David C. Page

Page was born in Harrisburg, Pennsylvania, in 1956 and grew up in the rural outskirts of Pennsylvania Dutch country.{{Cite journal|title = Profile of David C. Page|journal = Proceedings of the National Academy of Sciences of the United States of America|date = 2006|issn = 0027-8424|pmc = 1413862|pmid = 16481618|pages = 2471–2473|volume = 103|issue = 8|doi = 10.1073/pnas.0600615103|first = Bijal|last = Trivedi|bibcode = 2006PNAS..103.2471T|doi-access = free}}{{Cite web|title = Why, Oh Y? {{!}} The Scientist Magazine|url = http://www.the-scientist.com/?articles.view/articleNo/41689/title/Why--Oh-Y-/|website = The Scientist|access-date = 2016-02-04}}{{Cite journal|url = http://d3fnt9hd6tfohz.cloudfront.net/assets/issues/MURJ29_full.pdf|title = MURJ Spotlight: Professor David C. Page, Director of the Whitehead Institute|last1 = Jagetia|first1 = Riya|date = Spring 2015|journal = MIT Undergraduate Research Journal|access-date = 4 February 2016|last2 = Berg|first2 = Elizabeth|last3 = Kim|first3 = Jae Hyun|last4 = Jones|first4 = Brianna|url-status = dead|archive-url = https://web.archive.org/web/20160223095046/http://d3fnt9hd6tfohz.cloudfront.net/assets/issues/MURJ29_full.pdf|archive-date = 23 February 2016}} The first of his family to go to college, Page attended Swarthmore College, where he graduated with a BA with highest honors in chemistry in 1978.{{Cite web|title = DAVID PAGE LABORATORY|url = http://pagelab.wi.mit.edu/|website = pagelab.wi.mit.edu|access-date = 2016-02-04}} During his final year at Swarthmore, Page attended class just one day a week and spent the rest of his time researching chromatin structure in the laboratory of molecular biologist Robert Simpson at the National Institutes of Health. In 1978, Page enrolled at Harvard Medical School and the Harvard-MIT Health Sciences Program, where he worked in the laboratories of David Botstein at MIT and Raymond White at the University of Massachusetts Medical School. In White's lab, Page worked on a project to develop a genetic linkage map of the human genome that would become a precursor to the Human Genome Project. The work relied on locating restriction fragment length polymorphisms (RFLP). The first RFLP that Page found was from a site of homology between the X chromosome and Y chromosome, a coincidence that would set the direction of his subsequent career.

Page finished his MD degree in the spring of 1984 and started his own lab as the first Whitehead Fellow at the Whitehead Institute for Biomedical Research researching the genetics of XX male syndrome, or de la Chapelle Syndrome. After Page won the MacArthur "Genius Grant" in 1986, Page was promoted to the faculty of the Whitehead Institute and the MIT Department of Biology in 1988.{{Cite journal|url = http://bulletin.swarthmore.edu/bulletin-issue-archive/wp-content/archived_issues_pdf/Bulletin_1999_09.pdf|title = Save the males: David Page '78 reveals the evolutionary roots of sex and gender|last = Cruzan Morton|first = Carol|date = September 1999|journal = Swarthmore Bulletin|access-date = 4 February 2016}} In 1990, Page was named a Howard Hughes Medical Institute Investigator, and in 2005 he was named as director of the Whitehead Institute.

Page has worked in several areas of genetics.{{Google scholar id}}{{Cite news|url=https://www.nytimes.com/2009/09/15/science/15chrom.html|title=New Clues to Sex Anomalies in How Y Chromosomes Are Copied|first=Nicholas|last=Wade|work=The New York Times |date=September 14, 2009|via=NYTimes.com}}

In his work on de la Chapelle Syndrome in 1986, Page collaborated with the geneticist who originally identified the first XX male, Albert de la Chapelle, and geneticist Jean Weissenbach to show that XX males carry a small piece of the Y chromosome.{{Cite journal|title = Chromosome Y-specific DNA in related human XX males|journal = Nature|date = 1985-05-16|issn = 0028-0836|pmid = 2987697|pages = 224–226|volume = 315|issue = 6016|first1 = D. C.|last1 = Page|first2 = A.|last2 = de la Chapelle|first3 = J.|last3 = Weissenbach|doi=10.1038/315224a0|bibcode = 1985Natur.315..224P|s2cid = 4344130}}{{Cite journal|title = Chromosome Y-specific DNA is transferred to the short arm of X chromosome in human XX males|journal = Science|date = 1986-08-15|issn = 0036-8075|pmid = 3738510|pages = 786–788|volume = 233|issue = 4765|first1 = M.|last1 = Andersson|first2 = D. C.|last2 = Page|first3 = A.|last3 = de la Chapelle|doi=10.1126/science.3738510|bibcode = 1986Sci...233..786A|s2cid = 32456133}}

