Gary Ruvkun

Ruvkun was born into a Jewish family, the son of Samuel and Dora (née Gurevich) Ruvkun.{{Cite web |title=Jewish Nobel Prize Winners in Medicine |url=https://www.jinfo.org/Nobels_Medicine.html |access-date=October 7, 2024 |website=www.jinfo.org |archive-date=August 4, 2024 |archive-url=https://web.archive.org/web/20240804124114/https://www.jinfo.org/Nobels_Medicine.html |url-status=live }}

Ruvkun received a Bachelor of Arts (BA) with a major in biophysics from the University of California, Berkeley in 1973. He received a Doctor of Philosophy (PhD) in biophysics from Harvard University in 1982.{{Cite web |title=PI BIO |url=https://ccib.mgh.harvard.edu/ruvkun |access-date=October 7, 2024 |website=Center for Computational and Integrative Biology |archive-date=October 8, 2024 |archive-url=https://web.archive.org/web/20241008022650/https://ccib.mgh.harvard.edu/ruvkun |url-status=live }} He conducted his doctoral studies in the laboratory of Frederick M. Ausubel, where he investigated bacterial nitrogen fixation genes. Ruvkun completed postdoctoral research with Robert Horvitz at the Massachusetts Institute of Technology (MIT) and Walter Gilbert of Harvard.{{Cite web |url=http://www.hms.harvard.edu/dms/bbs/fac/ruvkun.html |title=Harvard Medical School faculty page |access-date=February 6, 2009 |archive-date=February 3, 2009 |archive-url=https://web.archive.org/web/20090203235730/http://www.hms.harvard.edu/dms/bbs/fac/ruvkun.html |url-status=live }}

Ruvkun's research revealed that the miRNA lin-4, a 22 nucleotide regulatory RNA discovered in 1992 by Victor Ambros' lab, regulates its target mRNA lin-14 by forming imperfect RNA duplexes to down-regulate translation. The first indication that the key regulatory element of the lin-14 gene recognized by the lin-4 gene product was in the lin-14 3’ untranslated region came from the analysis of lin-14 gain-of-function mutations which showed that they are deletions of conserved elements in the lin-14 3’ untranslated region. Deletion of these elements relieves the normal late stage-specific repression of LIN-14 protein production, and lin-4 is necessary for that repression by the normal lin-14 3' untranslated region.{{Cite journal

| pmid = 1916265

| year = 1991

| last1 = Arasu | first1 = P.

| last2 = Wightman | first2 = B.

| last3 = Ruvkun | first3 = G.

| title = Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28

| volume = 5

| issue = 10

| pages = 1825–1833

| journal = Genes & Development

| doi = 10.1101/gad.5.10.1825

| doi-access = free

}}{{Cite journal

| pmid = 1916264

| year = 1991

| last1 = Wightman | first1 = B.

| last2 = Bürglin | first2 = T. R.

| last3 = Gatto | first3 = J.

| last4 = Arasu | first4 = P.

| last5 = Ruvkun | first5 = G.

| title = Negative regulatory sequences in the lin-14 3'-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development

| volume = 5

| issue = 10

| pages = 1813–1824

| journal = Genes & Development

| doi = 10.1101/gad.5.10.1813

| doi-access = free

}} In a key breakthrough, the Ambros lab discovered that lin-4 encodes a very small RNA product, defining the 22 nucleotide miRNAs. When Ambros and Ruvkun compared the sequence of the lin-4 miRNA and the lin-14 3’ untranslated region, they discovered that the lin-4 RNA base pairs with conserved bulges and loops to the 3’ untranslated region of the lin-14 target mRNA, and that the lin-14 gain of function mutations delete these lin-14 complementary sites to relieve the normal repression of translation by lin-4. In addition, they showed that the lin-14 3' untranslated region could confer this lin-4-dependent translational repression on unrelated mRNAs by creating chimeric mRNAs that were lin-4-responsive. In 1993, Ruvkun reported in the journal Cell on the regulation of lin-14 by lin-4.{{Cite journal

| pmid = 8252622

| year = 1993

| last1 = Wightman | first1 = B.

| last2 = Ha | first2 = I.

| last3 = Ruvkun | first3 = G.

