Ethinylestradiol/drospirenone

{{Drugbox

| type = combo

| image = Ethinylestradiol.svg

| width = 235

| caption = Ethinylestradiol

| image2 = Drospirenone.svg

| width2 = 235

| caption2 = Drospirenone

| component1 = Ethinylestradiol

| class1 = Estrogen

| component2 = Drospirenone

| class2 = Progestogen; Progestin; Antimineralocorticoid; Antiandrogen

| tradename = With 30 μg ethinylestradiol: Yasmin, others
With 20 μg ethinylestradiol: Yaz, Yasminelle, others

| Drugs.com = {{drugs.com|ppa|drospirenone-and-estradiol}}

| MedlinePlus = a601050

| DailyMedID = Drospirenone and estradiol

| pregnancy_AU = B3

| pregnancy_AU_comment = {{cite web | title=Drospirenone / estradiol (Angeliq) Use During Pregnancy | website=Drugs.com | date=6 September 2018 | url=https://www.drugs.com/pregnancy/drospirenone-estradiol.html | access-date=18 March 2020}}

| pregnancy_category=

| routes_of_administration = By mouth

| ATC_prefix = G03

| ATC_suffix = FA17

| legal_AU = S4

| legal_AU_comment = {{cite web |author=healthdirect.gov.au |title=Yasmin |url=https://www.healthdirect.gov.au/medicines/brand/amt,87053011000036107/yasmin#poisons |language=EN }}{{cite web |author=healthdirect.gov.au |title=Yaz |url=https://www.healthdirect.gov.au/medicines/brand/amt,750571000168102/yaz#poisons |language=EN }}

| legal_CA =

| legal_UK =

| legal_US = Rx-only

| legal_US_comment =

| CAS_number = 164017-31-6

| PubChem =

| DrugBank =

| KEGG = D09741

| synonyms = EE/DRSP; drospirenone/estradiol; drospirenone/ethinyl estradiol

}}

Ethinylestradiol/drospirenone (EE/DRSP), sold under the brand name Yasmin among others, is a combination of ethinylestradiol (EE), an estrogen, and drospirenone (DRSP), a progestin, antimineralocorticoid, and antiandrogen, which is used as a birth control pill to prevent pregnancy in women.{{Cite web|url=https://adisinsight.springer.com/drugs/800007379|title=Ethinylestradiol/Drospirenone | work = AdisInsight | publisher = Springer Nature Switzerland AG }}{{Cite web|url=https://adisinsight.springer.com/drugs/800017043|title=Drospirenone/Ethinylestradiol low-dose - Bayer HealthCare Pharmaceuticals | work = AdisInsight | publisher = Springer Nature Switzerland AG }}{{cite web | title=Yasmin- drospirenone and ethinyl estradiol kit | website=DailyMed | date=19 May 2023 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d7ea6a60-5a56-4f81-b206-9b27b7e58875 | access-date=26 October 2024}}{{cite web | title=Yaz- drospirenone and ethinyl estradiol kit | website=DailyMed | date=19 May 2023 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=065f33e4-b587-4e66-b896-ca9ab7b7c876 | access-date=26 October 2024}}{{cite journal | vauthors = Keam SJ, Wagstaff AJ | title = Ethinylestradiol/drospirenone: a review of its use as an oral contraceptive | journal = Treatments in Endocrinology | volume = 2 | issue = 1 | pages = 49–70 | date = 2003 | pmid = 15871554 | doi = 10.2165/00024677-200302010-00005 | s2cid = 209144694 }} It is also indicated for the treatment of moderate acne, premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), and dysmenorrhea (painful menstruation) in women. The medication is taken by mouth and contains 30 μg EE and 3 mg DRSP per tablet (brand names Yasmin, others) or 20 μg EE and 3 mg DRSP per tablet (brand names Yaz, Yasminelle, Nikki, others). A formulation with levomefolic acid (vitamin B₉) has also been marketed (brand names Beyaz, Safyral, others), with similar indications.{{Cite web |url= https://adisinsight.springer.com/drugs/800032716 |title=Ethinylestradiol/Drospirenone/Folic acid | work = AdisInsight | publisher = Springer Nature Switzerland AG }}{{cite web | title=Beyaz- drospirenone/ethinyl estradiol/levomefolate calcium and levomefolate calcium kit | website=DailyMed | date=19 May 2023 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8132454a-6135-4bac-b206-83a55eb8dbc6 | access-date=26 October 2024}} EE/DRSP is marketed widely throughout the world.{{Cite web |url= https://www.drugs.com/international/drospirenone.html |title = Drospirenone Uses, Side Effects & Warnings | work = Drugs.com }}

In 2022, it was the 142nd most commonly prescribed medication in the United States, with more than 4{{nbsp}}million prescriptions.{{cite web | title=The Top 300 of 2022 | url=https://clincalc.com/DrugStats/Top300Drugs.aspx | website=ClinCalc | access-date=30 August 2024 | archive-date=30 August 2024 | archive-url=https://web.archive.org/web/20240830202410/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status=live }}{{cite web | title = Drospirenone; Ethinyl Estradiol Drug Usage Statistics, United States, 2013 - 2022 | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/DrospirenoneEthinylEstradiol | access-date = 30 August 2024 }}