In the following year, he reported that the gene ZFY induced the development of the testes, a finding which received a great deal of media attention since it putatively resolving a decade-long search for the sex-determining gene.{{Cite journal|title = The sex-determining region of the human Y chromosome encodes a finger protein|journal = Cell|date = 1987-12-24|issn = 0092-8674|pmid = 3690661|pages = 1091–1104|volume = 51|issue = 6|first1 = D. C.|last1 = Page|first2 = R.|last2 = Mosher|first3 = E. M.|last3 = Simpson|first4 = E. M.|last4 = Fisher|first5 = G.|last5 = Mardon|first6 = J.|last6 = Pollack|first7 = B.|last7 = McGillivray|first8 = A.|last8 = de la Chapelle|first9 = L. G.|last9 = Brown|doi=10.1016/0092-8674(87)90595-2|s2cid = 7454260}} In 1989, a British team of scientists led by Peter Goodfellow and Robin Lovell-Badge began to report that the testis-determining gene was not ZFY, which led Page to review his data. Page found that he had misinterpreted his data because one of the XY females in his study had a second deletion at the site which proved to be the location of the real sex-determining gene. Launching a second round of media attention, Nature published his findings together with a paper from the British group that identified the sex-determining gene, which they termed SRY.{{Cite journal|title = A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif|journal = Nature|date = 1990-07-19|issn = 0028-0836|pmid = 1695712|pages = 240–244|volume = 346|issue = 6281|doi = 10.1038/346240a0|first1 = A. H.|last1 = Sinclair|first2 = P.|last2 = Berta|first3 = M. S.|last3 = Palmer|first4 = J. R.|last4 = Hawkins|first5 = B. L.|last5 = Griffiths|first6 = M. J.|last6 = Smith|first7 = J. W.|last7 = Foster|first8 = A. M.|last8 = Frischauf|first9 = R.|last9 = Lovell-Badge|bibcode = 1990Natur.346..240S|s2cid = 4364032|url = http://rcin.org.pl/Content/66315}}

