Estradiol/drospirenone

{{Short description|Combination drug}}

{{Drugbox

| image = Estradiol.svg

| width = 225px

| caption = Estradiol

| image2 = Drospirenone.svg

| width2 = 235px

| caption2 = Drospirenone

| type = combo

| drug_name = Estradiol/drospirenone

| component1 = Estradiol

| class1 = Estrogen

| component2 = Drospirenone

| class2 = Progestogen; Progestin; Antimineralocorticoid; Antiandrogen

| tradename = Angeliq

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| legal_US = Rx-only

| routes_of_administration = By mouth

| class = Estrogen; Progestin; Progestogen; Antimineralocorticoid; Antiandrogen

| CAS_number = 350818-73-4

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| synonyms = E2/DRSP; BAY-864891

}}

Estradiol/drospirenone (E2/DRSP), sold under the brand name Angeliq, is a combination of estradiol (E2), an estrogen, and drospirenone (DRSP), a progestin, antimineralocorticoid, and antiandrogen, which is used in menopausal hormone therapy, specifically the treatment of menopausal syndrome and osteoporosis, in postmenopausal women.{{cite web | title = ANGELIQ (drospirenone and estradiol) Prescribing Information | date = February 2012 | work = Bayer HealthCare Pharmaceuticals Inc. | publisher = U.S. Food and Drug Administration | url = https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021355s003lbl.pdf}}{{Cite web|url=https://adisinsight.springer.com/drugs/800014148|title=Estradiol/Drospirenone - Bayer HealthCare Pharmaceuticals | work = AdisInsight | publisher = }}{{cite journal | vauthors = Rosano GM, Vitale C, Marazzi G, Volterrani M | title = Menopause and cardiovascular disease: the evidence | journal = Climacteric | volume = 10 | issue = Suppl 1 | pages = 19–24 | date = February 2007 | pmid = 17364594 | doi = 10.1080/13697130601114917 | s2cid = 7305124 }} It is taken by mouth and contains 0.5 to 1 mg E2 and 0.25 to 0.5 mg DRSP per tablet. The medication was approved in the United States in 2005. It is marketed widely throughout the world.{{Cite web|url=https://www.drugs.com/ppa/drospirenone-and-estradiol.html#warnings |title = Drospirenone and Estradiol: Uses, Side Effects & Warnings}}