RAB5A

RAB5A localizes to early endosomes where it is involved in the recruitment of RAB7A and the maturation of these compartments to early endosomes.{{cite journal | vauthors = Huotari J, Helenius A | title = Endosome maturation | journal = The EMBO Journal | volume = 30 | issue = 17 | pages = 3481–500 | date = Aug 2011 | pmid = 21878991 | doi=10.1038/emboj.2011.286 | pmc=3181477}} It drives the maturation of endosomes by transporting vacuolar (H+)-ATPases (V-ATPases) from trans-Golgi network to endocytic vesicles.{{cite journal | vauthors = Zhang C, Li A, Zhang X, Xiao H | title = A novel TIP30 protein complex regulates EGF receptor signaling and endocytic degradation | journal = The Journal of Biological Chemistry | volume = 286 | issue = 11 | pages = 9373–81 | date = Mar 2011 | pmid = 21252234 | doi = 10.1074/jbc.M110.207720 | pmc=3058969| doi-access = free }}

RAB5A has been shown to interact with:

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• CHML,{{cite journal | vauthors = Anant JS, Desnoyers L, Machius M, Demeler B, Hansen JC, Westover KD, Deisenhofer J, Seabra MC | title = Mechanism of Rab geranylgeranylation: formation of the catalytic ternary complex | journal = Biochemistry | volume = 37 | issue = 36 | pages = 12559–68 | date = Sep 1998 | pmid = 9730828 | doi = 10.1021/bi980881a }}{{cite journal | vauthors = Cremers FP, Armstrong SA, Seabra MC, Brown MS, Goldstein JL | title = REP-2, a Rab escort protein encoded by the choroideremia-like gene | journal = The Journal of Biological Chemistry | volume = 269 | issue = 3 | pages = 2111–7 | date = Jan 1994 | doi = 10.1016/S0021-9258(17)42142-9 | pmid = 8294464 | doi-access = free }}
• RABEP1,{{cite journal | vauthors = Xiao GH, Shoarinejad F, Jin F, Golemis EA, Yeung RS | title = The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis | journal = The Journal of Biological Chemistry | volume = 272 | issue = 10 | pages = 6097–100 | date = Mar 1997 | pmid = 9045618 | doi = 10.1074/jbc.272.10.6097| doi-access = free| hdl = 20.500.12613/9244 | hdl-access = free }}{{cite journal | vauthors = Vitale G, Rybin V, Christoforidis S, Thornqvist P, McCaffrey M, Stenmark H, Zerial M | title = Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5 | journal = The EMBO Journal | volume = 17 | issue = 7 | pages = 1941–51 | date = Apr 1998 | pmid = 9524117 | pmc = 1170540 | doi = 10.1093/emboj/17.7.1941 }}{{cite journal | vauthors = Stenmark H, Vitale G, Ullrich O, Zerial M | title = Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion | journal = Cell | volume = 83 | issue = 3 | pages = 423–32 | date = Nov 1995 | pmid = 8521472 | doi = 10.1016/0092-8674(95)90120-5| s2cid = 18768939 | doi-access = free }}{{cite journal | vauthors = Valsdottir R, Hashimoto H, Ashman K, Koda T, Storrie B, Nilsson T | title = Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER | journal = FEBS Letters | volume = 508 | issue = 2 | pages = 201–9 | date = Nov 2001 | pmid = 11718716 | doi = 10.1016/s0014-5793(01)02993-3| s2cid = 21545088 | doi-access = free }}
• SDCBP,{{cite journal | vauthors = Tomoda T, Kim JH, Zhan C, Hatten ME | title = Role of Unc51.1 and its binding partners in CNS axon outgrowth | journal = Genes & Development | volume = 18 | issue = 5 | pages = 541–58 | date = Mar 2004 | pmid = 15014045 | pmc = 374236 | doi = 10.1101/gad.1151204 }} and
• ZFYVE20{{cite journal | vauthors = Nielsen E, Christoforidis S, Uttenweiler-Joseph S, Miaczynska M, Dewitte F, Wilm M, Hoflack B, Zerial M | title = Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain | journal = The Journal of Cell Biology | volume = 151 | issue = 3 | pages = 601–12 | date = Oct 2000 | pmid = 11062261 | pmc = 2185588 | doi = 10.1083/jcb.151.3.601}}