Despite a belief among geneticists that the Y chromosome contained few genes other than the sex-determining gene, Page continued to map the Y chromosome. He had already published DNA-based deletion maps of the Y chromosome in 1986,{{Cite journal|title = A deletion map of the human Y chromosome based on DNA hybridization.|journal = American Journal of Human Genetics|date = 1986-02-01|issn = 0002-9297|pmc = 1684749|pmid = 3004206|pages = 109–124|volume = 38|issue = 2|first1 = G|last1 = Vergnaud|first2 = D C|last2 = Page|first3 = M C|last3 = Simmler|first4 = L|last4 = Brown|first5 = F|last5 = Rouyer|first6 = B|last6 = Noel|first7 = D|last7 = Botstein|first8 = A|last8 = de la Chapelle|first9 = J|last9 = Weissenbach}} and went on to develop comprehensive clone-based physical maps of the chromosome in 1992{{Cite journal|url = http://pagelab.wi.mit.edu/pdf/1992%20-%20The%20human%20Y%20chromosome%20-%20a%2043-interval%20map%20based%20on%20naturally%20occurring%20deletions.pdf|title = The Human Y Chromosome: A 43-Interval Map Based on Naturally Occurring Deletions|last1 = Vollrath|first1 = Douglas|date = 2 October 1992|journal = Science|doi = 10.1126/science.1439769|pmid = 1439769|access-date = 4 February 2016|last2 = Foote|first2 = Simon|last3 = Hilton|first3 = Adrienne|last4 = Brown|first4 = Laura G.|last5 = Beer-Romero|first5 = Peggy|last6 = Bogan|first6 = Jonathan|last7 = Page|first7 = David C.|issue = 5079|volume = 258|pages = 52–59|bibcode = 1992Sci...258...52V}}{{Cite journal|url = http://pagelab.wi.mit.edu/pdf/1992%20-%20The%20human%20Y%20chromosome%20-%20overlapping%20DNA%20clones%20spanning%20the%20euchromatic%20region.pdf|title = The Human Y Chromosome: Spanning the Euchromatic Region|last1 = Foote|first1 = Simon|date = 2 October 1992|journal = Science|doi = 10.1126/science.1359640|pmid = 1359640|access-date = 4 February 2016|last2 = Vollrath|first2 = Douglas|last3 = Hilton|first3 = Adrienne|last4 = Page|first4 = David C.|issue = 5079|volume = 258|pages = 60–66}} and systematic catalogs of Y-linked genes in 1997.{{Cite journal|url = http://pagelab.wi.mit.edu/pdf/1997%20-%20Functional%20coherence%20of%20the%20human%20Y%20chromosome.pdf|title = Functional Coherence of the Human Y Chromosome|last1 = Lahn|first1 = Bruce|date = 24 October 1997|journal = Science|doi = 10.1126/science.278.5338.675|pmid = 9381176|access-date = 4 February 2016|last2 = Page|first2 = David C.|issue = 5338|volume = 278|pages = 675–680|bibcode = 1997Sci...278..675L}} Page collaborated with a team at the Genome Institute at Washington University to make a complete map of the Y chromosome, which they achieved in 2003.{{Cite journal |last1 = Skaletsky|first1 = H.|last2 = Kuroda-Kawaguchi|first2 = T.|last3 = Minx|first3 = P. J.|last4 = Cordum|first4 = H. S.|last5 = Hillier|first5 = L.|last6 = Brown|first6 = L. G.|last7 = Repping|first7 = S.|last8 = Pyntikova|first8 = T.|last9 = Ali|first9 = J.|last10 = Bieri|doi = 10.1038/nature01722|first10 = T.|last11 = Chinwalla|first11 = A.|last12 = Delehaunty|first12 = A.|last13 = Delehaunty|first13 = K.|last14 = Du|first14 = H.|last15 = Fewell|first15 = G.|last16 = Fulton|first16 = L.|last17 = Fulton|first17 = R.|last18 = Graves|first18 = T.|last19 = Hou|first19 = S. F.|last20 = Latrielle|first20 = P.|last21 = Leonard|first21 = S.|last22 = Mardis|first22 = E.|last23 = Maupin|first23 = R.|last24 = McPherson|first24 = J.|last25 = Miner|first25 = T.|last26 = Nash|first26 = W.|last27 = Nguyen|first27 = C.|last28 = Ozersky|first28 = P.|last29 = Pepin|first29 = K.|last30 = Rock|first30 = S.|title = The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes|journal = Nature|volume = 423|issue = 6942|pages = 825–837|year = 2003|pmid = 12815422|bibcode = 2003Natur.423..825S|doi-access = free}} To do so, Page and his colleagues developed a new sequencing technique, single-haplotype iterative mapping and sequencing (SHIMS), since mammalian sex chromosomes contain too many repetitive sequences to be sequenced by conventional approaches. The development of SHIMS allowed Page to identify long palindromic sequences on the long arm of the Y chromosome, which he would go on to show made the Y chromosome vulnerable to the deletions that cause spermatogenic failure (an inability to produce sperm).{{Cite journal|title = Recombination between palindromes P5 and P1 on the human Y chromosome causes massive deletions and spermatogenic failure|journal = American Journal of Human Genetics|date = 2002-10-01|issn = 0002-9297|pmc = 419997|pmid = 12297986|pages = 906–922|volume = 71|issue = 4|doi = 10.1086/342928|first1 = Sjoerd|last1 = Repping|first2 = Helen|last2 = Skaletsky|first3 = Julian|last3 = Lange|first4 = Sherman|last4 = Silber|first5 = Fulco|last5 = Van Der Veen|first6 = Robert D.|last6 = Oates|first7 = David C.|last7 = Page|first8 = Steve|last8 = Rozen}} In 2012, Page characterized the most common genetic cause of spermatogenic failure, the deletion of the AZFc region of the Y chromosome.{{Cite web|url=http://wi.mit.edu/people/faculty|title=Whitehead Institute - Faculty|website=wi.mit.edu|date=22 May 2024 }}{{Cite journal|title = AZFc deletions and spermatogenic failure: a population-based survey of 20,000 Y chromosomes|journal = American Journal of Human Genetics|date = 2012-11-02|issn = 1537-6605|pmc = 3487143|pmid = 23103232|pages = 890–896|volume = 91|issue = 5|doi = 10.1016/j.ajhg.2012.09.003|first1 = Steven G.|last1 = Rozen|first2 = Janet D.|last2 = Marszalek|first3 = Kathryn|last3 = Irenze|first4 = Helen|last4 = Skaletsky|first5 = Laura G.|last5 = Brown|first6 = Robert D.|last6 = Oates|first7 = Sherman J.|last7 = Silber|first8 = Kristin|last8 = Ardlie|first9 = David C.|last9 = Page}} The lab also found that aberrant crossing over within the Y chromosome's palindromes underlies a wide range of disorders of sexual differentiation, including Turner syndrome.

