DnaS

{{lowercase title}}

{{Infobox protein

| Name = Deoxyuridine 5'-triphosphate nucleotidohydrolase

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| Symbol = dut

| AltSymbols = dnaS; ECK3630; JW3615; sof

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| DrugBank =

| EntrezGene = 948607

| PDB =

| RefSeq =

| UniProt = P06968

| ECnumber = 3.6.1.23

}}

dnaS or dut is a gene involved in DNA replication in Escherichia coli. It encodes dUTP nucleotidohydrolase, an enzyme responsible for catalyzing the conversion of dUTP to dUMP, thereby ensuring that the organism's DNA contains the nucleobase thymine instead of uracil.{{cite journal | vauthors = el-Hajj HH, Zhang H, Weiss B | title = Lethality of a dut (deoxyuridine triphosphatase) mutation in Escherichia coli | journal = Journal of Bacteriology | volume = 170 | issue = 3 | pages = 1069–75 | date = March 1988 | pmid = 2830228 | pmc = 210875 | doi = 10.1128/jb.170.3.1069-1075.1988 }}