FCER1

FcεRI is found on epidermal Langerhans cells, eosinophils, mast cells, and basophils.{{cite journal |vauthors=Ochiai K, Wang B, Rieger A, Kilgus O, Maurer D, Födinger D, Kinet J, Stingl G, Tomioka H |title=A review on Fc epsilon RI on human epidermal Langerhans cells |series=104 |journal=International Archives of Allergy and Immunology |volume=Suppl 1 |issue=1 |pages=63–64 |year=1994 |pmid=8156009 |doi=10.1159/000236756}}{{cite journal |vauthors=Prussin C, Metcalfe D |title=5 |journal=Nature |year=1994 |volume=367 |issue=6459 |pages=183–6 |pmid=8114916 |doi=10.1038/367183a0|s2cid=4331405 }}{{cite journal |last1=Gounni |first1=A. |last2=Lamkhioued |first2=B. |last3=Ochiai |first3=K. |last4=Tanaka |first4=Y. |last5=Delaporte |first5=E. |last6=Capron |first6=A. |last7=Kinet |first7=J.P. |last8=Capron |first8=M. |title=IgE, mast cells, basophils, and eosinophils |journal=Journal of Allergy and Clinical Immunology |volume=117 |issue=2 Suppl Mini–Primer |pages=S450–5456 |year=2006 |pmid=16455345 |doi=10.1016/j.jaci.2005.11.016}} As a result of its cellular distribution, this receptor plays a major role in controlling allergic responses. FcεRI is also expressed on antigen-presenting cells, and controls the production of important immune mediators (cytokines, interleukins, leukotrienes, and prostaglandins) that promote inflammation.{{cite journal |vauthors=von Bubnoff D, Novak N, Kraft S, Bieber T |title=The central role of FcepsilonRI in allergy |journal=Clinical and Experimental Dermatology |volume=28 |issue=2 |pages=184–187 |year=2003 |pmid=12653710 |doi=10.1046/j.1365-2230.2003.01209.x|s2cid=2080598 }} The most known mediator is histamine, which results in the five symptoms of inflammation: heat, swelling, pain, redness and loss of function.

FcεRI was demonstrated in bronchial/tracheal airway smooth muscle cells in normal and asthmatic patients. FcεRI cross-linking by IgE and anti-IgE antibodies led to Th2 (IL-4, -5, and -13) cytokines and CCL11/eotaxin-1 chemokine release; and ([Ca2+]i) mobilization, suggesting a likely IgE-FcεRI-ASM (airway smooth muscle cell)-mediated link to airway inflammation and airway hyperresponsiveness.{{cite journal|last1=Gounni|first1=A.S.|last2=Wellemans|first2=V.|last3=Yang|first3=J.|last4=Bellesort|first4=F.|last5=Kassiri|first5=K.|last6=Gangloff|first6=S.|last7=Guenounou|first7=M.|last8=Halayko|first8=A.J.|last9=Hamid|first9=Q.|last10=Lamkhioued|first10=B.|authorlink8=Andrew Halayko|title=Human airway smooth muscle cells express the high affinity receptor for IgE (Fc epsilon RI): a critical role of Fc epsilon RI in human airway smooth muscle cell function|url=https://www.jimmunol.org/content/175/4/2613|journal=Journal of Immunology|volume=175|issue=4|pages=2613–2621|date=August 15, 2005|pmid=16081836|doi=10.4049/jimmunol.175.4.2613|doi-access=free}}{{cite journal|last=Gounni|first=A.S.|title=The high-affinity IgE receptor (FcepsilonRI): a critical regulator of airway smooth muscle cells?|url=https://journals.physiology.org/doi/full/10.1152/ajplung.00005.2006|journal=American Journal of Physiology| date=September 2006|volume=291|issue=3|pages=L312-321|pmid=16581830|doi=10.1152/ajplung.00005.2006}}

Crosslinking of the FcεRI via IgE-antigen complexes leads to degranulation of mast cells or basophils and release of inflammatory mediators.{{cite journal | author = Siraganian RP | title = Mast cell signal transduction from the high-affinity IgE receptor | journal = Current Opinion in Immunology | volume = 15 | issue = 6 | pages = 639–646 |date=December 2003 | pmid = 14630197 | doi = 10.1016/j.coi.2003.09.010 | s2cid = 39294873 | url = https://zenodo.org/record/1258843}} Under laboratory conditions, degranulation of isolated basophils can also be induced with antibodies to the FcεRIα, which crosslink the receptor. Such crosslinking and potentially pathogenic autoantibodies to the FcεRIα have been isolated from human cord blood, which suggest that they occur naturally and are present already at birth. However, their epitope on FcεRIα was masked by IgE, and the affinity of the corresponding autoantibodies found in healthy adults appeared lowered.{{cite journal |vauthors=Bobrzynski T, Fux M, Vogel M, Stadler MB, Stadler BM, Miescher SM | title = A high-affinity natural autoantibody from human cord blood defines a physiologically relevant epitope on the FcepsilonRIalpha | journal = Journal of Immunology | volume = 175 | issue = 10 | pages = 6589–6596 |date=November 2005 | pmid = 16272313 | doi = 10.4049/jimmunol.175.10.6589| doi-access = free }}

• Omalizumab

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• {{MeshName|Fc+epsilon+RI}}

{{Immune receptors}}

{{DEFAULTSORT:Fceri}}

Category:Fc receptors

Category:Proteins