Draft:Ron Kopito

Kopito earned an A.B. in biochemistry from Bowdoin College in 1976. He then received his Ph.D. in nutritional biochemistry and metabolism from the Massachusetts Institute of Technology (MIT) in 1982.{{cite web|url=https://biology.stanford.edu/people/ron-kopito|title=Stanford University Department of Biology–Ron Kopito|website=Stanford University|access-date=May 5, 2025}}

Kopito was an NIH postdoctoral fellow and Lucille P. Markey Scholar at MIT and the Whitehead Institute from 1982 to 1986 under the mentorship of Harvey F. Lodish.{{cite news|last1=Voboril| first1= Mary| date= February 28, 1985| title= Markey fellows get research awards| publisher=The Miami Herald|page=629}} In 1987, he joined the faculty of the Department of Biological Sciences (now the Department of Biology) at Stanford University, and became a full professor in 1996.{{Cite web|url=https://cap.stanford.edu/profiles/viewCV?facultyId=6227&name=Ron_Kopito|title=Ron Reiger Kopito CV|website=Stanford University|access-date=May 5, 2025}}

His research work has included genetics, cell physiological characterization of SLC4A anion transporters and the cystic fibrosis transmembrane conductance regulator, CFTR, defining the role of the ubiquitin proteasome system (UPS) in endoplasmic reticulum (ER) associated degradation (ERAD).{{cite web |title= Research - The Kopito Laboratory|url=https://www.kopitolab.com/research |website=Kopito Lab |language=en}} He coined the term aggresome{{cite journal |last1=Behl |first1=Christian |title=Breaking BAG: The Co-Chaperone BAG3 in Health and Disease |journal=Trends in Pharmacological Sciences |date=1 August 2016 |volume=37 |issue=8 |pages=672–688 |doi=10.1016/j.tips.2016.04.007 |url=https://www.sciencedirect.com/science/article/abs/pii/S0165614716300189 |issn=0165-6147}} to describe intracellular inclusions that collect aggregated proteins and demonstrated that protein aggregates derived from the Huntington's disease gene product impair cellular proteostasis and can propagate between cells in a prion-like manner.{{cite web |title=Infectious Hereditary Illness? Insights on Huntington's Disease - Innovations Report |url=https://www.innovations-report.com/health-life/life-sciences/infectious-hereditary-illness-127032/ |website=Innovations Report|date=10 February 2009}} He discovered that UFMylation of the large ribosomal subunit is required for ribosome-associated quality control and translocon recycling at the ER,{{cite web |last1=Munich |first1=Ludwig Maximilian University of |title=Researchers reveal how cells regenerate protein factories at the endoplasmic reticulum |url=https://phys.org/news/2024-02-reveal-cells-regenerate-protein-factories.html |website= Phys Org |language=en}} resolving a 50-year-old cell biological mystery.{{cite web|url=https://humsci.stanford.edu/feature/enzyme-discovery-helps-unravel-decades-old-ribosome-mystery|title=Enzyme discovery helps unravel decades-old ribosome mystery|website=Stanford University|access-date=May 5, 2025}}

• 1985 – Lucille P. Markey Scholar Award, Massachusetts Institute of Technology{{cite web|url=https://www.nytimes.com/1985/02/10/us/16-are-given-markey-research-scholarships.html|title=16 Are Given Markey Research Scholarships|website=The New York Times|access-date=May 5, 2025}}
• 1989 – Presidential Young Investigator Award, National Science Foundation{{cite web|url=https://www.nsf.gov/awardsearch/showAward?AWD_ID=8957340&HistoricalAwards=false|title=NSF Presidential Young Investigator Award|website=National Science Foundation|access-date=May 5, 2025}}
• 1993 – Established Investigator Award, American Heart Association
• 2018 – Lifetime Fellow, American Society for Cell Biology

• {{cite journal|url=https://doi.org/10.1038/316234a0 |title=Primary structure and transmembrane orientation of the murine anion exchange protein |first1=Ron |last1=Kopito |first2=Harvey |last2=Lodish |journal=Nature |volume=316 |issue= |pages=234–238 |date=1985 |doi=10.1038/316234a0}}
• {{cite journal|url=https://doi.org/10.1016/0092-8674(89)90615-6 |title=Regulation of intracellular pH by a neuronal homolog of the erythrocyte anion exchanger |first1=Ron R. |last1=Kopito |first2=Beth S. |last2=Lee |first3=Donna M. |last3=Simmons |first4=Ann E. |last4=Lindsey |first5=Catherine W. |last5=Morgans |first6=Karin |last6=Schneider |journal=Cell |volume=59 |issue=5 |pages=927–937 |date=1989 |doi=10.1016/0092-8674(89)90615-6}}
• {{cite journal|url=https://doi.org/10.1016/0092-8674(95)90310-0 |title=Conformational states of CFTR associated with channel gating: The role of ATP binding and hydrolysis |first1=Kevin L. |last1=Gunderson |first2=Ron R. |last2=Kopito |journal=Cell |volume=82 |issue= |pages=231–239 |date=1995 |doi=10.1016/0092-8674(95)90310-0}}
• {{cite journal|url=https://doi.org/10.1016/0092-8674(95)90240-6 |title=Degradation of CFTR by the ubiquitin-proteasome pathway |first1=Cristina L. |last1=Ward |first2=Satoshi |last2=Omura |first3=Ron R. |last3=Kopito |journal=Cell |volume=83 |issue=1|pages=121–127 |date=1995 |doi=10.1016/0092-8674(95)90240-6}}
• {{cite journal |url=https://doi.org/10.1038/nature06022 |title=Global changes to the ubiquitin system in Huntington's disease |first1=Eric J. |last1=Bennett |first2=Thomas A. |last2=Shaler |first3=Ben |last3=Woodman |first4=Kwon-Yul |last4=Ryu |first5=Tatiana S. |last5=Zaitseva |first6=Christopher H. |last6=Becker |first7=Gillian P. |last7=Bates |first8=Howard |last8=Schulman |first9=Ron R. |last9=Kopito |journal=Nature |volume=448 |pages=704–708 |date=2007 |doi=10.1038/nature06022}}
• {{cite journal|url=https://doi.org/10.1038/ncomms7768 |title=Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain |first1=Margaret M. P. |last1=Pearce |first2=Ellen J. |last2=Spartz |first3=Weizhe |last3=Hong |first4=Liqun |last4=Luo |first5=Ron R. |last5=Kopito |journal=Nature Communications |volume=6 |pages=6768 |date=2015 |doi=10.1038/ncomms7768}}
• {{cite journal |title=RPL26/uL24 UFMylation is essential for ribosome-associated quality control at the endoplasmic reticulum |first1=Francesco |last1=Scavone |first2=Samantha C. |last2=Gumbin |first3=Paul A. |last3=Da Rosa |first4=Ron R. |last4=Kopito |journal=Proceedings of the National Academy of Sciences of the United States of America |volume=120 |issue=16 |pages=e2220340120 |date=2023 |doi=10.1073/pnas.2220340120 |url=https://doi.org/10.1073/pnas.2220340120}}

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{{Draft categories|

:Category:Living people

:Category:1954 births

:Category:American cell biologists

:Category:American academics

:Category:Stanford University faculty

:Category:Massachusetts Institute of Technology alumni

:Category:Bowdoin College alumni

}}