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• {{cite journal | vauthors = Bucci C, Parton RG, Mather IH, Stunnenberg H, Simons K, Hoflack B, Zerial M | title = The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway | journal = Cell | volume = 70 | issue = 5 | pages = 715–28 | date = Sep 1992 | pmid = 1516130 | doi = 10.1016/0092-8674(92)90306-W | doi-access = free }}
• {{cite journal | vauthors = Zahraoui A, Touchot N, Chardin P, Tavitian A | title = The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion | journal = The Journal of Biological Chemistry | volume = 264 | issue = 21 | pages = 12394–401 | date = Jul 1989 | doi = 10.1016/S0021-9258(18)63872-4 | pmid = 2501306 | doi-access = free }}
• {{cite journal | vauthors = Farnsworth CC, Seabra MC, Ericsson LH, Gelb MH, Glomset JA | title = Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 91 | issue = 25 | pages = 11963–7 | date = Dec 1994 | pmid = 7991565 | pmc = 45356 | doi = 10.1073/pnas.91.25.11963 | bibcode = 1994PNAS...9111963F | doi-access = free }}
• {{cite journal | vauthors = Cremers FP, Armstrong SA, Seabra MC, Brown MS, Goldstein JL | title = REP-2, a Rab escort protein encoded by the choroideremia-like gene | journal = The Journal of Biological Chemistry | volume = 269 | issue = 3 | pages = 2111–7 | date = Jan 1994 | doi = 10.1016/S0021-9258(17)42142-9 | pmid = 8294464 | doi-access = free }}
• {{cite journal | vauthors = Stenmark H, Vitale G, Ullrich O, Zerial M | title = Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion | journal = Cell | volume = 83 | issue = 3 | pages = 423–32 | date = Nov 1995 | pmid = 8521472 | doi = 10.1016/0092-8674(95)90120-5 | s2cid = 18768939 | doi-access = free }}
• {{cite journal | vauthors = Vita F, Soranzo MR, Borelli V, Bertoncin P, Zabucchi G | title = Subcellular localization of the small GTPase Rab5a in resting and stimulated human neutrophils | journal = Experimental Cell Research | volume = 227 | issue = 2 | pages = 367–73 | date = Sep 1996 | pmid = 8831575 | doi = 10.1006/excr.1996.0286 }}
• {{cite journal | vauthors = Xiao GH, Shoarinejad F, Jin F, Golemis EA, Yeung RS | title = The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis | journal = The Journal of Biological Chemistry | volume = 272 | issue = 10 | pages = 6097–100 | date = Mar 1997 | pmid = 9045618 | doi = 10.1074/jbc.272.10.6097 | doi-access = free| hdl = 20.500.12613/9244 | hdl-access = free }}
• {{cite journal | vauthors = Simonsen A, Lippé R, Christoforidis S, Gaullier JM, Brech A, Callaghan J, Toh BH, Murphy C, Zerial M, Stenmark H | title = EEA1 links PI(3)K function to Rab5 regulation of endosome fusion | journal = Nature | volume = 394 | issue = 6692 | pages = 494–8 | date = Jul 1998 | pmid = 9697774 | doi = 10.1038/28879 | bibcode = 1998Natur.394..494S | s2cid = 4305220 }}
• {{cite journal | vauthors = Anant JS, Desnoyers L, Machius M, Demeler B, Hansen JC, Westover KD, Deisenhofer J, Seabra MC | title = Mechanism of Rab geranylgeranylation: formation of the catalytic ternary complex | journal = Biochemistry | volume = 37 | issue = 36 | pages = 12559–68 | date = Sep 1998 | pmid = 9730828 | doi = 10.1021/bi980881a }}
