ETS transcription factor family

The ETS (Erythroblast Transformation Specific)family is divided into 12 subfamilies, which are listed below:{{cite journal |vauthors=Gutierrez-Hartman A, Duval DL, Bradford AP |title=ETS transcription factors in endocrine systems |journal=Trends Endocrinol Metab |volume=18 |issue=4 |pages=150–8 |year=2007 |pmid=17387021 |doi=10.1016/j.tem.2007.03.002 |s2cid=24617218 }}

All ETS (Erythroblast Transformation Specific) family members are identified through a highly conserved DNA binding domain, the ETS domain, which is a winged helix-turn-helix structure that binds to DNA sites with a central GGA(A/T) DNA sequence. As well as DNA-binding functions, evidence suggests that the ETS domain is also involved in protein-protein interactions.

There is limited similarity outside the ETS DNA binding domain.

Other domains are also present and vary from ETS member to ETS member, including the Pointed domain, a subclass of the SAM domain family.

The ETS family is present throughout the body and is involved in a wide variety of functions including the regulation of cellular differentiation, cell cycle control, cell migration, cell proliferation, apoptosis (programmed cell death) and angiogenesis.

Multiple ETS factors have been found to be associated with cancer, such as through gene fusion. For example, the ERG ETS transcription factor is fused to the EWS gene, resulting in a condition called Ewing's sarcoma.{{cite journal |vauthors=Ida K, Kobayashi S, Taki T, Hanada R, Bessho F, Yamamori S, Sugimoto T, Ohki M, Hayashi Y |title= EWS-FLI-1 and EWS-ERG chimeric mRNAs in Ewing's sarcoma and primitive neuroectodermal tumor |journal= Int J Cancer |volume=63 |issue=4 |pages=500–4 |year=1995 |pmid=7591257 |doi= 10.1002/ijc.2910630407|s2cid= 24841690 }} The fusion of TEL to the JAK2 protein results in early pre-B acute lymphoid leukaemia.{{cite journal |vauthors=Peeters P, Raynaud SD, Cools J, Wlodarska I, Grosgeorge J, Philip P, Monpoux F, Van Rompaey L, Baens M, Van den Berghe H, Marynen P |title= Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia |journal= Blood |volume=90 |issue=7 |pages=2535–40 |year=1997 |doi= 10.1182/blood.V90.7.2535 |pmid=9326218 |doi-access=free }} ERG and ETV1 are known gene fusions found in prostate cancer.{{cite journal | vauthors = Tomlins SA, Rhodes DR, Perner S, Dhanasekaran SM, Mehra R, Sun XW, Varambally S, Cao X, Tchinda J, Kuefer R, Lee C, Montie JE, Shah RB, Pienta KJ, Rubin MA, Chinnaiyan AM | title = Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer | journal = Science | volume = 310 | issue = 5748 | pages = 644–8 |date=October 2005 | pmid = 16254181 | doi = 10.1126/science.1117679 | bibcode = 2005Sci...310..644T | s2cid = 85788789 }}

In addition, ETS factors, e.g. the vertebrate Etv1 and the invertebrate Ast-1, have been shown to be important players in the specification and differentiation of dopaminergic neurons in both C. elegans and olfactory bulbs of mice.{{cite journal |vauthors=Flames N, Hobert O |title=Gene regulatory logic of dopaminergic neuron differentiation |journal=Nature |volume=458 |pages=885–890 |year=2009 |doi=10.1038/nature07929 |pmid=19287374 |issue=7240 |pmc=2671564}}

Amongst members of the ETS family, there is extensive conservation in the DNA-binding ETS domain and, therefore, a lot of redundancy in DNA binding. It is thought that interactions with other proteins (eg: Modulator of the activity of Ets called Mae) is one way in which specific binding to DNA is achieved. Transcription factor Ets are a site of signalling convergence.{{cite journal | vauthors= Verger A, Duterque-Coquillaud M |title= When Ets transcription factors meet their partners |journal= BioEssays |volume=24 |issue=4 |pages=362–70 |year=2002 |pmid=11948622 |doi= 10.1002/bies.10068 }}

ETS factors act as transcriptional repressors, transcriptional activators, or both.{{cite journal |author= Sharrocks AD |title= The ETS-domain transcription factor family |journal= Nat Rev Mol Cell Biol |volume=2 |issue=11 |pages=827–37 |year=2001 |pmid=11715049 |doi= 10.1038/35099076 |s2cid= 5407789 }}

{{Reflist}}

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• {{cite journal | vauthors= Blair DG, Athanasiou M |title= Ets and retroviruses - transduction and activation of members of the Ets oncogene family in viral oncogenesis |journal= Oncogene |volume=19 |issue=55 |pages=6472–81 |year=2000 |pmid=11175363 |doi= 10.1038/sj.onc.1204046 |doi-access=free }}
• {{cite journal | vauthors= Li R, Pei H, Watson DK |title= Regulation of Ets function by protein - protein interactions |journal= Oncogene |volume=19 |issue=55 |pages=6514–23 |year=2000 |pmid=11175367 |doi= 10.1038/sj.onc.1204035 |doi-access=free }}
• {{cite journal | author= Mimeault M |title= Structure-function studies of ETS transcription factors |journal= Crit Rev Oncog |volume=11 |issue=3–4 |pages=227–53 |year=2000 |pmid=11358268 |doi=10.1615/critrevoncog.v11.i34.20}}
• {{cite journal | vauthors= Oikawa T, Yamada T |title= Molecular biology of the Ets family of transcription factors |journal= Gene |volume=303 |pages=11–34 |year=2003 |pmid=12559563 |doi= 10.1016/S0378-1119(02)01156-3 }}
• {{cite journal | vauthors= Sementchenko VI, Watson DK |title= Ets target genes: past, present and future |journal= Oncogene |volume=19 |issue=55 |pages=6533–48 |year=2000 |pmid=11175369 |doi= 10.1038/sj.onc.1204034 |doi-access=free }}
• {{cite journal | vauthors= Verger A, Duterque-Coquillaud M |title= When Ets transcription factors meet their partners |journal= BioEssays |volume=24 |issue=4 |pages=362–70 |year=2002 |pmid=11948622 |doi= 10.1002/bies.10068 }}
• {{cite journal | vauthors= Nunn M, Seeburg P, Moscovici C, Duesberg P |title= Tripartite structure of the avian erythroblastosis virus E26 transforming gene |journal= Nature |volume=306 |pages=391–95 |year=1983 |doi= 10.1038/306391a0 |pmid=6316155 |issue=5941|bibcode= 1983Natur.306..391N |s2cid= 4302399 }}

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{{Transcription factors|g3}}

{{DEFAULTSORT:Ets Transcription Factor Family}}

Category:Gene expression

Category:Transcription factors

Category:Protein families