FCGR2A

{{Short description|Mammalian protein found in Homo sapiens}}

{{Infobox_gene}}

Low affinity immunoglobulin gamma Fc region receptor II-a is a protein that in humans is encoded by the FCGR2A gene.{{cite journal | vauthors = Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV | title = Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination | journal = Science | volume = 248 | issue = 4956 | pages = 732–5 | date=June 1990| pmid = 2139735 | doi =10.1126/science.2139735 | bibcode =1990Sci...248..732Q}}{{cite web | title = Entrez Gene: FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2212}}

Interactions

FCGR2A has been shown to interact with PIK3R1{{cite journal |last=Chacko |first=G W |author2=Brandt J T |author3=Coggeshall K M |author4=Anderson C L |date=May 1996|title=Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides |journal=J. Biol. Chem. |volume=271 |issue=18 |pages=10775–81 | issn = 0021-9258| pmid = 8631888 |doi=10.1074/jbc.271.18.10775 |doi-access=free }}{{cite journal |last=Ibarrola |first=I |author2=Vossebeld P J |author3=Homburg C H |author4=Thelen M |author5=Roos D |author6=Verhoeven A J |date=July 1997|title=Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa |journal=Biochim. Biophys. Acta |volume=1357 |issue=3 |pages=348–58 | issn = 0006-3002| pmid = 9268059 | doi=10.1016/S0167-4889(97)00034-7|doi-access= }} and Syk.{{cite journal |last=Kim |first=M K |author2=Pan X Q |author3=Huang Z Y |author4=Hunter S |author5=Hwang P H |author6=Indik Z K |author7=Schreiber A D |date=January 2001|title=Fc gamma receptors differ in their structural requirements for interaction with the tyrosine kinase Syk in the initial steps of signaling for phagocytosis |journal=Clin. Immunol. |volume=98 |issue=1 |pages=125–32 | issn = 1521-6616| pmid = 11141335 |doi = 10.1006/clim.2000.4955 }}

