EPN1
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Epsin-1 is a protein that in humans is encoded by the EPN1 gene.{{cite journal | vauthors = Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P | title = Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis | journal = Nature | volume = 394 | issue = 6695 | pages = 793–7 |date=Sep 1998 | pmid = 9723620 | doi = 10.1038/29555 | bibcode = 1998Natur.394..793C | s2cid = 4430975 }}{{cite journal | vauthors = Morinaka K, Koyama S, Nakashima S, Hinoi T, Okawa K, Iwamatsu A, Kikuchi A | title = Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis | journal = Oncogene | volume = 18 | issue = 43 | pages = 5915–22 |date=Dec 1999 | pmid = 10557078 | doi = 10.1038/sj.onc.1202974 | doi-access = free }}{{cite web | title = Entrez Gene: EPN1 epsin 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29924}}
EPN1 is an endocytic accessory protein that interacts with EPS15 (MIM 600051), the alpha subunit of the clathrin adaptor AP2 (AP2A1; MIM 601026), and clathrin (see MIM 118960), as well as with other accessory proteins for the endocytosis of clathrin-coated vesicles.[supplied by OMIM]
Interactions
References
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Further reading
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- {{cite journal | vauthors=Drake MT, Downs MA, Traub LM |title=Epsin binds to clathrin by associating directly with the clathrin-terminal domain. Evidence for cooperative binding through two discrete sites |journal=J. Biol. Chem. |volume=275 |issue= 9 |pages= 6479–89 |year= 2000 |pmid= 10692452 |doi=10.1074/jbc.275.9.6479 |s2cid=22584410 |url=http://www.pitt.edu/~traub/publications/6479.pdf |doi-access=free }}
- {{cite journal | author=Kariya K |title=Regulation of complex formation of POB1/epsin/adaptor protein complex 2 by mitotic phosphorylation |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18399–406 |year= 2000 |pmid= 10764745 |doi= 10.1074/jbc.M000521200 |name-list-style=vanc| author2=Koyama S | author3=Nakashima S | display-authors=3 | last4=Oshiro | first4=T | last5=Morinaka | first5=K | last6=Kikuchi | first6=A | doi-access=free}}
- {{cite journal | author=Hyman J |title=Epsin 1 Undergoes Nucleocytosolic Shuttling and Its Eps15 Interactor Nh2-Terminal Homology (Enth) Domain, Structurally Similar to Armadillo and Heat Repeats, Interacts with the Transcription Factor Promyelocytic Leukemia Zn2+ Finger Protein (Plzf) |journal=J. Cell Biol. |volume=149 |issue= 3 |pages= 537–46 |year= 2000 |pmid= 10791968 |doi=10.1083/jcb.149.3.537 | pmc=2174850 |name-list-style=vanc| author2=Chen H | author3=Di Fiore PP | display-authors=3 | last4=De Camilli | first4=P | last5=Brunger | first5=AT }}
- {{cite journal | vauthors=Drake MT, Traub LM |title=Interaction of two structurally distinct sequence types with the clathrin terminal domain beta-propeller |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 28700–9 |year= 2001 |pmid= 11382783 |doi= 10.1074/jbc.M104226200 |doi-access= free }}
- {{cite journal | author=Ford MG |title=Curvature of clathrin-coated pits driven by epsin |journal=Nature |volume=419 |issue= 6905 |pages= 361–6 |year= 2002 |pmid= 12353027 |doi= 10.1038/nature01020 |name-list-style=vanc| author2=Mills IG | author3=Peter BJ | display-authors=3 | last4=Vallis | first4=Yvonne | last5=Praefcke | first5=Gerrit J. K. | last6=Evans | first6=Philip R. | last7=McMahon | first7=Harvey T. |bibcode=2002Natur.419..361F |s2cid=4372368 }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | vauthors=Koshiba S, Kigawa T, Kikuchi A, Yokoyama S |title=Solution structure of the epsin N-terminal homology (ENTH) domain of human epsin |journal=J. Struct. Funct. Genomics |volume=2 |issue= 1 |pages= 1–8 |year= 2003 |pmid= 12836669 |doi=10.1023/A:1011397007366 |s2cid=13317798 }}
- {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-style=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }}
- {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
- {{cite journal | vauthors=Timsit YE, Miller SL, Mohney RP, O'Bryan JP |title=The U-box ligase carboxyl-terminus of Hsc 70-interacting protein ubiquitylates Epsin |journal=Biochem. Biophys. Res. Commun. |volume=328 |issue= 2 |pages= 550–9 |year= 2005 |pmid= 15694383 |doi= 10.1016/j.bbrc.2005.01.022 |url=https://zenodo.org/record/1258784 }}
- {{cite journal | author=Schmid EM |title=Role of the AP2 β-Appendage Hub in Recruiting Partners for Clathrin-Coated Vesicle Assembly |journal=PLOS Biol. |volume=4 |issue= 9 |pages= e262 |year= 2007 |pmid= 16903783 |doi= 10.1371/journal.pbio.0040262 | pmc=1540706 |name-list-style=vanc| author2=Ford MG | author3=Burtey A | display-authors=3 | last4=Praefcke | first4=Gerrit J. K. | last5=Peak-Chew | first5=Sew-Yeu | last6=Mills | first6=Ian G. | last7=Benmerah | first7=Alexandre | last8=McMahon | first8=Harvey T. |doi-access=free }}
- {{cite journal | author=Olsen JV |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |name-list-style=vanc| author2=Blagoev B | author3=Gnad F | display-authors=3 | last4=Macek | first4=Boris | last5=Kumar | first5=Chanchal | last6=Mortensen | first6=Peter | last7=Mann | first7=Matthias |s2cid=7827573 | doi-access=free}}
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{{PDB Gallery|geneid=29924}}
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