FMNL1
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Formin-like protein 1 is a protein that in humans is encoded by the FMNL1 gene.{{cite journal |vauthors=Aronsson FC, Magnusson P, Andersson B, Karsten SL, Shibasaki Y, Lendon CL, Goate AM, Brookes AJ | title = The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17 | journal = Hum Genet | volume = 103 | issue = 3 | pages = 340–345 |date=November 1998 | pmid = 9799091 | doi =10.1007/s004390050827 | s2cid = 11305597 }}{{cite web | title = Entrez Gene: FMNL1 formin-like 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=752}}
This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been determined.
Interactions
FMNL1 has been shown to interact with Profilin 1,{{cite journal |last=Yayoshi-Yamamoto |first=S |author2=Taniuchi I |author3=Watanabe T |date=September 2000 |title=FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages |journal=Mol. Cell. Biol. |volume=20 |issue=18 |pages=6872–6881 |location = UNITED STATES| issn = 0270-7306| pmid = 10958683 |doi=10.1128/MCB.20.18.6872-6881.2000 |pmc=86228 }} PFN2 and RAC1.
See also
References
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Further reading
{{refbegin | 2}}
- {{cite journal |vauthors=Kennerson ML, Nassif NT, Nicholson GA |title=Genomic structure and physical mapping of C17orf1: a gene associated with the proximal element of the CMT1A-REP binary repeat |journal=Genomics |volume=53 |issue= 1 |pages= 110–112 |year= 1998 |pmid= 9787083 |doi= 10.1006/geno.1998.5453 }}
- {{cite journal |vauthors=Yayoshi-Yamamoto S, Taniuchi I, Watanabe T |title=FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages |journal=Mol. Cell. Biol. |volume=20 |issue= 18 |pages= 6872–6881 |year= 2000 |pmid= 10958683 |doi=10.1128/MCB.20.18.6872-6881.2000 | pmc=86228 }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M|doi-access=free }}
- {{cite journal |vauthors=Katoh M, Katoh M |title=Identification and characterization of human DAAM2 gene in silico |journal=Int. J. Oncol. |volume=22 |issue= 4 |pages= 915–20 |year= 2003 |pmid= 12632087 |doi= 10.3892/ijo.22.4.915}}
- {{cite journal |vauthors=Katoh M, Katoh M |title=Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico |journal=Int. J. Oncol. |volume=22 |issue= 5 |pages= 1161–8 |year= 2003 |pmid= 12684686 |doi= 10.3892/ijo.22.5.1161}}
- {{cite journal | author=Favaro PM |title=Human leukocyte formin: a novel protein expressed in lymphoid malignancies and associated with Akt |journal=Biochem. Biophys. Res. Commun. |volume=311 |issue= 2 |pages= 365–371 |year= 2004 |pmid= 14592423 |doi=10.1016/j.bbrc.2003.10.012 |name-list-style=vanc| author2=de Souza Medina S | author3=Traina F | display-authors=3 | last4=Sanchez Bassères | first4=Daniela | last5=Ferreira Costa | first5=Fernando | last6=Teresinha Olalla Saad | first6=Sara }}
- {{cite journal | author=Colland F |title=Functional proteomics mapping of a human signaling pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–1332 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 |name-list-style=vanc| author2=Jacq X | author3=Trouplin V | display-authors=3 | last4=Mougin | first4=C | last5=Groizeleau | first5=C | last6=Hamburger | first6=A | last7=Meil | first7=A | last8=Wojcik | first8=J | last9=Legrain | first9=P }}
- {{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
- {{cite journal | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–1178 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-style=vanc| author2=Venkatesan K | author3=Hao T | display-authors=3 | last4=Hirozane-Kishikawa | first4=Tomoko | last5=Dricot | first5=Amélie | last6=Li | first6=Ning | last7=Berriz | first7=Gabriel F. | last8=Gibbons | first8=Francis D. | last9=Dreze | first9=Matija |bibcode=2005Natur.437.1173R|s2cid=4427026 }}
- {{cite journal | author=Olsen JV |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–648 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |name-list-style=vanc| author2=Blagoev B | author3=Gnad F | display-authors=3 | last4=Macek | first4=Boris | last5=Kumar | first5=Chanchal | last6=Mortensen | first6=Peter | last7=Mann | first7=Matthias |s2cid=7827573 | doi-access=free}}
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