GABPA

This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome c oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down syndrome phenotype.{{cite web | title = Entrez Gene: GABPA GA binding protein transcription factor, alpha subunit 60kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2551}}

GABPA has been shown to interact with Host cell factor C1,{{cite journal | vauthors = Vogel JL, Kristie TM | title = The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP | journal = The EMBO Journal | volume = 19 | issue = 4 | pages = 683–90 | date = Feb 2000 | pmid = 10675337 | pmc = 305606 | doi = 10.1093/emboj/19.4.683 }} Sp1 transcription factor{{cite journal | vauthors = Galvagni F, Capo S, Oliviero S | title = Sp1 and Sp3 physically interact and co-operate with GABP for the activation of the utrophin promoter | journal = Journal of Molecular Biology | volume = 306 | issue = 5 | pages = 985–96 | date = Mar 2001 | pmid = 11237613 | doi = 10.1006/jmbi.2000.4335 | hdl = 2318/141203 | url = https://iris.unito.it/bitstream/2318/141203/1/Sp1%20and%20Sp3%20Physically%20Interact%20and%20Co_4aperto.pdf | hdl-access = free }} and Sp3 transcription factor.

• ETS transcription factor family
• GABPB2

{{reflist}}

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• {{cite journal | vauthors = Chrast R, Chen H, Morris MA, Antonarakis SE | title = Mapping of the human transcription factor GABPA (E4TF1-60) gene to chromosome 21 | journal = Genomics | volume = 28 | issue = 1 | pages = 119–22 | date = Jul 1995 | pmid = 7590737 | doi = 10.1006/geno.1995.1117 }}
• {{cite journal | vauthors = Sawada J, Goto M, Watanabe H, Handa H, Yoshida MC | title = Regional mapping of two subunits of transcription factor E4TF1 to human chromosome | journal = Japanese Journal of Cancer Research | volume = 86 | issue = 1 | pages = 10–2 | date = Jan 1995 | pmid = 7737900 | pmc = 5920589 | doi = 10.1111/j.1349-7006.1995.tb02981.x }}
• {{cite journal | vauthors = Gugneja S, Virbasius JV, Scarpulla RC | title = Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain | journal = Molecular and Cellular Biology | volume = 15 | issue = 1 | pages = 102–11 | date = Jan 1995 | pmid = 7799916 | pmc = 231915 | doi = 10.1128/MCB.15.1.102}}
• {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
• {{cite journal | vauthors = Goto M, Shimizu T, Sawada J, Sawa C, Watanabe H, Ichikawa H, Ohira M, Ohki M, Handa H | title = Assignment of the E4TF1-60 gene to human chromosome 21q21.2-q21.3 | journal = Gene | volume = 166 | issue = 2 | pages = 337–8 | date = Dec 1995 | pmid = 8543189 | doi = 10.1016/0378-1119(95)00575-7 }}
• {{cite journal | vauthors = Sawa C, Goto M, Suzuki F, Watanabe H, Sawada J, Handa H | title = Functional domains of transcription factor hGABP beta1/E4TF1-53 required for nuclear localization and transcription activation | journal = Nucleic Acids Research | volume = 24 | issue = 24 | pages = 4954–61 | date = Dec 1996 | pmid = 9016666 | pmc = 146336 | doi = 10.1093/nar/24.24.4954 }}
• {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
• {{cite journal | vauthors = Batchelor AH, Piper DE, de la Brousse FC, McKnight SL, Wolberger C | title = The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA | journal = Science | volume = 279 | issue = 5353 | pages = 1037–41 | date = Feb 1998 | pmid = 9461436 | doi = 10.1126/science.279.5353.1037 | bibcode = 1998Sci...279.1037B }}
• {{cite journal | vauthors = Suzuki F, Goto M, Sawa C, Ito S, Watanabe H, Sawada J, Handa H | title = Functional interactions of transcription factor human GA-binding protein subunits | journal = The Journal of Biological Chemistry | volume = 273 | issue = 45 | pages = 29302–8 | date = Nov 1998 | pmid = 9792629 | doi = 10.1074/jbc.273.45.29302 | doi-access = free }}