With the development of more detailed maps of the Y chromosome, in the mid-1990s Page began to find genetic evidence confirming the theory that both the X and Y chromosomes had evolved from autosomes, beginning with the 1996 discovery that a family of genes called DAZ (deleted in azoospermia) had been transposed from an autosome to the Y chromosome.{{Cite journal|title = The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned|journal = Nature Genetics|date = 1996-11-01|issn = 1061-4036|pmid = 8896558|pages = 292–299|volume = 14|issue = 3|doi = 10.1038/ng1196-292|first1 = R.|last1 = Saxena|first2 = L. G.|last2 = Brown|first3 = T.|last3 = Hawkins|first4 = R. K.|last4 = Alagappan|first5 = H.|last5 = Skaletsky|first6 = M. P.|last6 = Reeve|first7 = R.|last7 = Reijo|first8 = S.|last8 = Rozen|first9 = M. B.|last9 = Dinulos|s2cid = 34964224}} In 1999, Page and his then-graduate student Bruce Lahn showed that the X and Y chromosomes had diverged in four steps, beginning 200-300 million years ago.{{Cite journal|title = Four evolutionary strata on the human X chromosome|journal = Science|date = 1999-10-29|issn = 0036-8075|pmid = 10542153|pages = 964–967|volume = 286|issue = 5441|first1 = B. T.|last1 = Lahn|first2 = D. C.|last2 = Page|doi=10.1126/science.286.5441.964}} Later cross-species comparisons would show that while ancestral genes on the Y chromosome initially underwent rapid decay,{{Cite journal|title = Convergent evolution of chicken Z and human X chromosomes by expansion and gene acquisition|journal = Nature|date = 2010-07-29|issn = 1476-4687|pmc = 2943333|pmid = 20622855|pages = 612–616|volume = 466|issue = 7306|doi = 10.1038/nature09172|first1 = Daniel W.|last1 = Bellott|first2 = Helen|last2 = Skaletsky|first3 = Tatyana|last3 = Pyntikova|first4 = Elaine R.|last4 = Mardis|first5 = Tina|last5 = Graves|first6 = Colin|last6 = Kremitzki|first7 = Laura G.|last7 = Brown|first8 = Steve|last8 = Rozen|first9 = Wesley C.|last9 = Warren|bibcode = 2010Natur.466..612B|url = http://dspace.mit.edu/bitstream/1721.1/66578/1/050610_Submitted.pdf}} the remaining genes have remained stable for the last 25 million years,{{Cite journal|title = Strict evolutionary conservation followed rapid gene loss on human and rhesus Y chromosomes|journal = Nature|date = 2012-03-01|issn = 0028-0836|pmc = 3292678|pmid = 22367542|pages = 82–86|volume = 483|issue = 7387|doi = 10.1038/nature10843|language = en|first1 = Jennifer F.|last1 = Hughes|first2 = Helen|last2 = Skaletsky|first3 = Laura G.|last3 = Brown|first4 = Tatyana|last4 = Pyntikova|first5 = Tina|last5 = Graves|first6 = Robert S.|last6 = Fulton|first7 = Shannon|last7 = Dugan|first8 = Yan|last8 = Ding|first9 = Christian J.|last9 = Buhay|bibcode = 2012Natur.483...82H}} overturning the long-held view that the Y chromosome was going extinct. In a 2014 study, Page concluded that the conserved genes on the Y chromosome played an important role in male viability, since they were dosage-dependent genes with similar but not identical counterparts on the X chromosome that all have regulatory roles in transcription, translation, and protein stability. Because these genes are expressed throughout the body, Page further concluded that these genes give rise to differences in the biochemistry of male and female tissues.{{Cite journal|title = Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators|journal = Nature|date = 2014-04-24|issn = 0028-0836|pmc = 4139287|pmid = 24759411|pages = 494–499|volume = 508|issue = 7497|doi = 10.1038/nature13206|language = en|first1 = Daniel W.|last1 = Bellott|first2 = Jennifer F.|last2 = Hughes|first3 = Helen|last3 = Skaletsky|first4 = Laura G.|last4 = Brown|first5 = Tatyana|last5 = Pyntikova|first6 = Ting-Jan|last6 = Cho|first7 = Natalia|last7 = Koutseva|first8 = Sara|last8 = Zaghlul|first9 = Tina|last9 = Graves|bibcode = 2014Natur.508..494B}}

