Gerhard Ecker
{{Short description|Austrian medicinal chemist}}
{{Infobox scientist
| name = Gerhard F. Ecker
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| birth_place = Seitenstetten
| nationality = Austrian
| fields =
| workplaces = University of Vienna
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| known_for = Medicinal Chemistry
Pharmacoinformatics
Open PHACTS{{Cite journal | last1 = Williams | first1 = A. J. | author-link1 = Antony John Williams| last2 = Harland | first2 = L. | last3 = Groth | first3 = P. | last4 = Pettifer | first4 = S. | author-link4 = Steve Pettifer| last5 = Chichester | first5 = C. | last6 = Willighagen | first6 = E. L. | last7 = Evelo | first7 = C. T. | last8 = Blomberg | first8 = N. | last9 = Ecker | first9 = G. | author-link9 = Gerhard Ecker| last10 = Goble | first10 = C. | author-link10 = Carole Goble| last11 = Mons | first11 = B. | author-link11 = Barend Mons| title = Open PHACTS: Semantic interoperability for drug discovery | doi = 10.1016/j.drudis.2012.05.016 | journal = Drug Discovery Today| volume = 17 | issue = 21–22 | pages = 1188–1198 | year = 2012 | pmid = 22683805 | doi-access = free | url = https://cris.maastrichtuniversity.nl/files/65578679/willighagen_2012_open_PHACTS_semantic_interoperabilit.pdf }}
| website = {{URL|https://pharminfo.univie.ac.at/}}
}}
Gerhard F. Ecker is an Austrian medicinal chemist and expert in the fields of Pharmacoinformatics at the University of Vienna, where he is the Professor for Pharmacoinformatics and Head of the [http://pharminfo.univie.ac.at Pharmacoinformatics Research Group] at the Department of Medicinal Chemistry. He also coordinates the research focus "Computational Life Sciences" of the Faculty of Life Sciences.
Career
Ecker received his doctorate in natural sciences from the University of Vienna in 1991,His university-hosted CV - {{cite web |url=http://homepage.univie.ac.at/gerhard.f.ecker/ecker_cv.htm |title=Gerhard Ecker Home |access-date=2011-12-07 |url-status=dead |archive-url=https://web.archive.org/web/20110918023636/http://homepage.univie.ac.at/gerhard.f.ecker/ecker_cv.htm |archive-date=2011-09-18 }} - this cross-references with his publications on Google Scholar: https://scholar.google.com/scholar?as_q=&as_sauthors=Gerhard+Ecker+Fleischhacker+Noe became appointed Associate Professor for Medicinal Chemistry in 1998 and Full Professor for Pharmacoinformatics in 2009.Bio from wiley.com - for Transporters as Drug Carriers: Structure, Function, Substrates, Volume 44 - http://onlinelibrary.wiley.com/book/10.1002/9783527627424/homepage/AuthorBiography.html
Ecker is Editor of Molecular Informatics[http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291868-1751 Molecular Informatics] and coordinates the EUROPIN PhD programme in Pharmacoinformatics.{{citation needed|date=November 2011}} Currently he is also President of the European Federation for Medicinal Chemistry.[http://www.efmc.info/committee.php?langue=english&cle_menus=1110301009 European Federation for Medicinal Chemistry]
Research
Ecker's research focuses on computational drug design which not only led to the identification of highly active propafenone-type inhibitors of P-glycoprotein,{{Cite journal | last1 = Jabeen | first1 = I. | last2 = Wetwitayaklung | first2 = P. | last3 = Klepsch | first3 = F. | last4 = Parveen | first4 = Z. | last5 = Chiba | first5 = P. | last6 = Ecker | first6 = G. F. | s2cid = 205756984 | author-link6 = Gerhard Ecker| doi = 10.1039/C0CC03075A | title = Probing the stereoselectivity of P-glycoprotein—synthesis, biological activity and ligand docking studies of a set of enantiopure benzopyrano\3,4-b]\1,4]oxazines | journal = Chemical Communications | volume = 47 | issue = 9 | pages = 2586–2588 | year = 2011 | pmid = 21173990}}{{Cite journal | last1 = Sugano | first1 = K. | last2 = Kansy | first2 = M. | last3 = Artursson | first3 = P. | last4 = Avdeef | first4 = A. | last5 = Bendels | first5 = S. | last6 = Di | first6 = L. | last7 = Ecker | first7 = G. F.