| title = Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. Elegans

| volume = 75

| issue = 5

| pages = 855–862

| journal = Cell

| doi = 10.1016/0092-8674(93)90530-4

| doi-access = free

}} In the same issue of Cell, Victor Ambros described the regulatory product of lin-4 as a small RNA.{{cite journal

| doi = 10.1016/0092-8674(93)90529-Y

| year = 1993

| title = The C. Elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

| journal = Cell

| volume = 75

| issue = 5

| pages = 843–854

| pmid = 8252621

| last1 = Lee | first1 = R. C.

| last2 = Feinbaum | first2 = R. L.

| last3 = Ambros | first3 = V.

| doi-access = free

}} These papers revealed a new world of RNA regulation at an unprecedented small size scale, and the mechanism of that regulation.{{Cite journal

| pmid = 1742500

| year = 1991

| last1 = Ruvkun

| first1 = G

| last2 = Wightman

| first2 = B

| last3 = Bürglin

| first3 = T

| last4 = Arasu

| first4 = P

| title = Dominant gain-of-function mutations that lead to misregulation of the C. Elegans heterochronic gene lin-14, and the evolutionary implications of dominant mutations in pattern-formation genes

| volume = 1

| pages = 47–54

| journal = Development. Supplement

}}{{Cite journal

| pmid = 2565854

| year = 1989

| last1 = Ruvkun | first1 = G.

| last2 = Ambros | first2 = V.

| last3 = Coulson | first3 = A.

| last4 = Waterston | first4 = R.

| last5 = Sulston | first5 = J.

| last6 = Horvitz | first6 = H. R.

| title = Molecular Genetics of the Caenorhabditis Elegans Heterochronic Gene Lin-14

| volume = 121

| issue = 3

| pages = 501–516

| pmc = 1203636

| journal = Genetics

| doi = 10.1093/genetics/121.3.501

}} Together, this research is now recognized as the first description of microRNAs and the mechanism by which partially base-paired miRNA::mRNA duplexes inhibit translation.{{Cite journal

| pmid = 15055593

| year = 2004

| last1 = Ruvkun | first1 = G.

| last2 = Wightman | first2 = B.

| last3 = Ha | first3 = I.

| title = The 20 years it took to recognize the importance of tiny RNAs

| volume = 116

| issue = 2 Suppl

| pages = S93–S96, 2 S96 following S96

| journal = Cell

| doi = 10.1016/S0092-8674(04)00034-0

| s2cid = 17490257

| doi-access = free

}}

In 2000, the Ruvkun lab reported the identification of second C. elegans microRNA, let-7, which like the first microRNA regulates translation of the target gene, in this case lin-41, via imperfect base pairing to the 3’ untranslated region of that mRNA.{{cite journal

| year = 2000

| title = The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

| journal = Nature

| volume = 403

| issue = 6772

| pages = 901–906

| pmid = 10706289

| last1 = Reinhart | first1 = B. J.

| last2 = Slack | first2 = F. J.

| last3 = Basson | first3 = M.

| last4 = Pasquinelli | first4 = A. E.

| last5 = Bettinger | first5 = J. C.

| last6 = Rougvie | first6 = A. E.

| last7 = Horvitz | first7 = H. R.

| last8 = Ruvkun | first8 = G.

| doi = 10.1038/35002607

|bibcode = 2000Natur.403..901R | s2cid = 4384503

}}{{cite journal

| doi = 10.1016/S1097-2765(00)80245-2

| year = 2000

| title = The lin-41 RBCC gene acts in the C. Elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor

| journal = Molecular Cell

| volume = 5

| issue = 4

| pages = 659–669

| pmid = 10882102

| last1 = Slack | first1 = F. J.

| last2 = Basson | first2 = M.

| last3 = Liu | first3 = Z.

| last4 = Ambros | first4 = V.

| last5 = Horvitz | first5 = H. R.

| last6 = Ruvkun | first6 = G.

| doi-access = free

}} This was an indication that miRNA regulation via 3’ UTR complementarity may be a common feature, and that there were likely to be more microRNAs. The generality of microRNA regulation to other animals was established by the Ruvkun lab later in 2000, when they reported that the sequence and regulation of the let-7 microRNA is conserved across animal phylogeny, including in humans.{{cite journal

| year = 2000

| title = Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA | first19 = E.

| last19 = Ruvkun | first18 = P.

| last18 = Davidson | first17 = M.

| last17 = Leahy | first16 = J.

| last16 = Levine | first15 = J.

| last15 = Corbo | first14 = M.

| last14 = Finnerty | first13 = A.

