Formimidoyltransferase cyclodeaminase

{{Short description|Class of enzymes}}

{{Redirect|FTCD}}

{{protein

| Name = formimidoyltransferase cyclodeaminase

| AltNames = formiminotransferase cyclodeaminase

| caption = Formiminotransferase cyclodeaminase homooctamer, Rattus norvegicus

| image = 2pfd.jpg

| width = 270

| HGNCid = 3974

| Symbol = FTCD

| AltSymbols =

| EntrezGene = 10841

| OMIM = 606806

| RefSeq = NM_006657

| UniProt = O95954

| PDB =

| ECnumber =

| Chromosome = 21

| Arm = q

| Band = 22.3

| LocusSupplementaryData =

}}

Formimidoyltransferase cyclodeaminase or formiminotransferase cyclodeaminase (gene symbol FTCD in humans) is a bifunctional enzyme that catalyzes the following reactions:

• conversion of formiminoglutamate and tetrahydrofolate into formiminotetrahydrofolate and glutamate (glutamate formimidoyltransferase activity, {{EC number|2.1.2.5}})
• subsequent deamination of formiminotetrahydrofolate to 5,10-methenyltetrahydrofolate and ammonia (formimidoyltetrahydrofolate cyclodeaminase activity, {{EC number|4.3.1.4}})

Its name comes from the two activities it catalyzes.