EPS15

This gene encodes a protein that is part of the EGFR pathway. The protein is present at clathrin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.{{cite web | title = Entrez Gene: EPS15 epidermal growth factor receptor pathway substrate 15| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2060}}

EPS15 has been shown to interact with:

• CRK{{cite journal | vauthors = Schumacher C, Knudsen BS, Ohuchi T, Di Fiore PP, Glassman RH, Hanafusa H | title = The SH3 domain of Crk binds specifically to a conserved proline-rich motif in Eps15 and Eps15R | journal = J. Biol. Chem. | volume = 270 | issue = 25 | pages = 15341–7 | date = June 1995 | pmid = 7797522 | doi = 10.1074/jbc.270.25.15341| doi-access = free }}
• EPN1,{{cite journal | vauthors = Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P | title = Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis | journal = Nature | volume = 394 | issue = 6695 | pages = 793–7 | date = August 1998 | pmid = 9723620 | doi = 10.1038/29555 | bibcode = 1998Natur.394..793C | s2cid = 4430975 }}
• HGS,{{cite journal | vauthors = Bean AJ, Davanger S, Chou MF, Gerhardt B, Tsujimoto S, Chang Y | title = Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15 | journal = J. Biol. Chem. | volume = 275 | issue = 20 | pages = 15271–8 | date = May 2000 | pmid = 10809762 | doi = 10.1074/jbc.275.20.15271| doi-access = free }}{{cite journal | vauthors = Bache KG, Raiborg C, Mehlum A, Stenmark H | title = STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes | journal = J. Biol. Chem. | volume = 278 | issue = 14 | pages = 12513–21 | date = April 2003 | pmid = 12551915 | doi = 10.1074/jbc.M210843200 | doi-access = free }}
• HRB,{{cite journal | vauthors = Doria M, Salcini AE, Colombo E, Parslow TG, Pelicci PG, Di Fiore PP | title = The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport | journal = J. Cell Biol. | volume = 147 | issue = 7 | pages = 1379–84 | date = December 1999 | pmid = 10613896 | pmc = 2174238 | doi = 10.1083/jcb.147.7.1379}} and
• REPS2.{{cite journal | vauthors = Nakashima S, Morinaka K, Koyama S, Ikeda M, Kishida M, Okawa K, Iwamatsu A, Kishida S, Kikuchi A | title = Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors | journal = EMBO J. | volume = 18 | issue = 13 | pages = 3629–42 | date = July 1999 | pmid = 10393179 | pmc = 1171441 | doi = 10.1093/emboj/18.13.3629 }}

