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PFN2

{{Short description|Protein-coding gene in the species Homo sapiens}}

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{{Infobox_gene}}

Profilin-2 is a protein that in humans is encoded by the PFN2 gene.{{cite journal |vauthors=Joensuu T, Blanco G, Pakarinen L, Sistonen P, Kaariainen H, Brown S, Chapelle A, Sankila EM | title = Refined mapping of the Usher syndrome type III locus on chromosome 3, exclusion of candidate genes, and identification of the putative mouse homologous region | journal = Genomics | volume = 38 | issue = 3 | pages = 255–63 |date=March 1997 | pmid = 8975700 | doi =10.1006/geno.1996.0626 }}{{cite journal |vauthors=Honore B, Madsen P, Andersen AH, Leffers H | title = Cloning and expression of a novel human profilin variant, profilin II | journal = FEBS Lett | volume = 330 | issue = 2 | pages = 151–5 |date=October 1993 | pmid = 8365484 | doi =10.1016/0014-5793(93)80262-S | s2cid = 46347046 | doi-access = free }}{{cite web | title = Entrez Gene: PFN2 profilin 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5217}}

The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene.

Interactions

PFN2 has been shown to interact with ROCK1,{{cite journal |last=Da Silva |first=Jorge Santos |author2=Medina Miguel |author3=Zuliani Cecilia |author4=Di Nardo Alessia |author5=Witke Walter |author6=Dotti Carlos G |date=September 2003 |title=RhoA/ROCK regulation of neuritogenesis via profilin IIa–mediated control of actin stability |journal=J. Cell Biol. |volume=162 |issue=7 |pages=1267–79 |location = United States| issn = 0021-9525| pmid = 14517206 |doi = 10.1083/jcb.200304021 |pmc=2173969 }} Vasodilator-stimulated phosphoprotein,{{cite journal |last=Reinhard |first=M |author2=Giehl K |author3=Abel K |author4=Haffner C |author5=Jarchau T |author6=Hoppe V |author7=Jockusch B M |author8=Walter U |date=April 1995 |title=The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins |journal=EMBO J. |volume=14 |issue=8 |pages=1583–9 |location = ENGLAND| issn = 0261-4189| pmid = 7737110 |pmc=398250 |doi=10.1002/j.1460-2075.1995.tb07146.x}}{{cite journal |last=Harbeck |first=B |author2=Hüttelmaier S |author3=Schluter K |author4=Jockusch B M |author5=Illenberger S |date=October 2000 |title=Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin |journal=J. Biol. Chem. |volume=275 |issue=40 |pages=30817–25 |location = UNITED STATES| issn = 0021-9258| pmid = 10882740 |doi = 10.1074/jbc.M005066200 |doi-access=free }} CCDC113{{cite web|title=Coiled-Coil Domain Containing 113 |url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=CCDC113&search=ccdc113|publisher=GeneCards|access-date=May 8, 2013}} and FMNL1.{{cite journal |last=Yayoshi-Yamamoto |first=S |author2=Taniuchi I |author3=Watanabe T |date=September 2000 |title=FRL, a Novel Formin-Related Protein, Binds to Rac and Regulates Cell Motility and Survival of Macrophages |journal=Mol. Cell. Biol. |volume=20 |issue=18 |pages=6872–81 |location = UNITED STATES| issn = 0270-7306| pmid = 10958683 |doi=10.1128/MCB.20.18.6872-6881.2000 |pmc=86228 }}

