E2F3

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. Alternative gene splicing is found in the mouse homolog, but has not reported in human yet.{{cite web | title = Entrez Gene: E2F3 E2F transcription factor 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1871}}

E2F3 has been shown to interact with TFE3{{cite journal | vauthors = Giangrande PH, Hallstrom TC, Tunyaplin C, Calame K, Nevins JR | title = Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor | journal = Molecular and Cellular Biology | volume = 23 | issue = 11 | pages = 3707–20 | date = Jun 2003 | pmid = 12748276 | pmc = 155231 | doi = 10.1128/MCB.23.11.3707-3720.2003 }} and RYBP.{{cite journal | vauthors = Schlisio S, Halperin T, Vidal M, Nevins JR | title = Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function | journal = The EMBO Journal | volume = 21 | issue = 21 | pages = 5775–86 | date = Nov 2002 | pmid = 12411495 | pmc = 131074 | doi = 10.1093/emboj/cdf577 }}

• E2F

{{reflist}}

{{refbegin | 2}}

• {{cite journal | vauthors = Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S | title = Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Research | volume = 1 | issue = 5 | pages = 223–9 | year = 1995 | pmid = 7584044 | doi = 10.1093/dnares/1.5.223 | doi-access = free }}
• {{cite journal | vauthors = Wu CL, Zukerberg LR, Ngwu C, Harlow E, Lees JA | title = In vivo association of E2F and DP family proteins | journal = Molecular and Cellular Biology | volume = 15 | issue = 5 | pages = 2536–46 | date = May 1995 | pmid = 7739537 | pmc = 230484 | doi = 10.1128/mcb.15.5.2536}}
• {{cite journal|author1-link=Jan Karlseder| vauthors = Karlseder J, Rotheneder H, Wintersberger E | title = Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F | journal = Molecular and Cellular Biology | volume = 16 | issue = 4 | pages = 1659–67 | date = Apr 1996 | pmid = 8657141 | pmc = 231152 | doi = 10.1128/mcb.16.4.1659}}
• {{cite journal | vauthors = Rogers KT, Higgins PD, Milla MM, Phillips RS, Horowitz JM | title = DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 15 | pages = 7594–9 | date = Jul 1996 | pmid = 8755520 | pmc = 38791 | doi = 10.1073/pnas.93.15.7594 | bibcode = 1996PNAS...93.7594R | doi-access = free }}
• {{cite journal | vauthors = Magae J, Wu CL, Illenye S, Harlow E, Heintz NH | title = Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members | journal = Journal of Cell Science | volume = 109 | issue = 7 | pages = 1717–26 | date = Jul 1996 | doi = 10.1242/jcs.109.7.1717 | pmid = 8832394 }}
• {{cite journal | vauthors = Hofmann F, Livingston DM | title = Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit | journal = Genes & Development | volume = 10 | issue = 7 | pages = 851–61 | date = Apr 1996 | pmid = 8846921 | doi = 10.1101/gad.10.7.851 | doi-access = free }}
• {{cite journal | vauthors = Lindeman GJ, Gaubatz S, Livingston DM, Ginsberg D | title = The subcellular localization of E2F-4 is cell-cycle dependent | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 10 | pages = 5095–100 | date = May 1997 | pmid = 9144196 | pmc = 24637 | doi = 10.1073/pnas.94.10.5095 | bibcode = 1997PNAS...94.5095L | doi-access = free }}
• {{cite journal | vauthors = Dynlacht BD, Moberg K, Lees JA, Harlow E, Zhu L | title = Specific regulation of E2F family members by cyclin-dependent kinases | journal = Molecular and Cellular Biology | volume = 17 | issue = 7 | pages = 3867–75 | date = Jul 1997 | pmid = 9199321 | pmc = 232239 | doi = 10.1128/mcb.17.7.3867}}