• {{cite journal | vauthors = Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, Yamamoto M | title = Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain | journal = Genes & Development | volume = 13 | issue = 1 | pages = 76–86 | date = Jan 1999 | pmid = 9887101 | pmc = 316370 | doi = 10.1101/gad.13.1.76 }}
• {{cite journal | vauthors = Bannert N, Avots A, Baier M, Serfling E, Kurth R | title = GA-binding protein factors, in concert with the coactivator CREB binding protein/p300, control the induction of the interleukin 16 promoter in T lymphocytes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 4 | pages = 1541–6 | date = Feb 1999 | pmid = 9990060 | pmc = 15509 | doi = 10.1073/pnas.96.4.1541 | bibcode = 1999PNAS...96.1541B | doi-access = free }}
• {{cite journal | vauthors = Sawada J, Simizu N, Suzuki F, Sawa C, Goto M, Hasegawa M, Imai T, Watanabe H, Handa H | title = Synergistic transcriptional activation by hGABP and select members of the activation transcription factor/cAMP response element-binding protein family | journal = The Journal of Biological Chemistry | volume = 274 | issue = 50 | pages = 35475–82 | date = Dec 1999 | pmid = 10585419 | doi = 10.1074/jbc.274.50.35475 | doi-access = free }}
• {{cite journal | vauthors = Guo A, Nie F, Wong-Riley M | title = Human nuclear respiratory factor 2 alpha subunit cDNA: isolation, subcloning, sequencing, and in situ hybridization of transcripts in normal and monocularly deprived macaque visual system | journal = The Journal of Comparative Neurology | volume = 417 | issue = 2 | pages = 221–32 | date = Feb 2000 | pmid = 10660899 | doi = 10.1002/(SICI)1096-9861(20000207)417:2<221::AID-CNE7>3.0.CO;2-4 | s2cid = 25982934 }}
• {{cite journal | vauthors = Vogel JL, Kristie TM | title = The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP | journal = The EMBO Journal | volume = 19 | issue = 4 | pages = 683–90 | date = Feb 2000 | pmid = 10675337 | pmc = 305606 | doi = 10.1093/emboj/19.4.683 }}
• {{cite journal | vauthors = Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML | title = The DNA sequence of human chromosome 21 | journal = Nature | volume = 405 | issue = 6784 | pages = 311–9 | date = May 2000 | pmid = 10830953 | doi = 10.1038/35012518 | bibcode = 2000Natur.405..311H | doi-access = free }}
• {{cite journal | vauthors = Galvagni F, Capo S, Oliviero S | title = Sp1 and Sp3 physically interact and co-operate with GABP for the activation of the utrophin promoter | journal = Journal of Molecular Biology | volume = 306 | issue = 5 | pages = 985–96 | date = Mar 2001 | pmid = 11237613 | doi = 10.1006/jmbi.2000.4335 | hdl = 2318/141203 | url = https://iris.unito.it/bitstream/2318/141203/1/Sp1%20and%20Sp3%20Physically%20Interact%20and%20Co_4aperto.pdf | hdl-access = free }}
• {{cite journal | vauthors = Dhakshinamoorthy S, Porter AG | title = Nitric oxide-induced transcriptional up-regulation of protective genes by Nrf2 via the antioxidant response element counteracts apoptosis of neuroblastoma cells | journal = The Journal of Biological Chemistry | volume = 279 | issue = 19 | pages = 20096–107 | date = May 2004 | pmid = 14985350 | doi = 10.1074/jbc.M312492200 | doi-access = free }}
• {{cite journal | vauthors = Shen G, Hebbar V, Nair S, Xu C, Li W, Lin W, Keum YS, Han J, Gallo MA, Kong AN | title = Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein | journal = The Journal of Biological Chemistry | volume = 279 | issue = 22 | pages = 23052–60 | date = May 2004 | pmid = 15020583 | doi = 10.1074/jbc.M401368200 | doi-access = free }}

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• {{FactorBook|GABP}}

{{PDB Gallery|geneid=2551}}

{{Transcription factors|g1}}

{{DEFAULTSORT:Gabpa}}

Category:Transcription factors

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