| last13 = Fishman | first12 = J. R.

| last12 = Srinivasan

| journal = Nature | first11 = P.

| volume = 408

| issue = 6808

| last11 = Spring

| pages = 86–89

| pmid = 11081512

| first10 = B.

| last1 = Pasquinelli | first1 = A. E.

| last2 = Reinhart | first2 = B. J.

| last3 = Slack

| last10 = Müller | first3 = F.

| last4 = Martindale | first4 = M. Q.

| last5 = Kuroda | first5 = M. I.

| last6 = Maller | first6 = B.

| last7 = Hayward | first7 = D. C.

| last8 = Ball | first8 = E. E.

| last9 = Degnan | first9 = B.

| doi = 10.1038/35040556 | bibcode = 2000Natur.408...86P

| s2cid = 4401732 }}

When siRNAs of the same 21-22 nucleotide size as lin-4 and let-7 were discovered in 1999 by Hamilton and Baulcombe in plants,{{Cite journal

| pmid = 10542148

| year = 1999

| last1 = Hamilton | first1 = A. J.

| last2 = Baulcombe | first2 = D. C.

| title = A species of small antisense RNA in posttranscriptional gene silencing in plants

| volume = 286

| issue = 5441

| pages = 950–952

| journal = Science

| doi=10.1126/science.286.5441.950

}} the fields of RNAi and miRNAs suddenly converged. It seemed likely that the similarly sized miRNAs and siRNAs would use similar mechanisms. In a collaborative effort, the Mello and Ruvkun labs showed that the first known components of RNA interference and their paralogs, Dicer and the PIWI proteins, are used by both miRNAs and siRNAs.{{Cite journal

| pmid = 11461699

| year = 2001

| last1 = Grishok | first1 = A.

| last2 = Pasquinelli | first2 = A. E.

| last3 = Conte | first3 = D.

| last4 = Li | first4 = N.

| last5 = Parrish | first5 = S.

| last6 = Ha | first6 = I.

| last7 = Baillie | first7 = D. L.

| last8 = Fire | first8 = A.

| last9 = Ruvkun | first9 = G.

| last10 = Mello | first10 = C. C.

| title = Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. Elegans developmental timing

| volume = 106

| issue = 1

| pages = 23–34

| journal = Cell

| doi = 10.1016/S0092-8674(01)00431-7

| s2cid = 6649604

| doi-access = free

}} Ruvkun's lab in 2003 identified many more miRNAs,{{Cite journal

| pmid = 12769849

| year = 2003

| last1 = Grad | first1 = Y.

| last2 = Aach | first2 = J.

| last3 = Hayes | first3 = G. D.

| last4 = Reinhart | first4 = B. J.

| last5 = Church | first5 = G. M.

| last6 = Ruvkun | first6 = G.

| last7 = Kim | first7 = J.

| title = Computational and experimental identification of C. Elegans microRNAs

| volume = 11

| issue = 5

| pages = 1253–1263

| journal = Molecular Cell

| doi = 10.1016/S1097-2765(03)00153-9

| doi-access = free

}}{{Cite journal

| doi = 10.1016/j.cub.2007.10.058

| pmid = 18023351

| year = 2007

| last1 = Parry | first1 = D.

| last2 = Xu | first2 = J.

| last3 = Ruvkun | first3 = G.

| title = A whole-genome RNAi Screen for C. Elegans miRNA pathway genes

| volume = 17

| issue = 23

| pages = 2013–2022

| pmc = 2211719

| journal = Current Biology

| bibcode = 2007CBio...17.2013P

}} identified miRNAs from mammalian neurons,{{Cite journal

| doi = 10.1073/pnas.2333854100

| pmid = 14691248

| year = 2004

| last1 = Kim | first1 = J.

| last2 = Krichevsky | first2 = A.

| last3 = Grad | first3 = Y.

| last4 = Hayes | first4 = G.

| last5 = Kosik | first5 = K.

| last6 = Church | first6 = G.

| last7 = Ruvkun | first7 = G.

| title = Identification of many microRNAs that copurify with polyribosomes in mammalian neurons

| volume = 101

| issue = 1

| pages = 360–365

| pmc = 314190

| journal = Proceedings of the National Academy of Sciences of the United States of America

|bibcode = 2004PNAS..101..360K | doi-access = free

}} and in 2007 discovered many new protein-cofactors for miRNA function.{{Cite journal

| doi = 10.1242/dev.02655

| pmid = 17065234

| year = 2006

| last1 = Hayes | first1 = G.

