European Sleep Apnea Database

{{Infobox organization

| name = European Sleep Apnea Database

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| image = European Sleep Apnea Database.jpg

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| formation = 2006

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| type = Collaborative database

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| status = Active

| purpose = Compile information about sleep apnea

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| fields = Medicine, Internal medicine, Sleep medicine, Sleep apnea

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| key_people = Jan Hedner

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| affiliations = European Cooperation in Science and Technology
Sahlgrenska Academy at University of Gothenburg

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| website ={{Official website|http://esada.med.gu.se}}

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The European Sleep Apnea Database (ESADA) (also referred to with spelling European Sleep Apnoea Database and European Sleep Apnoea Cohort) is a collaboration between European sleep centres as part of the European Cooperation in Science and Technology (COST) Action B 26. The main contractor of the project is the Sahlgrenska Academy at University of Gothenburg, Institute of Medicine, Department of Internal Medicine, and the co-ordinator is Jan Hedner, MD, PhD, Professor of Sleep Medicine.Hedner 2011, pp. 635–642.

The book Clinical Genomics: Practical Applications for Adult Patient Care said ESADA was an example initiatives which afford an "excellent opportunity" for future collaborative research into genetic aspects of obstructive sleep apnea syndrome (OSAS). Both the European Respiratory Society and the European Sleep Research Society have noted the impact for research cooperative efforts of the database resource.

History

=2006 – 2010=

In 2006 the European Sleep Apnea Database (ESADA) began as an initiative between 27 European sleep study facilities to combine information and compile it into one shared resource.ESRS Newsletter 2013Grote 2014 It was formed as part of the European Cooperation in Science and Technology (COST) Action B 26.Obesity, Fitness & Wellness Week 2011, p. 3. In addition to financial help from COST, the initiative received assistance from companies Philips Respironics and ResMed.Grote May 2012, pp. 10–11. The database storing the association's resource information is located in Gothenburg, Sweden. The group's goal was twofold: to serve as a reference guide to those researching sleep disorders, and to compile information about how different caregivers treat patients with sleep apnea.

5,103 patients were tracked from March 2007 to August 2009. Data collected on these patients included symptoms experienced, medication, medical history, and sleep data, all inputted into an online format for further analysis. Database researchers reported on their methodology and results in 2010 to the American Thoracic Society, on their observed findings regarding percentages of metabolic and cardiovascular changes related to patients with obstructive sleep apnea.Hedner 2010 The 2010 research resulted from collaboration between 22 study centres across 16 countries in Europe involving 27 researchers. The primary participants who presented to the American Thoracic Society included researchers from: Sahlgrenska University Hospital, Gothenburg, Sweden; Technion – Israel Institute of Technology, Haifa, Israel; National TB & Lung Diseases Research Institute, Warsaw, Poland; CNR Institute of Biomedicine and Molecular, Palermo, Italy; Instituto Auxologico Italiano, Ospedale San Luca, Milan, Italy; and St. Vincent University Hospital, Dublin, Ireland. Their analysis was published in 2010 in the American Journal of Respiratory and Critical Care Medicine.

=2011 – present=

In 2011 there were 22 sleep disorder centres in Europe involved in the collaboration. The group published research in 2011 analyzing the percentage of patients with sleep apnea that have obesity. By 2012 the database maintained information on over 12,500 patients in Europe; it also contained DNA samples of 2,600 individuals. ESADA was represented in 2012 at the 21st annual meeting of the European Sleep Research Society in Paris, France, and was one of four European Sleep Research Networks that held a session at the event.ESRS Newsletter 2012, p. 8. Pierre Escourrou and Fadia Jilwan wrote a 2012 article for the European Respiratory Journal after studying data from ESADA involving 8,228 total patients from 23 different facilities. They analyzed whether polysomnography was a good measure for hypopnea and sleep apnea.Escourrou 2012 Researchers from the department of pulmonary diseases at Turku University Hospital in Turku, Finland compared variations between sleep centres in the ESADA database and published their findings in the European Respiratory Journal.Saaresranta 2012 They looked at the traits of 5,103 patients from 22 centres. They reported on the average age of patients in the database, and the prevalence by region of performing sleep study with cardiorespiratory polygraphy.

The database added a centre in Hamburg, Germany in 2013 managed by physician Holger Hein. The group's annual meeting in 2013 was held in Edinburgh, United Kingdom and was run by Renata Riha. By March 2013, there were approximately 13,000 total patients being studied in the program, with about 200 additional patients being added into the database each month. Analysis published by researchers from Italy and Sweden in September 2013 in the European Respiratory Journal analyzed if there was a correlation between renal function problems and obstructive sleep apnea.Marrone 2013 They analyzed data from 17 countries in Europe representing 24 sleep centres and 8,112 total patients. They tested whether patients of different types of demographics with other existing health problems had a change in probability of kidney function problems, if they concurrently had obstructive sleep apnea.

