FNBP1

The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human.{{cite web | title = Entrez Gene: FNBP1 formin binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23048}}

FNBP1 has been shown to interact with:

• AKAP9,{{cite journal | vauthors = Larocca MC, Shanks RA, Tian L, Nelson DL, Stewart DM, Goldenring JR | title = AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus | journal = Mol. Biol. Cell | volume = 15 | issue = 6 | pages = 2771–81 | date = Jun 2004 | pmid = 15047863 | pmc = 420101 | doi = 10.1091/mbc.E03-10-0757 }}
• DNM1,{{cite journal | vauthors = Kamioka Y, Fukuhara S, Sawa H, Nagashima K, Masuda M, Matsuda M, Mochizuki N | title = A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis | journal = J. Biol. Chem. | volume = 279 | issue = 38 | pages = 40091–9 | date = Sep 2004 | pmid = 15252009 | doi = 10.1074/jbc.M404899200 | doi-access = free }}
• Fas ligand{{cite journal | vauthors = Ghadimi MP, Sanzenbacher R, Thiede B, Wenzel J, Jing Q, Plomann M, Borkhardt A, Kabelitz D, Janssen O | title = Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178) | journal = FEBS Lett. | volume = 519 | issue = 1–3 | pages = 50–8 | date = May 2002 | pmid = 12023017 | doi = 10.1016/s0014-5793(02)02709-6| s2cid = 26765451 }}
• SNX2,{{cite journal | vauthors = Fuchs U, Rehkamp GF, Slany R, Follo M, Borkhardt A | title = The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance | journal = FEBS Lett. | volume = 554 | issue = 1–2 | pages = 10–6 | date = Nov 2003 | pmid = 14596906 | doi = 10.1016/s0014-5793(03)01063-9| s2cid = 19552309 | doi-access = }} and
• TNKS.

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• {{cite journal | vauthors = Richnau N, Aspenström P | title = Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1 | journal = J. Biol. Chem. | volume = 276 | issue = 37 | pages = 35060–70 | year = 2001 | pmid = 11431473 | doi = 10.1074/jbc.M103540200 | doi-access = free }}
• {{cite journal | vauthors = Ghadimi MP, Sanzenbacher R, Thiede B, Wenzel J, Jing Q, Plomann M, Borkhardt A, Kabelitz D, Janssen O | title = Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178) | journal = FEBS Lett. | volume = 519 | issue = 1–3 | pages = 50–8 | year = 2002 | pmid = 12023017 | doi = 10.1016/S0014-5793(02)02709-6 | s2cid = 26765451 }}
• {{cite journal | vauthors = Fujita H, Katoh H, Ishikawa Y, Mori K, Negishi M | title = Rapostlin is a novel effector of Rnd2 GTPase inducing neurite branching | journal = J. Biol. Chem. | volume = 277 | issue = 47 | pages = 45428–34 | year = 2003 | pmid = 12244061 | doi = 10.1074/jbc.M208090200 | doi-access = free }}
• {{cite journal | vauthors = Katoh M, Katoh M | title = FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains | journal = Int. J. Mol. Med. | volume = 11 | issue = 6 | pages = 791–7 | year = 2004 | pmid = 12736724 | doi = 10.3892/ijmm.11.6.791 }}
• {{cite journal | vauthors = Fuchs U, Rehkamp GF, Slany R, Follo M, Borkhardt A | title = The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance | journal = FEBS Lett. | volume = 554 | issue = 1–2 | pages = 10–6 | year = 2003 | pmid = 14596906 | doi = 10.1016/S0014-5793(03)01063-9 | s2cid = 19552309 | doi-access = }}
• {{cite journal | vauthors = Larocca MC, Shanks RA, Tian L, Nelson DL, Stewart DM, Goldenring JR | title = AKAP350 Interaction with cdc42 Interacting Protein 4 at the Golgi Apparatus | journal = Mol. Biol. Cell | volume = 15 | issue = 6 | pages = 2771–81 | year = 2004 | pmid = 15047863 | pmc = 420101 | doi = 10.1091/mbc.E03-10-0757 }}
• {{cite journal | vauthors = Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC | title = Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry | journal = Anal. Chem. | volume = 76 | issue = 10 | pages = 2763–72 | year = 2004 | pmid = 15144186 | doi = 10.1021/ac035352d }}
• {{cite journal | vauthors = Kamioka Y, Fukuhara S, Sawa H, Nagashima K, Masuda M, Matsuda M, Mochizuki N | title = A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis | journal = J. Biol. Chem. | volume = 279 | issue = 38 | pages = 40091–9 | year = 2004 | pmid = 15252009 | doi = 10.1074/jbc.M404899200 | doi-access = free }}
• {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 | bibcode = 2004PNAS..10112130B | doi-access = free }}
• {{cite journal | vauthors = Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ | title = Immunoaffinity profiling of tyrosine phosphorylation in cancer cells | journal = Nat. Biotechnol. | volume = 23 | issue = 1 | pages = 94–101 | year = 2005 | pmid = 15592455 | doi = 10.1038/nbt1046 | s2cid = 7200157 }}
• {{cite journal | vauthors = Zhou FL, Zhang WG, Chen G, Zhao WH, Cao XM, Chen YX, Tian W, Liu J, Liu SH | title = Serological identification and bioinformatics analysis of immunogenic antigens in multiple myeloma | journal = Cancer Immunol. Immunother. | volume = 55 | issue = 8 | pages = 910–7 | year = 2006 | pmid = 16193335 | doi = 10.1007/s00262-005-0074-x | s2cid = 24083118 | pmc = 11030602 }}
• {{cite journal | vauthors = Qian J, Chen W, Lettau M, Podda G, Zörnig M, Kabelitz D, Janssen O | title = Regulation of FasL expression: a SH3 domain containing protein family involved in the lysosomal association of FasL | journal = Cell. Signal. | volume = 18 | issue = 8 | pages = 1327–37 | year = 2006 | pmid = 16318909 | doi = 10.1016/j.cellsig.2005.10.015 }}
• {{cite journal | vauthors = Itoh T, Erdmann KS, Roux A, Habermann B, Werner H, De Camilli P | title = Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteins | journal = Dev. Cell | volume = 9 | issue = 6 | pages = 791–804 | year = 2006 | pmid = 16326391 | doi = 10.1016/j.devcel.2005.11.005 | doi-access = free }}
• {{cite journal | vauthors = Tsujita K, Suetsugu S, Sasaki N, Furutani M, Oikawa T, Takenawa T | title = Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis | journal = J. Cell Biol. | volume = 172 | issue = 2 | pages = 269–79 | year = 2006 | pmid = 16418535 | pmc = 2063556 | doi = 10.1083/jcb.200508091 }}

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