GNAQ

{{Further|Gq alpha subunit}}

Guanine nucleotide-binding proteins are a family of heterotrimeric proteins that couple cell surface, 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GDP for GTP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. The G protein alpha and beta-gamma subunits are capable of regulating various cellular effectors. Activation is terminated by a GTPase intrinsic to the G-alpha subunit. G-alpha-q is the alpha subunit of one of the heterotrimeric GTP-binding proteins that mediates stimulation of phospholipase C-beta (MIM 600230).[supplied by OMIM]{{cite web | title = Entrez Gene: GNAQ guanine nucleotide binding protein (G protein), q polypeptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2776}}

Mutations in this gene have been found associated to cases of Sturge–Weber syndrome and port-wine stains.{{cite journal | vauthors = Shirley MD, Tang H, Gallione CJ, Baugher JD, Frelin LP, Cohen B, North PE, Marchuk DA, Comi AM, Pevsner J | title = Sturge-Weber syndrome and port-wine stains caused by somatic mutation in GNAQ. | journal = The New England Journal of Medicine | volume = 368 | issue = 21 | pages = 1971–9 | date = May 23, 2013 | pmid = 23656586 | doi = 10.1056/NEJMoa1213507 | pmc=3749068}}

GNAQ has been shown to interact with:

• Beta adrenergic receptor kinase,{{cite journal | vauthors = Day PW, Carman CV, Sterne-Marr R, Benovic JL, Wedegaertner PB | title = Differential interaction of GRK2 with members of the G alpha q family | journal = Biochemistry | volume = 42 | issue = 30 | pages = 9176–84 | date = August 2003 | pmid = 12885252 | doi = 10.1021/bi034442+ }}
• Bruton's tyrosine kinase,{{cite journal | vauthors = Ma YC, Huang XY | title = Identification of the binding site for Gqalpha on its effector Bruton's tyrosine kinase | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 21 | pages = 12197–201 | date = October 1998 | pmid = 9770463 | pmc = 22808 | doi = 10.1073/pnas.95.21.12197| bibcode = 1998PNAS...9512197M | doi-access = free }}
• RGS16
• RGS4{{cite journal | vauthors = Druey KM, Sullivan BM, Brown D, Fischer ER, Watson N, Blumer KJ, Gerfen CR, Scheschonka A, Kehrl JH | title = Expression of GTPase-deficient Gialpha2 results in translocation of cytoplasmic RGS4 to the plasma membrane | journal = J. Biol. Chem. | volume = 273 | issue = 29 | pages = 18405–10 | date = July 1998 | pmid = 9660808 | doi = 10.1074/jbc.273.29.18405| doi-access = free }}
• RIC8A,{{cite journal | vauthors = Klattenhoff C, Montecino M, Soto X, Guzmán L, Romo X, García MA, Mellstrom B, Naranjo JR, Hinrichs MV, Olate J | title = Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol | journal = J. Cell. Physiol. | volume = 195 | issue = 2 | pages = 151–7 | date = May 2003 | pmid = 12652642 | doi = 10.1002/jcp.10300 | hdl = 10533/174200 | s2cid = 84975473 | hdl-access = free }}{{cite journal | vauthors = Tall GG, Krumins AM, Gilman AG | title = Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor | journal = J. Biol. Chem. | volume = 278 | issue = 10 | pages = 8356–62 | date = March 2003 | pmid = 12509430 | doi = 10.1074/jbc.M211862200 | doi-access = free }} and
• Sodium-hydrogen antiporter 3 regulator 1.{{cite journal | vauthors = Rochdi MD, Watier V, La Madeleine C, Nakata H, Kozasa T, Parent JL | title = Regulation of GTP-binding protein alpha q (Galpha q) signaling by the ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50) | journal = J. Biol. Chem. | volume = 277 | issue = 43 | pages = 40751–9 | date = October 2002 | pmid = 12193606 | doi = 10.1074/jbc.M207910200 | doi-access = free }}

• List of genes mutated in pigmented cutaneous lesions

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• {{cite journal | vauthors = Europe-Finner GN, Phaneuf S, Watson SP, López Bernal A | title = Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy. | journal = Endocrinology | volume = 132 | issue = 6 | pages = 2484–90 | year = 1993 | pmid = 8504751 | doi = 10.1210/endo.132.6.8504751 }}
• {{cite journal | vauthors = Laugwitz KL, Allgeier A, Offermanns S, Spicher K, Van Sande J, Dumont JE, Schultz G | title = The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 1 | pages = 116–20 | year = 1996 | pmid = 8552586 | pmc = 40189 | doi = 10.1073/pnas.93.1.116 | bibcode = 1996PNAS...93..116L | doi-access = free }}
• {{cite journal | vauthors = Denker SP, McCaffery JM, Palade GE, Insel PA, Farquhar MG | title = Differential distribution of alpha subunits and beta gamma subunits of heterotrimeric G proteins on Golgi membranes of the exocrine pancreas. | journal = J. Cell Biol. | volume = 133 | issue = 5 | pages = 1027–40 | year = 1996 | pmid = 8655576 | pmc = 2120853 | doi = 10.1083/jcb.133.5.1027 }}
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• {{cite journal | vauthors = Gomeza J, Mary S, Brabet I, Parmentier ML, Restituito S, Bockaert J, Pin JP | title = Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists. | journal = Mol. Pharmacol. | volume = 50 | issue = 4 | pages = 923–30 | year = 1996 | pmid = 8863838 }}
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• {{cite journal | vauthors = Gabbeta J, Yang X, Kowalska MA, Sun L, Dhanasekaran N, Rao AK | title = Platelet signal transduction defect with Galpha subunit dysfunction and diminished Galphaq in a patient with abnormal platelet responses. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 16 | pages = 8750–5 | year = 1997 | pmid = 9238049 | pmc = 23110 | doi = 10.1073/pnas.94.16.8750 | bibcode = 1997PNAS...94.8750G | doi-access = free }}

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{{PDB Gallery|geneid=2776}}

{{Intracellular signaling peptides and proteins}}

{{GTPases}}