In 2014, researchers released data studying 5,294 patients from the database compared prevalence of sleep apnea with increased blood sugar.Healthcare Purchasing News 2014, p. 16. Their results were published in the European Respiratory Journal.Right Vision News 2014Daily The Pak Banker 2014 They studied glycated hemoglobin levels in the patients and compared them with measured severity in sleep apnea.The Huffington Post 2014 The researchers analyzed glycated hemoglobin levels among a class of individuals with less severe sleep apnea and those with a higher determined amount of sleep apnea problems. As of 20 March 2014 the database included information on a total of 15,956 patients. A 2014 article in the European Respiratory Journal drawing from the ESADA analyzed whether lack of adequate oxygen during a night's sleep was an indicator for high blood pressure.Tkacova 2014, pp. 931–941

Reception

In the 2013 book Clinical Genomics: Practical Applications for Adult Patient Care, ESADA is said to be an example of the kind of initiative which affords an "excellent opportunity" for future collaborative research into genetic aspects of obstructive sleep apnea syndrome (OSAS).Murray 2013, p. 586. Both the European Respiratory Society and the European Sleep Research Society have noted the impact for research cooperative efforts of the database resource.

Notes

References

{{cite news|work=Daily The Pak Banker|date=5 April 2014|title=Sleep apnoea could lead to elevated blood sugar levels|via=LexisNexis|location=Islamabad}}
{{cite journal|journal=European Respiratory Journal|publisher=European Respiratory Society|title=The method for diagnosis matters in sleep apnea. A systematic analysis of polygraphy and polysomnography data in the European Sleep Apnea Database (ESADA)|date=1 September 2012|first=Pierre|last=Escourrou|author2=Fadia Jilwan|url=http://erj.ersjournals.com/content/40/Suppl_56/184.short|accessdate=23 October 2014|volume=40|issue=Suppl 56 184|issn=0903-1936|archivedate=23 October 2014|archiveurl=https://web.archive.org/web/20141023203141/http://erj.ersjournals.com/content/40/Suppl_56/184.short}}
{{cite journal|journal=ESRS Newsletter|date=October 2012|publisher=European Sleep Research Society|title=ESRS 2012 Meeting in Paris|url=http://www.esrs.eu/uploads/tx_templavoila/ESRS_Newsletter_October_2012.pdf|accessdate=22 October 2014|archiveurl=https://web.archive.org/web/20141022000341/http://www.esrs.eu/uploads/tx_templavoila/ESRS_Newsletter_October_2012.pdf|archivedate=22 October 2014}}
{{cite journal|journal=ESRS Newsletter|date=March 2013|publisher=European Sleep Research Society|title=Sleep Apnea Network / European Sleep Apnea Database (ESADA) – A Brief Summary|url=http://www.esrs.eu/committees-networks/sleep-apnea-network-european-sleep-apnea-data-base-esada/reports/march-2013.html|accessdate=21 October 2014|archiveurl=https://web.archive.org/web/20131129015523/http://www.esrs.eu/committees-networks/sleep-apnea-network-european-sleep-apnea-data-base-esada/reports/march-2013.html|archivedate=29 November 2013}}
{{cite journal|title=Sleep apnea linked with blood sugar levels|journal=Healthcare Purchasing News|date=May 2014|volume=38|issue=5|page=16|via=InfoTrac}}
{{cite journal|last=Hedner |first=Jan|author2=Ludger Grote |author3=Peretz Lavie |author4=Pawel Sliwinski |author5=Marisa Bonsignore |author6=Gianfranco Parati |author7=Walter T. McNicholas |title=The European Sleep Apnea Database (ESADA) – Design And First Interim Crossectional Description Of Results From 22 European Sleep Laboratories|doi=10.1164/ajrccm-conference.2010.181.1_MeetingAbstracts.A6857 |journal=American Journal of Respiratory and Critical Care Medicine|volume=181|page=A6857|publisher=American Thoracic Society|date=2010|url=http://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2010.181.1_MeetingAbstracts.A6857|accessdate=23 October 2014|url-access=subscription}}
{{cite journal|last=Hedner |first=Jan|url=http://erj.ersjournals.com/content/38/3/635.abstract|title=The European Sleep Apnoea Database (ESADA): report from 22 European sleep laboratories|journal=European Respiratory Journal|date=26 May 2011|doi=10.1183/09031936.00046710|pmid=21622583|volume=38|issue=3|pages=635–642|publisher=European Respiratory Society|issn=0903-1936|doi-access=free}}