| last2 = Frand | first2 = A.

| last3 = Ruvkun | first3 = G.

| title = The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25

| volume = 133

| issue = 23

| pages = 4631–4641

| journal = Development

| doi-access = free

}}{{Cite journal

| doi = 10.1101/sqb.2006.71.018

| pmid = 17381276

| year = 2006

| last1 = Hayes | first1 = G.

| last2 = Ruvkun | first2 = G.

| title = Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs

| volume = 71

| pages = 21–27

| journal = Cold Spring Harbor Symposia on Quantitative Biology

| doi-access = free

}}{{Cite journal

| doi = 10.1111/j.1525-142X.2007.00217.x

| pmid = 18184361

| year = 2008

| last1 = Pierce | first1 = M.

| last2 = Weston | first2 = M.

| last3 = Fritzsch | first3 = B.

| last4 = Gabel | first4 = H.

| last5 = Ruvkun | first5 = G.

| last6 = Soukup | first6 = G.

| title = MicroRNA-183 family conservation and ciliated neurosensory organ expression

| volume = 10

| issue = 1

| pages = 106–113

| pmc = 2637451

| journal = Evolution & Development

}}

Ruvkun's laboratory has also discovered that an insulin-like signaling pathway controls C. elegans metabolism and longevity. Klass{{Cite journal

| doi = 10.1038/260523a0

| pmid = 1264206

| year = 1976

| last1 = Klass | first1 = M.

| last2 = Hirsh | first2 = D.

| title = Non-ageing developmental variant of Caenorhabditis elegans

| volume = 260

| issue = 5551

| pages = 523–525

| journal = Nature

|bibcode = 1976Natur.260..523K | s2cid = 4212418

}} Johnson{{Cite journal

| pmid = 8608934

| year = 1988

| last1 = Friedman | first1 = D. B.

| last2 = Johnson | first2 = T. E.

| title = A Mutation in the Age-1 Gene in Caenorhabditis Elegans Lengthens Life and Reduces Hermaphrodite Fertility

| volume = 118

| issue = 1

| pages = 75–86

| pmc = 1203268

| journal = Genetics

| doi = 10.1093/genetics/118.1.75

}} and Kenyon{{Cite journal

| doi = 10.1038/366461a0

| title = A C. Elegans mutant that lives twice as long as wild type

| pmid = 8247153

| year = 1993

| last1 = Kenyon | first1 = C.

| last2 = Chang | first2 = J.

| last3 = Gensch | first3 = E.

| last4 = Rudner | first4 = A.

| last5 = Tabtiang | first5 = R.

| journal = Nature

| volume = 366

| issue = 6454

| pages = 461–464

|bibcode = 1993Natur.366..461K | s2cid = 4332206

}} showed that the developmental arrest program mediated by mutations in age-1 and daf-2 increase C. elegans longevity. The Ruvkun lab established that these genes constitute an insulin like receptor and a downstream phosphatidylinositol kinase that couple to the daf-16 gene product, a highly conserved Forkhead transcription factor.{{cite journal |last1=Lee |first1=Siu Sylvia |last2=Kennedy |first2=Scott |last3=Tolonen |first3=Andrew C. |last4=Ruvkun |first4=Gary |title=DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism |journal=Science |date=25 April 2003 |volume=300 |issue=5619 |pages=644–647 |doi=10.1126/science.1083614|pmid=12690206 |bibcode=2003Sci...300..644L }} Homologues of these genes have now been implicated in regulation of human aging.{{Cite journal

| doi = 10.1038/nature08980

| pmid = 20336132

| title = The genetics of ageing

| year = 2010

| last1 = Kenyon | first1 = C. J.

| journal = Nature

| volume = 464

| issue = 7288

| pages = 504–512

|bibcode = 2010Natur.464..504K | s2cid = 2781311

}} These findings are also important for diabetes, since the mammalian orthologs of daf-16 (referred to as FOXO transcription factors) are also regulated by insulin.{{cite journal |last1=Kenyon |first1=Cynthia |title=The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing |journal=Philosophical Transactions of the Royal Society B: Biological Sciences |date=12 January 2011 |volume=366 |issue=1561 |pages=9–16 |doi=10.1098/rstb.2010.0276|pmid=21115525 |pmc=3001308 }} The Ruvkun lab has used full genome RNAi libraries to discover genes that regulate aging and metabolism. Many of these genes are broadly conserved in animal phylogeny and could be targeted in diabetes drug development.{{cite web |title=Gary Ruvkun, Ph.D. {{!}} Mass General Research Institute |url=https://researchers.mgh.harvard.edu/profile/4180915/Gary-Ruvkun |website=Mass General Research Institute |access-date=9 October 2024 |language=en}}