• {{cite journal | vauthors = Bucci C, Chiariello M, Lattero D, Maiorano M, Bruni CB | title = Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1) | journal = Biochemical and Biophysical Research Communications | volume = 258 | issue = 3 | pages = 657–62 | date = May 1999 | pmid = 10329441 | doi = 10.1006/bbrc.1999.0651 }}
• {{cite journal | vauthors = Callaghan J, Nixon S, Bucci C, Toh BH, Stenmark H | title = Direct interaction of EEA1 with Rab5b | journal = European Journal of Biochemistry | volume = 265 | issue = 1 | pages = 361–6 | date = Oct 1999 | pmid = 10491193 | doi = 10.1046/j.1432-1327.1999.00743.x | doi-access = free }}
• {{cite journal | vauthors = Shisheva A, Chinni SR, DeMarco C | title = General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications | journal = Biochemistry | volume = 38 | issue = 36 | pages = 11711–21 | date = Sep 1999 | pmid = 10512627 | doi = 10.1021/bi990200r }}
• {{cite journal | vauthors = Masuda ES, Luo Y, Young C, Shen M, Rossi AB, Huang BC, Yu S, Bennett MK, Payan DG, Scheller RH | title = Rab37 is a novel mast cell specific GTPase localized to secretory granules | journal = FEBS Letters | volume = 470 | issue = 1 | pages = 61–4 | date = Mar 2000 | pmid = 10722846 | doi = 10.1016/S0014-5793(00)01288-6 | s2cid = 38218555 }}
• {{cite journal | vauthors = Hoffenberg S, Liu X, Nikolova L, Hall HS, Dai W, Baughn RE, Dickey BF, Barbieri MA, Aballay A, Stahl PD, Knoll BJ | title = A novel membrane-anchored Rab5 interacting protein required for homotypic endosome fusion | journal = The Journal of Biological Chemistry | volume = 275 | issue = 32 | pages = 24661–9 | date = Aug 2000 | pmid = 10818110 | doi = 10.1074/jbc.M909600199 | doi-access = free }}
• {{cite journal | vauthors = Nielsen E, Christoforidis S, Uttenweiler-Joseph S, Miaczynska M, Dewitte F, Wilm M, Hoflack B, Zerial M | title = Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain | journal = The Journal of Cell Biology | volume = 151 | issue = 3 | pages = 601–12 | date = Oct 2000 | pmid = 11062261 | pmc = 2185588 | doi = 10.1083/jcb.151.3.601 }}
• {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
• {{cite journal | vauthors = Lanzetti L, Rybin V, Malabarba MG, Christoforidis S, Scita G, Zerial M, Di Fiore PP | title = The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5 | journal = Nature | volume = 408 | issue = 6810 | pages = 374–7 | date = Nov 2000 | pmid = 11099046 | doi = 10.1038/35042605 | bibcode = 2000Natur.408..374L | s2cid = 4405293 }}
• {{cite journal | vauthors = Wolf RM, Wilkes JJ, Chao MV, Resh MD | title = Tyrosine phosphorylation of p190 RhoGAP by Fyn regulates oligodendrocyte differentiation | journal = Journal of Neurobiology | volume = 49 | issue = 1 | pages = 62–78 | date = Oct 2001 | pmid = 11536198 | doi = 10.1002/neu.1066 }}
• {{cite journal | vauthors = Seachrist JL, Laporte SA, Dale LB, Babwah AV, Caron MG, Anborgh PH, Ferguson SS | title = Rab5 association with the angiotensin II type 1A receptor promotes Rab5 GTP binding and vesicular fusion | journal = The Journal of Biological Chemistry | volume = 277 | issue = 1 | pages = 679–85 | date = Jan 2002 | pmid = 11682489 | doi = 10.1074/jbc.M109022200 | doi-access = free }}

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