{{cite news|first=Ludger|last=Grote|title=Sleep Apnea Network / European Sleep Apnea Database (ESADA) – An Update|date=May 2012|publisher=European Sleep Research Society|work=ESRS Newsletter|pages=10–11|url=http://www.esrs.eu/uploads/tx_templavoila/ESRS_Newsletter_May_2012.pdf|accessdate=21 October 2014|archiveurl=https://web.archive.org/web/20141021235023/http://www.esrs.eu/uploads/tx_templavoila/ESRS_Newsletter_May_2012.pdf|archivedate=21 October 2014}}
{{cite news|first=Ludger|last=Grote|url=http://www.esrs.eu/committees-networks/sleep-apnea-network-european-sleep-apnea-data-base-esada/reports/march-2014.html|accessdate=21 October 2014|date=March 2014|title=The European Sleep Apnea Database (ESADA) – a progress report for the ESRS newsletter|work=ESRS Newsletter|publisher=European Sleep Research Society|archivedate=21 October 2014|archiveurl=https://web.archive.org/web/20141021160234/http://www.esrs.eu/committees-networks/sleep-apnea-network-european-sleep-apnea-data-base-esada/reports/march-2014.html}}
{{cite news|url=http://www.huffingtonpost.com/2014/04/07/blood-sugar-sleep-apnea_n_5084131.html|title=New Study Links Blood Sugar Levels With Sleep Apnea|date= 7 April 2014|accessdate=21 October 2014|archivedate=21 October 2014|archiveurl=https://web.archive.org/web/20141021164041/http://www.huffingtonpost.com/2014/04/07/blood-sugar-sleep-apnea_n_5084131.html|work=The Huffington Post}}
{{cite journal|journal=European Respiratory Journal|publisher=European Respiratory Society|issn=0903-1936|title=Relationship between mild to moderate renal dysfunction and obstructive sleep apnea: Data from the European sleep apnea database|url=http://erj.ersjournals.com/content/42/Suppl_57/P4037.short|accessdate=23 October 2014|archivedate=23 October 2014|archiveurl=https://web.archive.org/web/20141023211429/http://erj.ersjournals.com/content/42/Suppl_57/P4037.short|date=1 September 2013|volume=42|issue=Suppl 57 P4037|first=Oreste |last=Marrone|author2=Salvatore Battaglia |author3=Maria Rosaria Bonsignore }}
{{Cite book|first=Michael|last= Murray|author2=Monica Giovanni |author3=Mark W. Babyatsky |title=Clinical Genomics: Practical Applications for Adult Patient Care|page=586|year=2013|publisher=McGraw-Hill Professional|isbn=978-0071622448}}
{{cite journal|title=Data from J. Hedner et al Provide New Insights into Cardiovascular Research|journal=Obesity, Fitness & Wellness Week|date= 8 October 2011|page=3|publisher= NewsRX LLC|via=InfoTrac|issn=1531-6386}}
{{cite news|work=Right Vision News|date=6 April 2014|title=Pakistan: Sleep apnoea could lead to elevated blood sugar levels|location=Islamabad|via=LexisNexis}}
{{cite journal|first=Ruzena|last= Tkacova|author2=Walter T. McNichola |author3=Martin Javorsky |author4=Ingo Fietze |author5=Pawel Sliwinski |author6=Gianfranco Parati |author7=Ludger Grote |author8=Jan Hedner |title=Nocturnal intermittent hypoxia predicts prevalent hypertension in the European Sleep Apnoea Database cohort study|url=http://erj.ersjournals.com/content/44/4/931.short|doi=10.1183/09031936.00225113|date=1 October 2014|volume=44|issue=4|pages=931–941|journal=European Respiratory Journal|publisher=European Respiratory Society|pmid= 25102963|issn=0903-1936|doi-access=free|url-access=subscription}}
{{cite journal|journal=European Respiratory Journal|publisher=European Respiratory Society|issn=0903-1936|title=Regional differences in characteristics of patients referred to European sleep centers. Results from the European Sleep Apnea Database (ESADA)|url=http://erj.ersjournals.com/content/40/Suppl_56/4316.short|accessdate=23 October 2014|date=1 September 2012|volume=40|issue= Suppl 56 4316|first=Tarja |last=Saaresranta |author2=Marisa Bonsignore |author3=Ludger Grote |author4=Jan Hedner |author5=Walter McNicholas |author6=Josep Montserrat |author7=Thomas Penzel |author8=Martin Pretl |author9=Renata Riha |author10=Pawel Sliwinski |author11=Jan Zielinski}}