TFE3

TFE3, a member of the helix-loop-helix family of transcription factors, binds to the mu-E3 motif of the immunoglobulin heavy-chain enhancer and is expressed in many cell types (Henthorn et al., 1991).[supplied by OMIM]

TFE3 has been shown to interact with:

• E2F3,{{cite journal | vauthors = Giangrande PH, Hallstrom TC, Tunyaplin C, Calame K, Nevins JR | title = Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor | journal = Mol. Cell. Biol. | volume = 23 | issue = 11 | pages = 3707–20 | date = Jun 2003 | pmid = 12748276 | pmc = 155231 | doi = 10.1128/mcb.23.11.3707-3720.2003}}
• Microphthalmia-associated transcription factor,{{cite journal | vauthors = Steingrimsson E, Tessarollo L, Pathak B, Hou L, Arnheiter H, Copeland NG, Jenkins NA | title = Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 7 | pages = 4477–82 | date = Apr 2002 | pmid = 11930005 | pmc = 123673 | doi = 10.1073/pnas.072071099 | bibcode = 2002PNAS...99.4477S | doi-access = free }}{{cite journal | vauthors = Mansky KC, Sulzbacher S, Purdom G, Nelsen L, Hume DA, Rehli M, Ostrowski MC | title = The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter | journal = J. Leukoc. Biol. | volume = 71 | issue = 2 | pages = 304–10 | date = Feb 2002 | doi = 10.1189/jlb.71.2.304 | pmid = 11818452 | s2cid = 22801820 | doi-access = free }} and
• Mothers against decapentaplegic homolog 3{{cite journal | vauthors = Grinberg AV, Kerppola T | title = Both Max and TFE3 cooperate with Smad proteins to bind the plasminogen activator inhibitor-1 promoter, but they have opposite effects on transcriptional activity | journal = J. Biol. Chem. | volume = 278 | issue = 13 | pages = 11227–36 | date = Mar 2003 | pmid = 12551947 | doi = 10.1074/jbc.M211734200 | doi-access = free }}{{cite journal | vauthors = Hua X, Miller ZA, Wu G, Shi Y, Lodish HF | title = Specificity in transforming growth factor beta-induced transcription of the plasminogen activator inhibitor-1 gene: interactions of promoter DNA, transcription factor muE3, and Smad proteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 23 | pages = 13130–5 | date = Nov 1999 | pmid = 10557285 | pmc = 23912 | doi = 10.1073/pnas.96.23.13130| bibcode = 1999PNAS...9613130H | doi-access = free }}

A proportion of renal carcinomas (RCC) that occur in young patients are associated with translocations involving the TFE3 gene at chromosome Xp11.2 PRCC{{citation needed|date=July 2024}}