In super-resolution studies of the sex chromosomes, Page has found evidence of an evolutionary "arms race" between the X and Y chromosomes for transmission to the next generation. In one study, Page found that human X and mouse Y chromosomes have converged, independently acquiring and amplifying gene families expressed in testicular germ cells.{{Cite journal|title = Independent specialization of the human and mouse X chromosomes for the male germ line|journal = Nature Genetics|date = 2013-09-01|issn = 1061-4036|pmc = 3758364|pmid = 23872635|pages = 1083–1087|volume = 45|issue = 9|doi = 10.1038/ng.2705|language = en|first1 = Jacob L.|last1 = Mueller|first2 = Helen|last2 = Skaletsky|first3 = Laura G.|last3 = Brown|first4 = Sara|last4 = Zaghlul|first5 = Susan|last5 = Rock|first6 = Tina|last6 = Graves|first7 = Katherine|last7 = Auger|first8 = Wesley C.|last8 = Warren|first9 = Richard K.|last9 = Wilson}} Another study found that the mouse Y chromosome had acquired and massively amplified genes homologous to the testis-expressed gene families on the mouse X chromosome.{{Cite journal|title = Sequencing the mouse Y chromosome reveals convergent gene acquisition and amplification on both sex chromosomes|journal = Cell|date = 2014-11-06|issn = 1097-4172|pmc = 4260969|pmid = 25417157|pages = 800–813|volume = 159|issue = 4|doi = 10.1016/j.cell.2014.09.052|first1 = Y. Q. Shirleen|last1 = Soh|first2 = Jessica|last2 = Alföldi|first3 = Tatyana|last3 = Pyntikova|first4 = Laura G.|last4 = Brown|first5 = Tina|last5 = Graves|first6 = Patrick J.|last6 = Minx|first7 = Robert S.|last7 = Fulton|first8 = Colin|last8 = Kremitzki|first9 = Natalia|last9 = Koutseva}}