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• {{cite journal | vauthors = Schumacher C, Knudsen BS, Ohuchi T, Di Fiore PP, Glassman RH, Hanafusa H | title = The SH3 domain of Crk binds specifically to a conserved proline-rich motif in Eps15 and Eps15R. | journal = J. Biol. Chem. | volume = 270 | issue = 25 | pages = 15341–7 | year = 1995 | pmid = 7797522 | doi = 10.1074/jbc.270.25.15341 | doi-access = free }}
• {{cite journal | vauthors = Bernard OA, Mauchauffe M, Mecucci C, Van den Berghe H, Berger R | title = A novel gene, AF-1p, fused to HRX in t(1;11)(p32;q23), is not related to AF-4, AF-9 nor ENL. | journal = Oncogene | volume = 9 | issue = 4 | pages = 1039–45 | year = 1994 | pmid = 8134107 }}
• {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction. | journal = Anal. Biochem. | volume = 236 | issue = 1 | pages = 107–13 | year = 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
• {{cite journal | vauthors = Benmerah A, Bégue B, Dautry-Varsat A, Cerf-Bensussan N | title = The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps 15 protein. | journal = J. Biol. Chem. | volume = 271 | issue = 20 | pages = 12111–6 | year = 1996 | pmid = 8662627 | doi = 10.1074/jbc.271.20.12111 | doi-access = free }}
• {{cite journal | vauthors = Matsuda M, Ota S, Tanimura R, Nakamura H, Matuoka K, Takenawa T, Nagashima K, Kurata T | title = Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins. | journal = J. Biol. Chem. | volume = 271 | issue = 24 | pages = 14468–72 | year = 1996 | pmid = 8662907 | doi = 10.1074/jbc.271.24.14468 | doi-access = free }}
• {{cite journal | vauthors = van Delft S, Schumacher C, Hage W, Verkleij AJ, van Bergen en Henegouwen PM | title = Association and colocalization of Eps15 with adaptor protein-2 and clathrin. | journal = J. Cell Biol. | volume = 136 | issue = 4 | pages = 811–21 | year = 1997 | pmid = 9049247 | pmc = 2132490 | doi = 10.1083/jcb.136.4.811 }}
• {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing. | journal = Genome Res. | volume = 7 | issue = 4 | pages = 353–8 | year = 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
• {{cite journal | vauthors = Tebar F, Confalonieri S, Carter RE, Di Fiore PP, Sorkin A | title = Eps15 is constitutively oligomerized due to homophilic interaction of its coiled-coil region. | journal = J. Biol. Chem. | volume = 272 | issue = 24 | pages = 15413–8 | year = 1997 | pmid = 9182572 | doi = 10.1074/jbc.272.24.15413 | doi-access = free }}
• {{cite journal | vauthors = Salcini AE, Confalonieri S, Doria M, Santolini E, Tassi E, Minenkova O, Cesareni G, Pelicci PG, Di Fiore PP | title = Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. | journal = Genes Dev. | volume = 11 | issue = 17 | pages = 2239–49 | year = 1997 | pmid = 9303539 | pmc = 275390 | doi = 10.1101/gad.11.17.2239 }}
• {{cite journal | vauthors = Cupers P, ter Haar E, Boll W, Kirchhausen T | title = Parallel dimers and anti-parallel tetramers formed by epidermal growth factor receptor pathway substrate clone 15. | journal = J. Biol. Chem. | volume = 272 | issue = 52 | pages = 33430–4 | year = 1998 | pmid = 9407139 | doi = 10.1074/jbc.272.52.33430 | doi-access = free }}
• {{cite journal | vauthors = Haffner C, Takei K, Chen H, Ringstad N, Hudson A, Butler MH, Salcini AE, Di Fiore PP, De Camilli P | title = Synaptojanin 1: localization on coated endocytic intermediates in nerve terminals and interaction of its 170 kDa isoform with Eps15. | journal = FEBS Lett. | volume = 419 | issue = 2–3 | pages = 175–80 | year = 1998 | pmid = 9428629 | doi = 10.1016/S0014-5793(97)01451-8 | s2cid = 45186831 }}
• {{cite journal | vauthors = Benmerah A, Lamaze C, Bègue B, Schmid SL, Dautry-Varsat A, Cerf-Bensussan N | title = AP-2/Eps15 interaction is required for receptor-mediated endocytosis | journal = J. Cell Biol. | volume = 140 | issue = 5 | pages = 1055–62 | year = 1998 | pmid = 9490719 | pmc = 2132690 | doi = 10.1083/jcb.140.5.1055 }}
• {{cite journal | vauthors = de Beer T, Carter RE, Lobel-Rice KE, Sorkin A, Overduin M | title = Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain | journal = Science | volume = 281 | issue = 5381 | pages = 1357–60 | year = 1998 | pmid = 9721102 | doi = 10.1126/science.281.5381.1357 | bibcode = 1998Sci...281.1357D }}
• {{cite journal | vauthors = Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P | title = Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis | journal = Nature | volume = 394 | issue = 6695 | pages = 793–7 | year = 1998 | pmid = 9723620 | doi = 10.1038/29555 | bibcode = 1998Natur.394..793C | s2cid = 4430975 }}
• {{cite journal | vauthors = Lewin DA, Sheff D, Ooi CE, Whitney JA, Yamamoto E, Chicione LM, Webster P, Bonifacino JS, Mellman I | title = Cloning, expression, and localization of a novel gamma-adaptin-like molecule | journal = FEBS Lett. | volume = 435 | issue = 2–3 | pages = 263–8 | year = 1998 | pmid = 9762922 | doi = 10.1016/S0014-5793(98)01083-7 | bibcode = 1998FEBSL.435..263L | s2cid = 83518205 }}
• {{cite journal | vauthors = Sengar AS, Wang W, Bishay J, Cohen S, Egan SE | title = The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15 | journal = EMBO J. | volume = 18 | issue = 5 | pages = 1159–71 | year = 1999 | pmid = 10064583 | pmc = 1171207 | doi = 10.1093/emboj/18.5.1159 }}
• {{cite journal | vauthors = Poupon V, Bègue B, Gagnon J, Dautry-Varsat A, Cerf-Bensussan N, Benmerah A | title = Molecular cloning and characterization of MT-ACT48, a novel mitochondrial acyl-CoA thioesterase | journal = J. Biol. Chem. | volume = 274 | issue = 27 | pages = 19188–94 | year = 1999 | pmid = 10383425 | doi = 10.1074/jbc.274.27.19188 | doi-access = free}}
• {{cite journal | vauthors = Nakashima S, Morinaka K, Koyama S, Ikeda M, Kishida M, Okawa K, Iwamatsu A, Kishida S, Kikuchi A | title = Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors | journal = EMBO J. | volume = 18 | issue = 13 | pages = 3629–42 | year = 1999 | pmid = 10393179 | pmc = 1171441 | doi = 10.1093/emboj/18.13.3629 }}
• {{cite journal | vauthors = Stephens DJ, Banting G | title = Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin | journal = J. Biol. Chem. | volume = 274 | issue = 42 | pages = 30080–6 | year = 1999 | pmid = 10514494 | doi = 10.1074/jbc.274.42.30080 | doi-access = free }}

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Category:Genes mutated in mice

Category:EH-domain-containing proteins