Diaminopyrimidine

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Diaminopyrimidines (DAP) are a class of organic chemical compounds that include two amine groups on a pyrimidine ring.

Image:Iclaprim.svg

Image:Trimethoprim.svg

They include many dihydrofolate reductase inhibitor drugs (such as pyrimethamine, trimetrexate, and piritreximhttp://aac.asm.org/cgi/content/full/45/12/3293 {{Webarchive|url=https://web.archive.org/web/20080829133333/http://aac.asm.org/cgi/content/full/45/12/3293 |date=2008-08-29 }} "Dicyclic and Tricyclic Diaminopyrimidine Derivatives as Potent Inhibitors of Cryptosporidium parvum Dihydrofolate Reductase: Structure-Activity and Structure-Selectivity Correlations" Nelson et al. 2001 and the antibiotics iclaprim and trimethoprim).

Some have been patented as anti-cancer drugs.{{Cite web |url=http://www.wipo.int/pctdb/en/wo.jsp?IA=GB1998000111&DISPLAY=DESC |title=Archived copy |access-date=2009-01-05 |archive-url=https://web.archive.org/web/20110605164821/http://www.wipo.int/pctdb/en/wo.jsp?IA=GB1998000111&DISPLAY=DESC |archive-date=2011-06-05 |url-status=dead}}

See also

References

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Category:Aminopyrimidines

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