SNX2

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with formin-binding protein 17, but its function is unknown. This protein may form oligomeric complexes with family members.

SNX2 has been shown to interact with FNBP1.{{cite journal | vauthors = Fuchs U, Rehkamp GF, Slany R, Follo M, Borkhardt A | title = The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance | journal = FEBS Letters | volume = 554 | issue = 1–2 | pages = 10–6 | date = Nov 2003 | pmid = 14596906 | doi = 10.1016/S0014-5793(03)01063-9 | s2cid = 19552309 | doi-access = }}{{cite journal | vauthors = Fuchs U, Rehkamp G, Haas OA, Slany R, Kōnig M, Bojesen S, Bohle RM, Damm-Welk C, Ludwig WD, Harbott J, Borkhardt A | title = The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 15 | pages = 8756–61 | date = Jul 2001 | pmid = 11438682 | pmc = 37508 | doi = 10.1073/pnas.121433898 | bibcode = 2001PNAS...98.8756F | doi-access = free }}

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• {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
• {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
• {{cite journal | vauthors = Haft CR, de la Luz Sierra M, Bafford R, Lesniak MA, Barr VA, Taylor SI | title = Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes | journal = Molecular Biology of the Cell | volume = 11 | issue = 12 | pages = 4105–16 | date = Dec 2000 | pmid = 11102511 | pmc = 15060 | doi = 10.1091/mbc.11.12.4105 }}
• {{cite journal | vauthors = Parks WT, Frank DB, Huff C, Renfrew Haft C, Martin J, Meng X, de Caestecker MP, McNally JG, Reddi A, Taylor SI, Roberts AB, Wang T, Lechleider RJ | title = Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases | journal = The Journal of Biological Chemistry | volume = 276 | issue = 22 | pages = 19332–9 | date = Jun 2001 | pmid = 11279102 | doi = 10.1074/jbc.M100606200 | doi-access = free }}
• {{cite journal | vauthors = Fuchs U, Rehkamp G, Haas OA, Slany R, Kōnig M, Bojesen S, Bohle RM, Damm-Welk C, Ludwig WD, Harbott J, Borkhardt A | title = The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 15 | pages = 8756–61 | date = Jul 2001 | pmid = 11438682 | pmc = 37508 | doi = 10.1073/pnas.121433898 | bibcode = 2001PNAS...98.8756F | doi-access = free }}
• {{cite journal | vauthors = Teasdale RD, Loci D, Houghton F, Karlsson L, Gleeson PA | title = A large family of endosome-localized proteins related to sorting nexin 1 | journal = The Biochemical Journal | volume = 358 | issue = Pt 1 | pages = 7–16 | date = Aug 2001 | pmid = 11485546 | pmc = 1222026 | doi = 10.1042/0264-6021:3580007 }}
• {{cite journal | vauthors = Fuchs U, Rehkamp GF, Slany R, Follo M, Borkhardt A | title = The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance | journal = FEBS Letters | volume = 554 | issue = 1–2 | pages = 10–6 | date = Nov 2003 | pmid = 14596906 | doi = 10.1016/S0014-5793(03)01063-9 | s2cid = 19552309 | doi-access = }}
• {{cite journal | vauthors = Gullapalli A, Garrett TA, Paing MM, Griffin CT, Yang Y, Trejo J | title = A role for sorting nexin 2 in epidermal growth factor receptor down-regulation: evidence for distinct functions of sorting nexin 1 and 2 in protein trafficking | journal = Molecular Biology of the Cell | volume = 15 | issue = 5 | pages = 2143–55 | date = May 2004 | pmid = 14978220 | pmc = 404011 | doi = 10.1091/mbc.E03-09-0711 }}
• {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = Aug 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 | bibcode = 2004PNAS..10112130B | doi-access = free }}
• {{cite journal | vauthors = Schaaf CP, Benzing J, Schmitt T, Erz DH, Tewes M, Bartram CR, Janssen JW | title = Novel interaction partners of the TPR/MET tyrosine kinase | journal = FASEB Journal | volume = 19 | issue = 2 | pages = 267–9 | date = Feb 2005 | pmid = 15546961 | doi = 10.1096/fj.04-1558fje | doi-access = free | s2cid = 17142907 }}
• {{cite journal | vauthors = Abdul-Ghani M, Hartman KL, Ngsee JK | title = Abstrakt interacts with and regulates the expression of sorting nexin-2 | journal = Journal of Cellular Physiology | volume = 204 | issue = 1 | pages = 210–8 | date = Jul 2005 | pmid = 15690390 | pmc = 2963638 | doi = 10.1002/jcp.20285 }}
• {{cite journal | vauthors = Carlton JG, Bujny MV, Peter BJ, Oorschot VM, Rutherford A, Arkell RS, Klumperman J, McMahon HT, Cullen PJ | title = Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport | journal = Journal of Cell Science | volume = 118 | issue = Pt 19 | pages = 4527–39 | date = Oct 2005 | pmid = 16179610 | pmc = 1904489 | doi = 10.1242/jcs.02568 }}
• {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nature Biotechnology | volume = 24 | issue = 10 | pages = 1285–92 | date = Oct 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 | s2cid = 14294292 }}
• {{cite journal | vauthors = Rojas R, Kametaka S, Haft CR, Bonifacino JS | title = Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors | journal = Molecular and Cellular Biology | volume = 27 | issue = 3 | pages = 1112–24 | date = Feb 2007 | pmid = 17101778 | pmc = 1800681 | doi = 10.1128/MCB.00156-06 }}
• {{cite journal | vauthors = Skånland SS, Wälchli S, Utskarpen A, Wandinger-Ness A, Sandvig K | title = Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins | journal = Traffic | volume = 8 | issue = 3 | pages = 297–309 | date = Mar 2007 | pmid = 17319803 | doi = 10.1111/j.1600-0854.2006.00527.x | hdl = 10852/11339 | s2cid = 21600584 | hdl-access = free }}

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{{Sorting nexins}}

{{Gene-5-stub}}