | issue = 1 | pages = 104–9 | year = 2002 | pmid = 11803455 | doi = 10.1038/sj/mp/4000941 | doi-access = free }}
• {{cite journal | vauthors = Gao ZH, Seeling JM, Hill V, Yochum A, Virshup DM | title = Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 3 | pages = 1182–7 | year = 2002 | pmid = 11818547 | pmc = 122164 | doi = 10.1073/pnas.032468199 | bibcode = 2002PNAS...99.1182G | doi-access = free }}

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• [http://atlasgeneticsoncology.org/Genes/DVL1ID463ch1p36.html DVL1] on the Atlas of Genetics and Oncology

{{PDB Gallery|geneid=1855}}

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