| author-link7 = Gerhard Ecker | last8 = Faller | first8 = B. | last9 = Fischer | first9 = H. | last10 = Gerebtzoff | doi = 10.1038/nrd3187 | first10 = G. G. | last11 = Lennernaes | first11 = H. | last12 = Senner | first12 = F. | title = Coexistence of passive and carrier-mediated processes in drug transport | journal = Nature Reviews Drug Discovery | volume = 9 | issue = 8 | pages = 597–614 | year = 2010 | pmid = 20671764| s2cid = 34829942 }}{{Cite journal | last1 = Klepsch | first1 = F. | last2 = Ecker | first2 = G. F. | author-link2 = Gerhard Ecker| doi = 10.1002/minf.201000017 | title = Impact of the Recent Mouse P-Glycoprotein Structure for Structure-Based Ligand Design | journal = Molecular Informatics | volume = 29 | issue = 4 | pages = 276–86 | year = 2010 | pmid = 27463054| pmc =6422301 }} but also paved the way for development of new descriptors and virtual screening approaches for identification of new scaffolds active at P-gp. With the increasing knowledge on the importance of P-gp for ADME, his interest moved towards the prediction of P-gp substrate properties.{{Cite journal | last1 = Parveen | first1 = Z. | last2 = Stockner | first2 = T. | last3 = Bentele | first3 = C. | last4 = Pferschy | first4 = S. | last5 = Kraupp | first5 = M. | last6 = Freissmuth | first6 = M. | last7 = Ecker | first7 = G. F. | author-link7 = Gerhard Ecker| last8 = Chiba | first8 = P. | doi = 10.1124/mol.110.067611 | title = Molecular Dissection of Dual Pseudosymmetric Solute Translocation Pathways in Human P-Glycoprotein | journal = Molecular Pharmacology | volume = 79 | issue = 3 | pages = 443–452 | year = 2010 | pmid = 21177413| pmc =6422312 }} Around 2010 he extended the studies also on other antitargets, such as the hERG potassium channel,{{Cite journal | last1 = Thai | first1 = K. M. | last2 = Windisch | first2 = A. | last3 = Stork | first3 = D. | last4 = Weinzinger | first4 = A. | last5 = Schiesaro | first5 = A. | last6 = Guy | first6 = R. H. | last7 = Timin | first7 = E. N. | last8 = Hering | first8 = S. | last9 = Ecker | first9 = G. F. | author-link9 = Gerhard Ecker| doi = 10.1002/cmdc.200900374 | title = The hERG Potassium Channel and Drug Trapping: Insight from Docking Studies with Propafenone Derivatives | journal = ChemMedChem | volume = 5 | issue = 3 | pages = 436–442 | year = 2010 | pmid = 20146282| s2cid = 23597808 }} as well as on the serotonin transporter,{{Cite journal | last1 = Sarker | first1 = S. | last2 = Weissensteiner | first2 = R. | last3 = Steiner | first3 = I. | last4 = Sitte | first4 = H. H. | last5 = Ecker | first5 = G. F. | author-link5 = Gerhard Ecker| last6 = Freissmuth | first6 = M. | last7 = Sucic | first7 = S. | doi = 10.1124/mol.110.067538 | title = The High-Affinity Binding Site for Tricyclic Antidepressants Resides in the Outer Vestibule of the Serotonin Transporter | journal = Molecular Pharmacology | volume = 78 | issue = 6 | pages = 1026–1035 | year = 2010 | pmid = 20829432| pmc = 4513247}} the GABA receptor{{Cite journal | last1 = Khom | first1 = S. | last2 = Strommer | first2 = B. | last3 = Ramharter | first3 = J. | last4 = Schwarz | first4 = T. | last5 = Schwarzer | first5 = C. | last6 = Erker | first6 = T. | last7 = Ecker | first7 = G. F. | author-link7 = Gerhard Ecker| last8 = Mulzer | first8 = J. | last9 = Hering | first9 = S. | doi = 10.1111/j.1476-5381.2010.00865.x | title = Valerenic acid derivatives as novel subunit-selective GABAA receptor ligands -in vitro and in vivo characterization | journal = British Journal of Pharmacology | volume = 161 | issue = 1 | pages = 65–78 | year = 2010 | pmid = 20718740| pmc =2962817 }} and the insulin receptor.{{PubMedAuthorSearch|Ecker|GF}}
References
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Category:Austrian pharmacologists
Category:Academic staff of the University of Vienna