The Ruvkun lab in collaboration with Maria Zuber at MIT, Chris Carr (now at Georgia Tech), and Michael Finney (now a San Francisco biotech entrepreneur) has been developing protocols and instruments that can amplify and sequence DNA and RNA to search for life on another planet that is ancestrally related to the Tree of Life on Earth.{{cite web |last1=Ruvkun |first1=Gary |last2=Finney |first2=Michael |last3=Zuber |first3=Maria T. |last4=Carr |first4=Chris |last5=Church |first5=George M. |last6=Gilbert |first6=Walter |last7=Quake |first7=Stephen |last8=Mayer |first8=William F. |title=SETG, a Search for Extraterrestrial Genomes: An in situ PCR Detector for Life on Mars Ancestrally Related to Life on Earth |url=http://155.52.206.9/PDFs/ruvkun_SETG.pdf |access-date=9 October 2024 |archive-date=October 9, 2024 |archive-url=https://web.archive.org/web/20241009120257/http://155.52.206.9/PDFs/ruvkun_SETG.pdf |url-status=live }} The Search for Extraterrestrial Genomes, or SETG, project has been developing a small instrument that can determine DNA sequences on Mars (or any other planetary body), and send the information in those DNA sequence files to Earth for comparison to life on Earth.{{cite web |title=Overview ‹ Search for Extra-Terrestrial Genomes (SETG) — MIT Media Lab |url=https://www.media.mit.edu/projects/search-for-extra-terrestrial-genomes-setg/overview/ |website=MIT Media Lab |access-date=9 October 2024 |archive-date=November 30, 2023 |archive-url=https://web.archive.org/web/20231130014737/https://www.media.mit.edu/projects/search-for-extra-terrestrial-genomes-setg/overview/ |url-status=live }}

In 2012, Ruvkun made an original contribution to the field of immunology with the publication of a featured paper in the journal Cell describing an elegant mechanism for innate immune surveillance in animals that relies on the monitoring of core cellular functions in the host, which are often sabotaged by microbial toxins during the course of infection.{{Cite journal|last1=Melo|first1=Justine A.|last2=Ruvkun|first2=Gary|date=April 13, 2012|title=Inactivation of conserved C. elegans genes engages pathogen- and xenobiotic-associated defenses|journal=Cell|volume=149|issue=2|pages=452–466|doi=10.1016/j.cell.2012.02.050|issn=1097-4172|pmc=3613046|pmid=22500807}}

In 2019, Ruvkun, together with Chris Carr, Mike Finney and Maria Zuber,{{cite web |last=Ruvkun |first=Gary |author-link=Gary Ruvkun |title=YouTube Video (24:32) – Breakthrough Discuss 2019 – What is True for E. coli on Earth Will Be True for Life on Proxima Centauri b |url=https://www.youtube.com/watch?v=CFDPLkddRqE |date=April 17, 2019 |work=University of Berkeley |access-date=July 9, 2019 |archive-date=October 9, 2024 |archive-url=https://web.archive.org/web/20241009120350/https://www.youtube.com/watch?v=CFDPLkddRqE |url-status=live }} presented the argument that the appearance of sophisticated microbial life on Earth soon after it cooled, and the recent discoveries of hot Jupiters and disruptive planetary migrations in exoplanet systems favors the spread of DNA-based microbial life across the galaxy. The SETG project is working to have NASA send a DNA sequencer to Mars to search for life there in the hope that evidence will be uncovered that life did not arise originally on Earth, but elsewhere in the universe.{{cite magazine |last=Chotiner |first=Isaac |title=What If Life Did Not Originate on Earth? |url=https://www.newyorker.com/news/q-and-a/what-if-life-did-not-originate-on-earth |date=July 8, 2019 |magazine=The New Yorker |language=en |issn=0028-792X |access-date=July 9, 2019 |archive-date=March 21, 2020 |archive-url=https://web.archive.org/web/20200321113657/https://www.newyorker.com/news/q-and-a/what-if-life-did-not-originate-on-earth |url-status=live }}