Page used the mouse as a model to study the genetics of meiotic initiation, showing that retinoic acid (RA) is the key factor which induces meiosis, as well as identifying several important genes crucial to the meiotic initiation pathway, including Stra8 and DAZL.{{Cite journal|title = In germ cells of mouse embryonic ovaries, the decision to enter meiosis precedes premeiotic DNA replication|journal = Nature Genetics|date = 2006-12-01|issn = 1061-4036|pmid = 17115059|pages = 1430–1434|volume = 38|issue = 12|doi = 10.1038/ng1919|first1 = Andrew E.|last1 = Baltus|first2 = Douglas B.|last2 = Menke|first3 = Yueh-Chiang|last3 = Hu|first4 = Mary L.|last4 = Goodheart|first5 = Anne E.|last5 = Carpenter|first6 = Dirk G.|last6 = de Rooij|first7 = David C.|last7 = Page|s2cid = 17258424}}{{Cite journal|title = Germ Cell-Intrinsic and -Extrinsic Factors Govern Meiotic Initiation in Mouse Embryos|journal = Science|date = 2008-12-12|issn = 0036-8075|pmid = 19074348|pages = 1685–1687|volume = 322|issue = 5908|doi = 10.1126/science.1166340|language = en|first1 = Yanfeng|last1 = Lin|first2 = Mark E.|last2 = Gill|first3 = Jana|last3 = Koubova|first4 = David C.|last4 = Page|bibcode = 2008Sci...322.1685L|s2cid = 11261341}}{{Cite journal|title = Retinoic acid regulates sex-specific timing of meiotic initiation in mice|journal = Proceedings of the National Academy of Sciences of the United States of America|date = 2006-02-21|issn = 0027-8424|pmc = 1413806|pmid = 16461896|pages = 2474–2479|volume = 103|issue = 8|doi = 10.1073/pnas.0510813103|language = en|first1 = Jana|last1 = Koubova|first2 = Douglas B.|last2 = Menke|first3 = Qing|last3 = Zhou|first4 = Blanche|last4 = Capel|first5 = Michael D.|last5 = Griswold|first6 = David C.|last6 = Page|bibcode = 2006PNAS..103.2474K|doi-access = free}} Page further discovered that the differentiation germ cells into gametocytes (oocytes in females or spermatocytes in males) does not depend on meiotic initiation, as commonly thought, showing that germ cells deficient in Stra8, a gene that activates the meiotic pathway, are still capable of growth and differentiation.{{Cite journal|title = Periodic retinoic acid-STRA8 signaling intersects with periodic germ-cell competencies to regulate spermatogenesis|journal = Proceedings of the National Academy of Sciences of the United States of America|date = 2015-05-05|issn = 1091-6490|pmc = 4426408|pmid = 25902548|pages = E2347–2356|volume = 112|issue = 18|doi = 10.1073/pnas.1505683112|first1 = Tsutomu|last1 = Endo|first2 = Katherine A.|last2 = Romer|first3 = Ericka L.|last3 = Anderson|first4 = Andrew E.|last4 = Baltus|first5 = Dirk G.|last5 = de Rooij|first6 = David C.|last6 = Page|bibcode = 2015PNAS..112E2347E|doi-access = free}}{{Cite journal|title = Oocyte differentiation is genetically dissociable from meiosis in mice|journal = Nature Genetics|date = 2013-08-01|issn = 1061-4036|pmc = 3747777|pmid = 23770609|pages = 877–883|volume = 45|issue = 8|doi = 10.1038/ng.2672|language = en|first1 = Gregoriy A.|last1 = Dokshin|first2 = Andrew E.|last2 = Baltus|first3 = John J.|last3 = Eppig|first4 = David C.|last4 = Page}}

His honors and awards include:

• 1986 MacArthur Prize Fellowship{{Cite web|title = David C. Page — MacArthur Foundation|url = https://www.macfound.org/fellows/282/|website = www.macfound.org|access-date = 2016-02-04}}
• 1989 Searle Scholar Award{{Cite web|title = Searle Scholars Program : David C. Page (1989)|url = http://www.searlescholars.net/person/313|website = www.searlescholars.net|access-date = 2016-02-04}}
• 1997 Francis Amory Prize, American Academy of Arts and Sciences (for genetic studies of mammalian sex determination; prize shared with Peter Goodfellow and Robin Lovell-Badge)
• 2003 Curt Stern Award, American Society of Human Genetics (for outstanding scientific achievement in human genetics){{Cite journal|title = On Low Expectations Exceeded; or, The Genomic Salvation of the Y Chromosome|journal = American Journal of Human Genetics|date = 2004-03-01|issn = 0002-9297|pmc = 1182254|pmid = 15053010|pages = 399–402|volume = 74|issue = 3|first = David C.|last = Page|doi=10.1086/382659}}
• 2005 Member, National Academy of Sciences
• 2007 Fellow, American Association for the Advancement of Science
• 2008 Member, National Academy of Medicine{{Cite web|title = MIT Office of the Provost, Institutional Research|url = http://web.mit.edu/ir/pop/awards/iom.html|website = web.mit.edu|access-date = 2016-02-04}}
• 2011 Fellow, American Academy of Arts and Sciences (Class Speaker, Biological Sciences){{Cite web|title = Press Releases - American Academy of Arts & Sciences|url = https://www.amacad.org/content/news/pressReleases.aspx?pr=133|website = www.amacad.org|access-date = 2016-02-04}}

{{Reflist}}

{{Authority control}}

{{DEFAULTSORT:Page, David C.}}

Category:Living people

Category:Swarthmore College alumni

Category:Harvard Medical School alumni

Category:Massachusetts Institute of Technology faculty

Category:MacArthur Fellows

Category:Members of the United States National Academy of Sciences

Category:Whitehead Institute faculty

Category:Howard Hughes Medical Investigators

Category:21st-century American biologists

Category:1956 births

Category:Scientists from Pennsylvania

Category:People from Harrisburg, Pennsylvania

Category:Members of the National Academy of Medicine