• {{cite journal | vauthors = Pierce AM, Schneider-Broussard R, Philhower JL, Johnson DG | title = Differential activities of E2F family members: unique functions in regulating transcription | journal = Molecular Carcinogenesis | volume = 22 | issue = 3 | pages = 190–8 | date = Jul 1998 | pmid = 9688145 | doi = 10.1002/(SICI)1098-2744(199807)22:3<190::AID-MC7>3.0.CO;2-P | s2cid = 42749241 }}
• {{cite journal | vauthors = Humbert PO, Verona R, Trimarchi JM, Rogers C, Dandapani S, Lees JA | title = E2f3 is critical for normal cellular proliferation | journal = Genes & Development | volume = 14 | issue = 6 | pages = 690–703 | date = Mar 2000 | doi = 10.1101/gad.14.6.690 | pmid = 10733529 | pmc = 316459 }}
• {{cite journal | vauthors = Takahashi Y, Rayman JB, Dynlacht BD | title = Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression | journal = Genes & Development | volume = 14 | issue = 7 | pages = 804–16 | date = Apr 2000 | pmid = 10766737 | pmc = 316494 | doi = 10.1101/gad.14.7.804 }}
• {{cite journal | vauthors = Leone G, Nuckolls F, Ishida S, Adams M, Sears R, Jakoi L, Miron A, Nevins JR | title = Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins | journal = Molecular and Cellular Biology | volume = 20 | issue = 10 | pages = 3626–32 | date = May 2000 | pmid = 10779352 | pmc = 85655 | doi = 10.1128/MCB.20.10.3626-3632.2000 }}
• {{cite journal | vauthors = He Y, Armanious MK, Thomas MJ, Cress WD | title = Identification of E2F-3B, an alternative form of E2F-3 lacking a conserved N-terminal region | journal = Oncogene | volume = 19 | issue = 30 | pages = 3422–33 | date = Jul 2000 | pmid = 10918599 | doi = 10.1038/sj.onc.1203682 | doi-access = free }}
• {{cite journal | vauthors = Yamochi T, Semba K, Tsuji K, Mizumoto K, Sato H, Matsuura Y, Nishimoto I, Matsuoka M | title = ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3) | journal = European Journal of Biochemistry | volume = 268 | issue = 23 | pages = 6076–82 | date = Dec 2001 | pmid = 11733001 | doi = 10.1046/j.0014-2956.2001.02555.x }}
• {{cite journal | vauthors = Weinmann AS, Yan PS, Oberley MJ, Huang TH, Farnham PJ | title = Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis | journal = Genes & Development | volume = 16 | issue = 2 | pages = 235–44 | date = Jan 2002 | pmid = 11799066 | pmc = 155318 | doi = 10.1101/gad.943102 }}
• {{cite journal | vauthors = Ren B, Cam H, Takahashi Y, Volkert T, Terragni J, Young RA, Dynlacht BD | title = E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints | journal = Genes & Development | volume = 16 | issue = 2 | pages = 245–56 | date = Jan 2002 | pmid = 11799067 | pmc = 155321 | doi = 10.1101/gad.949802 }}
• {{cite journal | vauthors = He Y, Cress WD | title = E2F-3B is a physiological target of cyclin A | journal = The Journal of Biological Chemistry | volume = 277 | issue = 26 | pages = 23493–9 | date = Jun 2002 | pmid = 11980909 | doi = 10.1074/jbc.M202629200 | doi-access = free }}
• {{cite journal | vauthors = Schlisio S, Halperin T, Vidal M, Nevins JR | title = Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function | journal = The EMBO Journal | volume = 21 | issue = 21 | pages = 5775–86 | date = Nov 2002 | pmid = 12411495 | pmc = 131074 | doi = 10.1093/emboj/cdf577 }}

{{refend}}

• {{MeshName|E2F3+protein,+human}}

{{NLM content}}

{{Transcription factors|g3}}

Category:Transcription factors

{{gene-6-stub}}