As of 2018, Ruvkun has published about 150 scientific articles. Ruvkun has received numerous awards for his contributions to medical science, for his contributions to the aging field{{Cite web|url=http://www.dandavidprize.org/laureates/2011/94-future-ageing-facing-the-challenge/204-gary-ruvkun|title=Dan David Prize 10th Anniversary 2011 Laureates Announced: The Coen Brothers – for Cinema; Marcus Feldman – for Evolution; Cynthia Kenyon and Gary Ruvkun – for Ageing|website=www.newswire.ca|language=en|access-date=April 25, 2018|archive-date=April 21, 2018|archive-url=https://web.archive.org/web/20180421095459/http://www.dandavidprize.org/laureates/2011/94-future-ageing-facing-the-challenge/204-gary-ruvkun|url-status=live}} and to the discovery of microRNAs.[http://www.gairdner.org/awards/awardees2/2008/2008awarde/garyruvkun "Gary Ruvkun"] {{Webarchive|url=https://web.archive.org/web/20080512010804/http://www.gairdner.org/awards/awardees2/2008/2008awarde/garyruvkun |date=May 12, 2008 }} – The Gairdner Foundation (Retrieved on May 25, 2008) He is a recipient of the Lasker Award for Basic Medical Research,[http://www.laskerfoundation.org/press/pdf/2008pressrelease.pdf "Gary Ruvkun"] {{Webarchive|url=https://web.archive.org/web/20100716152939/http://www.laskerfoundation.org/press/pdf/2008pressrelease.pdf |date=July 16, 2010 }}– The Lasker Foundation (Retrieved on September 15, 2008) the Gairdner Foundation International Award, and the Benjamin Franklin Medal in Life Science.{{Cite web|url=http://www.fi.edu/franklinawards/08/laureate_bf_lifescience-ambros-baulcombe-ruvkin.html|archiveurl=https://web.archive.org/web/20080515075228/http://www.fi.edu/franklinawards/08/laureate_bf_lifescience-ambros-baulcombe-ruvkin.html|url-status=dead|title=Franklin Award|archivedate=May 15, 2008|accessdate=December 14, 2021}} Ruvkun was elected as a member of the National Academy of Sciences in 2008.{{cite web |title=Gary Ruvkun – NAS |url=https://www.nasonline.org/directory-entry/gary-ruvkun-2sybez/ |website=National Academy of Sciences |access-date=9 October 2024}}

File:Genetics laureates.jpg alongside Victor Ambros in 2014.]]