References

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Further reading

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  • {{cite journal |vauthors=Qualmann B, Kessels MM |title=Endocytosis and the cytoskeleton |journal=Int. Rev. Cytol. |volume=220 |pages= 93–144 |year= 2003 |pmid= 12224553 |doi=10.1016/S0074-7696(02)20004-2 | series=International Review of Cytology | isbn=978-0-12-364624-8 }}
  • {{cite journal |vauthors=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin |journal=J. Infect. |volume=24 |issue= 3 |pages= 317–20 |year= 1992 |pmid= 1602151 |doi=10.1016/S0163-4453(05)80037-4 }}
  • {{cite journal |vauthors=Kwiatkowski DJ, Bruns GA |title=Human profilin. Molecular cloning, sequence comparison, and chromosomal analysis |journal=J. Biol. Chem. |volume=263 |issue= 12 |pages= 5910–5 |year= 1988 |doi=10.1016/S0021-9258(18)60651-9 |pmid= 3356709 |doi-access=free }}
  • {{cite journal |vauthors=Reinhard M, Giehl K, Abel K, etal |title=The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins |journal=EMBO J. |volume=14 |issue= 8 |pages= 1583–9 |year= 1995 |pmid= 7737110 |doi= 10.1002/j.1460-2075.1995.tb07146.x| pmc=398250 }}
  • {{cite journal |vauthors=Gieselmann R, Kwiatkowski DJ, Janmey PA, Witke W |title=Distinct biochemical characteristics of the two human profilin isoforms |journal=Eur. J. Biochem. |volume=229 |issue= 3 |pages= 621–8 |year= 1995 |pmid= 7758455 |doi=10.1111/j.1432-1033.1995.tb20506.x }}
  • {{cite journal |vauthors=Naylor SL, Carritt B, Boileau C, etal |title=Report of the sixth international workshop on human chromosome 3 mapping 1995 |journal=Cytogenet. Cell Genet. |volume=72 |issue= 4 |pages= 255–70 |year= 1996 |pmid= 8641130 |doi=10.1159/000134204 }}
  • {{cite journal |vauthors=Witke W, Podtelejnikov AV, Di Nardo A, etal |title=In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly |journal=EMBO J. |volume=17 |issue= 4 |pages= 967–76 |year= 1998 |pmid= 9463375 |doi= 10.1093/emboj/17.4.967 | pmc=1170446 }}
  • {{cite journal |vauthors=Nodelman IM, Bowman GD, Lindberg U, Schutt CE |title=X-ray structure determination of human profilin II: A comparative structural analysis of human profilins |journal=J. Mol. Biol. |volume=294 |issue= 5 |pages= 1271–85 |year= 2000 |pmid= 10600384 |doi= 10.1006/jmbi.1999.3318 }}
  • {{cite journal |vauthors=Harbeck B, Hüttelmaier S, Schluter K, etal |title=Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin |journal=J. Biol. Chem. |volume=275 |issue= 40 |pages= 30817–25 |year= 2000 |pmid= 10882740 |doi= 10.1074/jbc.M005066200 |doi-access= free }}
  • {{cite journal |vauthors=Lambrechts A, Kwiatkowski AV, Lanier LM, etal |title=cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains |journal=J. Biol. Chem. |volume=275 |issue= 46 |pages= 36143–51 |year= 2000 |pmid= 10945997 |doi= 10.1074/jbc.M006274200 |doi-access= free }}
  • {{cite journal |vauthors=Lambrechts A, Braun A, Jonckheere V, etal |title=Profilin II Is Alternatively Spliced, Resulting in Profilin Isoforms That Are Differentially Expressed and Have Distinct Biochemical Properties |journal=Mol. Cell. Biol. |volume=20 |issue= 21 |pages= 8209–19 |year= 2000 |pmid= 11027290 |doi=10.1128/MCB.20.21.8209-8219.2000 | pmc=86430 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Tojo H, Kaieda I, Hattori H, etal |title=The Formin family protein, formin homolog overexpressed in spleen, interacts with the insulin-responsive aminopeptidase and profilin IIa |journal=Mol. Endocrinol. |volume=17 |issue= 7 |pages= 1216–29 |year= 2004 |pmid= 12677009 |doi= 10.1210/me.2003-0056 |doi-access= }}
  • {{cite journal |vauthors=Da Silva JS, Medina M, Zuliani C, etal |title=RhoA/ROCK regulation of neuritogenesis via profilin IIa–mediated control of actin stability |journal=J. Cell Biol. |volume=162 |issue= 7 |pages= 1267–79 |year= 2003 |pmid= 14517206 |doi= 10.1083/jcb.200304021 | pmc=2173969 }}
  • {{cite journal |vauthors=Goehler H, Lalowski M, Stelzl U, etal |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853–65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016 |doi-access= free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Lederer M, Jockusch BM, Rothkegel M |title=Profilin regulates the activity of p42POP, a novel Myb-related transcription factor |journal=J. Cell Sci. |volume=118 |issue= Pt 2 |pages= 331–41 |year= 2005 |pmid= 15615774 |doi= 10.1242/jcs.01618 |s2cid=14624003 |doi-access= }}

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External links

  • {{PDBe-KB2|P35080|Human Profilin-2}}
  • {{PDBe-KB2|Q9JJV2|Mouse Profilin-2}}

{{PDB Gallery|geneid=5217}}

{{Cytoskeletal Proteins}}

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