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GAPVD1

{{Short description|Protein-coding gene in the species Homo sapiens}}

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GTPase activating protein and VPS9 domains 1, also known as GAPVD1, Gapex-5 and RME-6 is a protein which in humans is encoded by the GAPVD1 gene.{{cite web | title = Entrez Gene: GAPVD1 GTPase activating protein and VPS9 domains 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26130}}{{cite journal |vauthors=Hunker CM, Galvis A, Kruk I, Giambini H, Veisaga ML, Barbieri MA | title = Rab5-activating protein 6, a novel endosomal protein with a role in endocytosis | journal = Biochem. Biophys. Res. Commun. | volume = 340 | issue = 3 | pages = 967–75 |date=February 2006 | pmid = 16410077 | doi = 10.1016/j.bbrc.2005.12.099 }}

Function

GAPVD1 is Rab GTPase guanine nucleotide exchange factor essential for activation of RAB5A during engulfment of apoptotic cells.{{cite journal |vauthors=Kitano M, Nakaya M, Nakamura T, Nagata S, Matsuda M | title = Imaging of Rab5 activity identifies essential regulators for phagosome maturation | journal = Nature | volume = 453 | issue = 7192 | pages = 241–5 |date=May 2008 | pmid = 18385674 | doi = 10.1038/nature06857 | bibcode = 2008Natur.453..241K | doi-access = free }} GAPVD1 is also involved in the degradation of the epidermal growth factor receptor.{{cite journal |vauthors=Su X, Kong C, Stahl PD | title = GAPex-5 mediates ubiquitination, trafficking, and degradation of epidermal growth factor receptor | journal = J. Biol. Chem. | volume = 282 | issue = 29 | pages = 21278–84 |date=July 2007 | pmid = 17545148 | doi = 10.1074/jbc.M703725200 | doi-access = free }}

Gapex-5 mediated activation of Rab5 has been implicated in the insulin stimulated formation of plasma membrane phosphatidylinositol-3-phosphate.{{cite journal |vauthors=Lodhi IJ, Bridges D, Chiang SH, Zhang Y, Cheng A, Geletka LM, Weisman LS, Saltiel AR | title = Insulin Stimulates Phosphatidylinositol 3-Phosphate Production via the Activation of Rab5 | journal = Mol. Biol. Cell | volume = 19 | issue = 7 | pages = 2718–28 |date=July 2008 | pmid = 18434594 | pmc = 2441665 | doi = 10.1091/mbc.E08-01-0105 }}

Structure

Based on sequence homology, mammalian Gapex-5 has been shown to have an amino-terminal Ras GAP domain, a central polyproline (SH3 binding) region and a carboxy-terminal Rab GEF domain. The RabGEF domain has been suggested to activate Rab5{{cite journal |vauthors=Su X, Lodhi IJ, Saltiel AR, Stahl PD | title = Insulin-stimulated Interaction between insulin receptor substrate 1 and p85alpha and activation of protein kinase B/Akt require Rab5 | journal = J. Biol. Chem. | volume = 281 | issue = 38 | pages = 27982–90 |date=September 2006 | pmid = 16880210 | doi = 10.1074/jbc.M602873200 | doi-access = free }} and Rab31.{{cite journal |vauthors=Lodhi IJ, Chiang SH, Chang L, Vollenweider D, Watson RT, Inoue M, Pessin JE, Saltiel AR | title = Gapex-5, a Rab31 Guanine Nucleotide Exchange Factor that Regulates Glut4 Trafficking in Adipocytes | journal = Cell Metab. | volume = 5 | issue = 1 | pages = 59–72 |date=January 2007 | pmid = 17189207 | pmc = 1779820 | doi = 10.1016/j.cmet.2006.12.006 }}

References

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Further reading

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  • {{cite journal |vauthors=Su X, Kong C, Stahl PD |title=GAPex-5 mediates ubiquitination, trafficking, and degradation of epidermal growth factor receptor |journal=J. Biol. Chem. |volume=282 |issue= 29 |pages= 21278–84 |year= 2007 |pmid= 17545148 |doi= 10.1074/jbc.M703725200 |doi-access= free }}
  • {{cite journal |vauthors=Hunker CM, Galvis A, Kruk I |title=Rab5-activating protein 6, a novel endosomal protein with a role in endocytosis |journal=Biochem. Biophys. Res. Commun. |volume=340 |issue= 3 |pages= 967–75 |year= 2006 |pmid= 16410077 |doi= 10.1016/j.bbrc.2005.12.099 |display-authors=etal}}
  • {{cite journal |vauthors=Jin J, Smith FD, Stark C |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 |s2cid=2371325 |display-authors=etal|doi-access=free |bibcode=2004CBio...14.1436J }}
  • {{cite journal |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |bibcode=2004PNAS..10112130B |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Nagase T, Kikuno R, Ishikawa K |title=Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=7 |issue= 2 |pages= 143–50 |year= 2000 |pmid= 10819331 |doi=10.1093/dnares/7.2.143 |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }}
  • {{cite journal |vauthors=Adams MD, Kerlavage AR, Fleischmann RD |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3–174 |year= 1995 |pmid= 7566098 |url=http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf |display-authors=etal}}

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