• 2004 Rosenstiel Award for Distinguished Work in Medical Research of Brandeis University (co-recipient with Craig Mello, Andrew Fire and Victor Ambros){{Cite web |title=Rosenstiel Award Winners |url=https://www.brandeis.edu/rosenstiel/rosenstiel-award/past.html |publisher=Brandeis University |access-date=October 7, 2024 |archive-date=August 4, 2017 |archive-url=https://web.archive.org/web/20170804105015/http://www.brandeis.edu/rosenstiel/rosenstielaward/past.html |url-status=live }}
• 2008 Warren Triennial Prize, Massachusetts General Hospital (co-recipient with Victor Ambros){{cite web |title=Warren Triennial Prize |author1=MGH Executive Committee on Research |url=https://ecor.mgh.harvard.edu/MeetingsEvents/warren-triennial-prize |access-date=9 October 2024}}
• 2008 Gairdner Foundation International Award (co-recipient with Victor Ambros){{cite web |title=Gary Ruvkun - Gairdner Foundation Award Winner |url=https://www.gairdner.org/winner/gary-ruvkun |website=The Gairdner Foundation |access-date=9 October 2024 |language=en |date=7 October 2024}}
• 2008 Benjamin Franklin Medal in Life Science (co-recipient with Victor Ambros and David Baulcombe){{cite web |last1=Morrison |first1=Mike |title=Mass General Hospital researcher Gary Ruvkun honored with 2024 Nobel Prize |url=https://www.massgeneral.org/news/press-release/mgh-researcher-gary-ruvkun-honored-with-2024-nobel-prize |website=Massachusetts General Hospital |access-date=9 October 2024 |date=7 October 2024}}
• 2008 Lasker Foundation Award for Basic Medical Research (co-recipient with Victor Ambros and David Baulcombe)
• 2008 Elected to the National Academy of Sciences
• 2009 Louisa Gross Horwitz Prize, Columbia University (co-recipient with Victor Ambros){{cite web |title=2010 - 2001 Awardees |url=https://www.cuimc.columbia.edu/research/louisa-gross-horwitz-prize/horwitz-prize-awardees/2010-2001-awardees |website=Columbia University Irving Medical Center |access-date=9 October 2024 |language=en |date=11 November 2022}}
• 2009 American Academy of Arts and Sciences{{cite web |title=Gary B. Ruvkun {{!}} American Academy of Arts and Sciences |url=https://www.amacad.org/person/gary-b-ruvkun |website=American Academy of Arts & Sciences |access-date=9 October 2024 |language=en |date=9 October 2024}}
• 2009 Massry Prize from the Keck School of Medicine, University of Southern California (co-recipient with Victor Ambros){{cite web |title=Past Laureates |url=https://keck2.usc.edu/massry-prize/past-laureates |website=Massry Prize |access-date=9 October 2024}}
• 2009 Institute of Medicine{{cite web |title=Center for Computational and Integrative Biology |url=https://ccib.mgh.harvard.edu/ruvkun |access-date=9 October 2024}}
• 2011 The International Dan David Prize, awarded by Tel Aviv University, Israel (co-recipient with Cynthia Kenyon)
• 2012 Dr. Paul Janssen Award for Biomedical Research with Victor Ambros
• 2014 Wolf Prize for Medicine (co-recipient with Victor Ambros)
• 2015 Breakthrough Prize in Life Sciences (co-recipient with C. David Allis, Victor Ambros, Alim Louis Benabid, Jennifer A. Doudna and Emmanuelle Charpentier).
• 2016 March of Dimes Prize in Developmental Biology (co-recipient with Victor Ambros){{cite web|url=http://www.umassmed.edu/news/news-archives/2016/05/victor-ambros-awarded-2016-march-of-dimes-prize-for-co-discovery-of-micrornas/|title=Victor Ambros awarded 2016 March of Dimes prize for co-discovery of MicroRNAs|publisher=University of Massachusetts Medical School|access-date= September 9, 2016|date=May 3, 2016|archive-date=July 22, 2024|archive-url=https://web.archive.org/web/20240722142929/https://www.umassmed.edu/news/news-archives/2016/05/victor-ambros-awarded-2016-march-of-dimes-prize-for-co-discovery-of-micrornas/|url-status=live}}
• 2023 Highly Ranked Scholar by ScholarGPS {{Cite web|url=https://scholargps.com/scholars/42472098479047/gary-ruvkun |title=ScholarGPS Profile: Gary Ruvkun |access-date=October 9, 2024 |archive-date=October 9, 2024 |archive-url=https://web.archive.org/web/20241009120317/https://scholargps.com/scholars/42472098479047/gary-ruvkun |url-status=live }}
• 2024 Nobel Prize in Physiology or Medicine (co-recipient with Victor Ambros)

• List of Jewish Nobel laureates

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{{Scholia}}

• {{Nobelprize}}
• [https://www.ruvkun.hms.harvard.edu/ RUVKUN LAB]
• [https://molbio.massgeneral.org/labs/ruvkun-lab/ Ruvkun Lab]
• [https://genetics.hms.harvard.edu/faculty-staff/gary-b-ruvkun Harvard Medical School faculty page]
• {{youTube|CFDPLkddRqE|Video (24:32): “Migration of Life in the Universe”}} – Gary Ruvkun, 2019.

{{Nobel Prize in Physiology or Medicine}}

{{2024 Nobel Prize winners}}

{{Breakthrough Prize laureates}}

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Category:Living people

Category:American geneticists

Category:Biogerontologists

Category:Harvard Medical School faculty

Category:Recipients of the Albert Lasker Award for Basic Medical Research

Category:Members of the United States National Academy of Sciences

Category:1952 births

Category:Massry Prize recipients

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Category:University of California, Berkeley alumni

Category:Members of the American Philosophical Society

Category:Members of the National Academy of Medicine

Category:Benjamin Franklin Medal (Franklin Institute) laureates

Category:Scientists from Berkeley, California

Category:Jewish American scientists

Category:American Nobel laureates

Category:Nobel laureates in Physiology or Medicine