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• {{cite journal | vauthors = Beckmann H, Kadesch T | title = The leucine zipper of TFE3 dictates helix-loop-helix dimerization specificity | journal = Genes Dev. | volume = 5 | issue = 6 | pages = 1057–66 | year = 1991 | pmid = 2044953 | doi = 10.1101/gad.5.6.1057 | doi-access = free }}
• {{cite journal | vauthors = Beckmann H, Su LK, Kadesch T | title = TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer muE3 motif | journal = Genes Dev. | volume = 4 | issue = 2 | pages = 167–79 | year = 1990 | pmid = 2338243 | doi = 10.1101/gad.4.2.167 | doi-access = free }}
• {{cite journal | vauthors = Zhao GQ, Zhao Q, Zhou X, Mattei MG, de Crombrugghe B | title = TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation | journal = Mol. Cell. Biol. | volume = 13 | issue = 8 | pages = 4505–12 | year = 1993 | pmid = 8336698 | pmc = 360062 | doi = 10.1128/mcb.13.8.4505}}
• {{cite journal | vauthors = Sidhar SK, Clark J, Gill S, Hamoudi R, Crew AJ, Gwilliam R, Ross M, Linehan WM, Birdsall S, Shipley J, Cooper CS | title = The t(X;1)(p11.2;q21.2) translocation in papillary renal cell carcinoma fuses a novel gene PRCC to the TFE3 transcription factor gene | journal = Hum. Mol. Genet. | volume = 5 | issue = 9 | pages = 1333–8 | year = 1997 | pmid = 8872474 | doi = 10.1093/hmg/5.9.1333 | doi-access = free }}
• {{cite journal | vauthors = Weterman MA, Wilbrink M, Geurts van Kessel A | title = Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)-positive papillary renal cell carcinomas | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 26 | pages = 15294–8 | year = 1997 | pmid = 8986805 | pmc = 26398 | doi = 10.1073/pnas.93.26.15294 | doi-access = free }}
• {{cite journal | vauthors = Clark J, Lu YJ, Sidhar SK, Parker C, Gill S, Smedley D, Hamoudi R, Linehan WM, Shipley J, Cooper CS | title = Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma | journal = Oncogene | volume = 15 | issue = 18 | pages = 2233–9 | year = 1997 | pmid = 9393982 | doi = 10.1038/sj.onc.1201394 | doi-access = free }}
• {{cite journal | vauthors = Hua X, Liu X, Ansari DO, Lodish HF | title = Synergistic cooperation of TFE3 and smad proteins in TGF-beta-induced transcription of the plasminogen activator inhibitor-1 gene | journal = Genes Dev. | volume = 12 | issue = 19 | pages = 3084–95 | year = 1998 | pmid = 9765209 | pmc = 317197 | doi = 10.1101/gad.12.19.3084 }}
• {{cite journal | vauthors = Steingrímsson E, Tessarollo L, Reid SW, Jenkins NA, Copeland NG | title = The bHLH-Zip transcription factor Tfeb is essential for placental vascularization | journal = Development | volume = 125 | issue = 23 | pages = 4607–16 | year = 1999 | doi = 10.1242/dev.125.23.4607 | pmid = 9806910 | doi-access = free }}
• {{cite journal | vauthors = Hua X, Miller ZA, Wu G, Shi Y, Lodish HF | title = Specificity in transforming growth factor beta-induced transcription of the plasminogen activator inhibitor-1 gene: interactions of promoter DNA, transcription factor muE3, and Smad proteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 23 | pages = 13130–5 | year = 1999 | pmid = 10557285 | pmc = 23912 | doi = 10.1073/pnas.96.23.13130 | bibcode = 1999PNAS...9613130H | doi-access = free }}
• {{cite journal | vauthors = Weterman MJ, van Groningen JJ, Jansen A, van Kessel AG | title = Nuclear localization and transactivating capacities of the papillary renal cell carcinoma-associated TFE3 and PRCC (fusion) proteins | journal = Oncogene | volume = 19 | issue = 1 | pages = 69–74 | year = 2000 | pmid = 10644981 | doi = 10.1038/sj.onc.1203255 | doi-access = free }}
• {{cite journal | vauthors = Hua X, Miller ZA, Benchabane H, Wrana JL, Lodish HF | title = Synergism between transcription factors TFE3 and Smad3 in transforming growth factor-beta-induced transcription of the Smad7 gene | journal = J. Biol. Chem. | volume = 275 | issue = 43 | pages = 33205–8 | year = 2000 | pmid = 10973944 | doi = 10.1074/jbc.C000568200 | doi-access =free }}
• {{cite journal | vauthors = Ladanyi M, Lui MY, Antonescu CR, Krause-Boehm A, Meindl A, Argani P, Healey JH, Ueda T, Yoshikawa H, Meloni-Ehrig A, Sorensen PH, Mertens F, Mandahl N, van den Berghe H, Sciot R, Dal Cin P, Bridge J | title = The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25 | journal = Oncogene | volume = 20 | issue = 1 | pages = 48–57 | year = 2001 | pmid = 11244503 | doi = 10.1038/sj.onc.1204074 | doi-access = free }}
• {{cite journal | vauthors = Weterman MA, van Groningen JJ, den Hartog A, Geurts van Kessel A | title = Transformation capacities of the papillary renal cell carcinoma-associated PRCCTFE3 and TFE3PRCC fusion genes | journal = Oncogene | volume = 20 | issue = 12 | pages = 1414–24 | year = 2001 | pmid = 11313885 | doi = 10.1038/sj.onc.1204213 | s2cid = 2671248 | doi-access = }}
• {{cite journal | vauthors = Heimann P, El Housni H, Ogur G, Weterman MA, Petty EM, Vassart G | title = Fusion of a novel gene, RCC17, to the TFE3 gene in t(X;17)(p11.2;q25.3)-bearing papillary renal cell carcinomas | journal = Cancer Res. | volume = 61 | issue = 10 | pages = 4130–5 | year = 2001 | pmid = 11358836 }}
• {{cite journal | vauthors = Chung MC, Kim HK, Kawamoto S | title = TFEC can function as a transcriptional activator of the nonmuscle myosin II heavy chain-A gene in transfected cells | journal = Biochemistry | volume = 40 | issue = 30 | pages = 8887–97 | year = 2001 | pmid = 11467950 | doi = 10.1021/bi002847d }}
• {{cite journal | vauthors = Dintilhac A, Bernués J | title = HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences | journal = J. Biol. Chem. | volume = 277 | issue = 9 | pages = 7021–8 | year = 2002 | pmid = 11748221 | doi = 10.1074/jbc.M108417200 | doi-access = free | hdl = 10261/112516 | hdl-access = free }}
• {{cite journal | vauthors = Kawata Y, Suzuki H, Higaki Y, Denisenko O, Schullery D, Abrass C, Bomsztyk K | title = bcn-1 Element-dependent activation of the laminin gamma 1 chain gene by the cooperative action of transcription factor E3 (TFE3) and Smad proteins | journal = J. Biol. Chem. | volume = 277 | issue = 13 | pages = 11375–84 | year = 2002 | pmid = 11801598 | doi = 10.1074/jbc.M111284200 | doi-access = free }}
• {{cite journal | vauthors = Steingrimsson E, Tessarollo L, Pathak B, Hou L, Arnheiter H, Copeland NG, Jenkins NA | title = Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 7 | pages = 4477–82 | year = 2002 | pmid = 11930005 | pmc = 123673 | doi = 10.1073/pnas.072071099 | bibcode = 2002PNAS...99.4477S | doi-access = free }}

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