DVL3
{{Short description|Protein-coding gene in humans}}
{{Infobox_gene}}
Segment polarity protein dishevelled homolog DVL-3 is a protein that in humans is encoded by the DVL3 gene.{{cite journal | vauthors = Pizzuti A, Amati F, Calabrese G, Mari A, Colosimo A, Silani V, Giardino L, Ratti A, Penso D, Calza L, Palka G, Scarlato G, Novelli G, Dallapiccola B | title = cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene | journal = Hum Mol Genet | volume = 5 | issue = 7 | pages = 953–958 |date=January 1997 | pmid = 8817329 | doi =10.1093/hmg/5.7.953 | doi-access = free }}{{cite web | title = Entrez Gene: DVL3 dishevelled, dsh homolog 3 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1857}}
This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation.
Interactions
DVL3 has been shown to interact with DAB2,{{cite journal |last=Hocevar |first=B A |author2=Mou F |author3=Rennolds J L |author4=Morris S M |author5=Cooper J A |author6=Howe P H |date=June 2003 |title=Regulation of the Wnt signaling pathway by disabled-2 (Dab2) |journal=EMBO J. |volume=22 |issue=12 |pages=3084–3094 |location = England| issn = 0261-4189| pmid = 12805222 |doi = 10.1093/emboj/cdg286 |pmc=162138 }} DVL1{{cite journal |last=Kishida |first=S |author2=Yamamoto H |author3=Hino S |author4=Ikeda S |author5=Kishida M |author6=Kikuchi A |date=June 1999 |title=DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability |journal=Mol. Cell. Biol. |volume=19 |issue=6 |pages=4414–4422 |location = UNITED STATES| issn = 0270-7306| pmid = 10330181 |pmc=104400 | doi=10.1128/mcb.19.6.4414}} and PRPF3.{{cite journal |last=Rual |first=Jean-François |author2=Venkatesan Kavitha |author3=Hao Tong |author4=Hirozane-Kishikawa Tomoko |author5=Dricot Amélie |author6=Li Ning |author7=Berriz Gabriel F |author8=Gibbons Francis D |author9=Dreze Matija |author10=Ayivi-Guedehoussou Nono |author11=Klitgord Niels |author12=Simon Christophe |author13=Boxem Mike |author14=Milstein Stuart |author15=Rosenberg Jennifer |author16=Goldberg Debra S |author17=Zhang Lan V |author18=Wong Sharyl L |author19=Franklin Giovanni |author20=Li Siming |author21=Albala Joanna S |author22=Lim Janghoo |author23=Fraughton Carlene |author24=Llamosas Estelle |author25=Cevik Sebiha |author26=Bex Camille |author27=Lamesch Philippe |author28=Sikorski Robert S |author29=Vandenhaute Jean |author30=Zoghbi Huda Y |author31=Smolyar Alex |author32=Bosak Stephanie |author33=Sequerra Reynaldo |author34=Doucette-Stamm Lynn |author35=Cusick Michael E |author36=Hill David E |author37=Roth Frederick P |author38=Vidal Marc |date=October 2005 |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue=7062 |pages=1173–1178 |location = England| pmid = 16189514 |doi = 10.1038/nature04209 | bibcode =2005Natur.437.1173R |s2cid=4427026 }}
See also
References
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Further reading
{{refbegin | 2}}
- {{cite journal | vauthors=Nagase T, Seki N, Ishikawa K |title=Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain |journal=DNA Res. |volume=3 |issue= 5 |pages= 321–329, 341–54 |year= 1997 |pmid= 9039502 |doi=10.1093/dnares/3.5.321 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Semënov MV, Snyder M |title=Human dishevelled genes constitute a DHR-containing multigene family |journal=Genomics |volume=42 |issue= 2 |pages= 302–310 |year= 1997 |pmid= 9192851 |doi= 10.1006/geno.1997.4713 |doi-access= free }}
- {{cite journal | vauthors=Bui TD, Beier DR, Jonssen M |title=cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas |journal=Biochem. Biophys. Res. Commun. |volume=239 |issue= 2 |pages= 510–516 |year= 1997 |pmid= 9344861 |doi= 10.1006/bbrc.1997.7500 |display-authors=etal}}
- {{cite journal | vauthors=Kishida S, Yamamoto H, Hino S |title=DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability |journal=Mol. Cell. Biol. |volume=19 |issue= 6 |pages= 4414–4422 |year= 1999 |pmid= 10330181 |doi= 10.1128/mcb.19.6.4414| pmc=104400 |display-authors=etal}}
- {{cite journal | vauthors=Song DH, Sussman DJ, Seldin DC |title=Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23790–23797 |year= 2000 |pmid= 10806215 |doi= 10.1074/jbc.M909107199 |doi-access= free }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | vauthors=Hocevar BA, Mou F, Rennolds JL |title=Regulation of the Wnt signaling pathway by disabled-2 (Dab2) |journal=EMBO J. |volume=22 |issue= 12 |pages= 3084–3094 |year= 2003 |pmid= 12805222 |doi= 10.1093/emboj/cdg286 | pmc=162138 |display-authors=etal}}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Torban E, Wang HJ, Groulx N, Gros P |title=Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family |journal=J. Biol. Chem. |volume=279 |issue= 50 |pages= 52703–52713 |year= 2005 |pmid= 15456783 |doi= 10.1074/jbc.M408675200 |doi-access= free }}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–1178 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal|bibcode=2005Natur.437.1173R |s2cid=4427026 }}
- {{cite journal | vauthors=Chan DW, Chan CY, Yam JW |title=Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer |journal=Gastroenterology |volume=131 |issue= 4 |pages= 1218–1227 |year= 2006 |pmid= 17030191 |doi= 10.1053/j.gastro.2006.07.020 |display-authors=etal|doi-access=free }}
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{{PDB Gallery|geneid=1857}}
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