GAL3ST1
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Galactosylceramide sulfotransferase is an enzyme that in humans is encoded by the GAL3ST1 gene.{{cite journal | title = Toward a complete human genome sequence | journal = Genome Res | volume = 8 | issue = 11 | pages = 1097–108 |date=Jan 1999 | pmid = 9847074 | doi = 10.1101/gr.8.11.1097| last1 = Sanger Centre | first1 = The | last2 = Washington University Genome Sequencing Cente | first2 = The | doi-access = free }}{{cite journal |vauthors=Honke K, Tsuda M, Hirahara Y, Ishii A, Makita A, Wada Y | title = Molecular cloning and expression of cDNA encoding human 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase | journal = J Biol Chem | volume = 272 | issue = 8 | pages = 4864–8 |date=Apr 1997 | pmid = 9030544 | doi =10.1074/jbc.272.8.4864 | doi-access = free }}{{cite web | title = Entrez Gene: GAL3ST1 galactose-3-O-sulfotransferase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9514}}
Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. The product of this gene is galactosylceramide sulfotransferase which catalyzes the conversion between 3'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3',5'-bisphosphate + galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma.
References
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Further reading
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- {{cite journal | author=Siegrist HP |title=Age-dependent modulation of 3'-phosphoadenosine-5'-phosphosulfate-galactosylceramide sulfotransferase by lipids extracted from the microsomal membranes and artificial lipid mixtures |journal=Biochim. Biophys. Acta |volume=489 |issue= 1 |pages= 58–63 |year= 1977 |pmid= 911873 |doi= 10.1016/0005-2760(77)90231-4|name-list-style=vanc| author2=Jutzi H | author3=Steck AJ | display-authors=3 | last4=Burkart | first4=T | last5=Wiesmann | first5=U | last6=Herschkowitz | first6=N }}
- {{cite journal | author=Stein C |title=Cloning and expression of human arylsulfatase A |journal=J. Biol. Chem. |volume=264 |issue= 2 |pages= 1252–9 |year= 1989 |pmid= 2562955 |name-list-style=vanc| author2=Gieselmann V | author3=Kreysing J | display-authors=3 | last4=Schmidt | first4=B | last5=Pohlmann | first5=R | last6=Waheed | first6=A | last7=Meyer | first7=HE | last8=O'Brien | first8=JS | last9=Von Figura | first9=K |doi=10.1016/S0021-9258(19)85079-2 |doi-access=free }}
- {{cite journal |vauthors=Fleischer B, Zambrano F |title=Localization of cerebroside-sulfotransferase activity in the Golgi apparatus of rat kidney |journal=Biochem. Biophys. Res. Commun. |volume=52 |issue= 3 |pages= 951–8 |year= 1973 |pmid= 4710574 |doi=10.1016/0006-291X(73)91029-2 }}
- {{cite journal |vauthors=Farrell DF, McKhann GM |title=Characterization of cerebroside sulfotransferase from rat brain |journal=J. Biol. Chem. |volume=246 |issue= 15 |pages= 4694–702 |year= 1971 |doi=10.1016/S0021-9258(18)61991-X |pmid= 5562350 |doi-access=free }}
- {{cite journal | author=Costantino-Ceccarini E |title=Distribution of lipid synthesizing enzymes, 2',3'-cyclic nucleotide 3'-phosphodiesterase, and myelin proteins in rat forebrain subfractions during development |journal=Neurochem. Res. |volume=7 |issue= 1 |pages= 1–12 |year= 1982 |pmid= 6280086 |doi=10.1007/BF00965064 |name-list-style=vanc| author2=Waehneldt TV | author3=Ginalski H | display-authors=3 | last4=Burgisser | first4=Philippe | last5=Reigner | first5=Jacqueline | last6=Matthieu | first6=Jean-Marie |s2cid=32069166 }}
- {{cite journal |vauthors=Benjamins JA, Hadden T, Skoff RP |title=Cerebroside sulfotransferase in Golgi-enriched fractions from rat brain |journal=J. Neurochem. |volume=38 |issue= 1 |pages= 233–41 |year= 1982 |pmid= 6955451 |doi=10.1111/j.1471-4159.1982.tb10875.x |s2cid=23693243 }}
- {{cite journal | author=Honke K |title=Purification and characterization of 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase from human renal cancer cells |journal=J. Biochem. |volume=119 |issue= 3 |pages= 421–7 |year= 1996 |pmid= 8830034 |doi= 10.1093/oxfordjournals.jbchem.a021258|name-list-style=vanc| author2=Yamane M | author3=Ishii A | display-authors=3 | last4=Kobayashi | first4=T | last5=Makita | first5=A }}
- {{cite journal | author=Tsuda M |title=Cancer-associated alternative usage of multiple promoters of human GalCer sulfotransferase gene |journal=Eur. J. Biochem. |volume=267 |issue= 9 |pages= 2672–9 |year= 2000 |pmid= 10785389 |doi=10.1046/j.1432-1327.2000.01281.x |name-list-style=vanc| author2=Egashira M | author3=Niikawa N | display-authors=3 | last4=Wada | first4=Yoshinao | last5=Honke | first5=Koichi |doi-access=free}}
- {{cite journal |vauthors=Eckhardt M, Fewou SN, Ackermann I, Gieselmann V |title=N-glycosylation is required for full enzymic activity of the murine galactosylceramide sulphotransferase |journal=Biochem. J. |volume=368 |issue= Pt 1 |pages= 317–24 |year= 2002 |pmid= 12175333 |doi= 10.1042/BJ20020946 | pmc=1222978 }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | author=Collins JE |title=A genome annotation-driven approach to cloning the human ORFeome |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 |name-list-style=vanc| author2=Wright CL | author3=Edwards CA | display-authors=3 | last4=Davis | first4=Matthew P | last5=Grinham | first5=James A | last6=Cole | first6=Charlotte G | last7=Goward | first7=Melanie E | last8=Aguado | first8=Begoña | last9=Mallya | first9=Meera |doi-access=free }}
- {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
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