See also

References

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Further reading

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  • {{cite journal | author=McKenzie SE |title=Humanized mouse models of FcR clearance in immune platelet disorders. |journal=Blood Rev. |volume=16 |issue= 1 |pages= 3–5 |year= 2002 |pmid= 11913983 |doi= 10.1054/blre.2001.0170 }}
  • {{cite journal | vauthors=Ernst LK, van de Winkel JG, Chiu IM, Anderson CL |title=Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products. |journal=J. Biol. Chem. |volume=267 |issue= 22 |pages= 15692–700 |year= 1992 |doi=10.1016/S0021-9258(19)49591-4 |pmid= 1379234 |doi-access=free }}
  • {{cite journal | author=Seki T |title=Identification of multiple isoforms of the low-affinity human IgG Fc receptor. |journal=Immunogenetics |volume=30 |issue= 1 |pages= 5–12 |year= 1989 |pmid= 2526077 |doi=10.1007/BF02421463 |s2cid=23208039 }}
  • {{cite journal | vauthors=Hessian PA, Highton J, Palmer DG |title=Quantification of macrophage cell surface molecules in rheumatoid arthritis |journal=Clin. Exp. Immunol. |volume=77 |issue= 1 |pages= 47–51 |year= 1989 |pmid= 2527651 | pmc=1541930 }}
  • {{cite journal | vauthors=Brooks DG, Qiu WQ, Luster AD, Ravetch JV |title=Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes |journal=J. Exp. Med. |volume=170 |issue= 4 |pages= 1369–85 |year= 1989 |pmid= 2529342 |doi=10.1084/jem.170.4.1369 | pmc=2189488 }}
  • {{cite journal | vauthors=Lanier LL, Cwirla S, Yu G |title=Membrane anchoring of a human IgG Fc receptor (CD16) determined by a single amino acid |journal=Science |volume=246 |issue= 4937 |pages= 1611–3 |year= 1990 |pmid= 2531919 |doi=10.1126/science.2531919 |display-authors=etal|bibcode=1989Sci...246.1611L }}
  • {{cite journal | vauthors=Stuart SG, Trounstine ML, Vaux DJ |title=Isolation and expression of cDNA clones encoding a human receptor for IgG (Fc gamma RII) |journal=J. Exp. Med. |volume=166 |issue= 6 |pages= 1668–84 |year= 1987 |pmid= 2824655 |doi=10.1084/jem.166.6.1668 | pmc=2188792 |display-authors=etal}}
  • {{cite journal | vauthors=Hibbs ML, Bonadonna L, Scott BM |title=Molecular cloning of a human immunoglobulin G Fc receptor |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 7 |pages= 2240–4 |year= 1988 |pmid= 2965389 |doi=10.1073/pnas.85.7.2240 | pmc=279966 |display-authors=etal|bibcode=1988PNAS...85.2240H|doi-access=free }}
  • {{cite journal | vauthors=Huizinga TW, van der Schoot CE, Jost C |title=The PI-linked receptor FcRIII is released on stimulation of neutrophils |journal=Nature |volume=333 |issue= 6174 |pages= 667–9 |year= 1988 |pmid= 2967437 |doi= 10.1038/333667a0 |display-authors=etal|bibcode=1988Natur.333..667H |s2cid=4342856 }}
  • {{cite journal | vauthors=Sammartino L, Webber LM, Hogarth PM |title=Assignment of the gene coding for human FcRII (CD32) to bands q23q24 on chromosome 1 |journal=Immunogenetics |volume=28 |issue= 5 |pages= 380–1 |year= 1988 |pmid= 2971615 |doi=10.1007/BF00364238 |s2cid=35705081 |display-authors=etal}}
  • {{cite journal | vauthors=Stengelin S, Stamenkovic I, Seed B |title=Isolation of cDNAs for two distinct human Fc receptors by ligand affinity cloning |journal=EMBO J. |volume=7 |issue= 4 |pages= 1053–9 |year= 1988 |pmid= 3402431 |doi= 10.1002/j.1460-2075.1988.tb02913.x| pmc=454434 }}
  • {{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
  • {{cite journal | vauthors=Chacko GW, Brandt JT, Coggeshall KM, Anderson CL |title=Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides |journal=J. Biol. Chem. |volume=271 |issue= 18 |pages= 10775–81 |year= 1996 |pmid= 8631888 |doi=10.1074/jbc.271.18.10775 |doi-access=free }}
  • {{cite journal | vauthors=Salmon JE, Millard S, Schachter LA |title=Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans |journal=J. Clin. Invest. |volume=97 |issue= 5 |pages= 1348–54 |year= 1996 |pmid= 8636449 |doi=10.1172/JCI118552 | pmc=507190 |display-authors=etal}}
  • {{cite journal | vauthors=Bewarder N, Weinrich V, Budde P |title=In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation |journal=Mol. Cell. Biol. |volume=16 |issue= 9 |pages= 4735–43 |year= 1996 |pmid= 8756631 |doi= 10.1128/MCB.16.9.4735| pmc=231474 |display-authors=etal}}
  • {{cite journal | vauthors=Sármay G, Koncz G, Gergely J |title=Human type II Fcgamma receptors inhibit B cell activation by interacting with the p21(ras)-dependent pathway |journal=J. Biol. Chem. |volume=271 |issue= 48 |pages= 30499–504 |year= 1997 |pmid= 8940017 |doi=10.1074/jbc.271.48.30499 |doi-access=free |hdl=2437/195888 |hdl-access=free }}
  • {{cite journal | vauthors=Ibarrola I, Vossebeld PJ, Homburg CH |title=Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa |journal=Biochim. Biophys. Acta |volume=1357 |issue= 3 |pages= 348–58 |year= 1997 |pmid= 9268059 |doi=10.1016/S0167-4889(97)00034-7 |display-authors=etal|doi-access= }}
  • {{cite journal | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
  • {{cite journal | vauthors=De SK, Venkateshan CN, Seth P |title=Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines |journal=Blood |volume=91 |issue= 6 |pages= 2108–17 |year= 1998 |pmid= 9490697 |doi= 10.1182/blood.V91.6.2108|display-authors=etal|doi-access=free }}

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