OpenPHACTS

{{short description|Drug discovery organization}}

{{Infobox organization

| name = Open PHACTS

| image =

| image_border =

| size = frameless

| caption =

| map =

| msize =

| mcaption =

| abbreviation =

| motto =

| formation = 2011

| extinction =

| type = Public–private partnership

| status =

| purpose = Semantic interoperability for drug discovery through Open innovation

| headquarters =

| location =

| coords =

| region_served =

| membership = 27 member organisations

| leader_title =

| leader_name =

| main_organ =

| parent_organization =

| affiliations =

| num_staff =

| num_volunteers =

| budget =

| key_people = {{Plainlist|

| website = {{Plainlist|

  • {{URL|www.openphacts.org}}
  • {{URL|https://github.com/openphacts}}}}

| remarks =

}}

Open PHACTS (Open Pharmacological Concept Triple Store) was a European initiative public–private partnership between academia, publishers, enterprises, pharmaceutical companies and other organisations working to enable better, cheaper and faster drug discovery.{{Cite journal | last1 = Williams | first1 = A. J. | author-link1 = Antony John Williams| last2 = Harland | first2 = L. | last3 = Groth | first3 = P. | last4 = Pettifer | first4 = S. | author-link4 = Steve Pettifer| last5 = Chichester | first5 = C. | last6 = Willighagen | first6 = E. L. | last7 = Evelo | first7 = C. T. | last8 = Blomberg | first8 = N. | last9 = Ecker | first9 = G. | author-link9 = Gerhard Ecker| last10 = Goble | first10 = C. | author-link10 = Carole Goble| last11 = Mons | first11 = B. | author-link11 = Barend Mons| title = Open PHACTS: Semantic interoperability for drug discovery | doi = 10.1016/j.drudis.2012.05.016 | journal = Drug Discovery Today| volume = 17 | issue = 21–22 | pages = 1188–1198 | year = 2012 | pmid = 22683805 | doi-access = free }}{{Cite journal | last1 = Ecker | first1 = G. F. | last2 = Williams-Jones | first2 = B. | doi = 10.1002/minf.201280004 | title = Open Innovation in Drug Discovery | journal = Molecular Informatics| volume = 31 | issue = 8 | pages = 519–520 | year = 2012 | pmid = 27477598 | doi-access = free }}{{Cite journal| first1 = Alasdair J.G. | last1 = Gray| first2 = Paul |last2 = Groth| first3 = Antonis | last3 = Loizou| first4 = Sune | last4 = Askjaer| first5 = Christian | last5 = Brenninkmeijer| first6 = Kees | last6 = Burger| first7 = Christine| last7 = Chichester| first8 = Chris T. | last8 = Evelo| first9 = Carole | last9 = Goble| author-link9 = Carole Goble| first10 = Lee | last10 = Harland| first11 = Steve| last11 = Pettifer| author-link11 = Steve Pettifer| first12 = Mark| last12 = Thompson| first13 = Andra| last13 = Waagmeester| first14 = Antony John| last14 = Williams| author-link14 = Antony John Williams| doi=10.3233/SW-2012-0088| title = Applying linked data approaches to pharmacology: Architectural decisions and implementation| journal = Semantic Web| volume = 5 | issue = 2| pages = 101–113| year = 2014 | arxiv = 1005.2643}}{{Cite journal| pmid = 24267948| year = 2013| last1 = Ciccarese| first1 = P| title = PAV ontology: Provenance, authoring and versioning| journal = Journal of Biomedical Semantics| volume = 4| issue = 1| pages = 37| last2 = Soiland-Reyes| first2 = S| last3 = Belhajjame| first3 = K| last4 = Gray| first4 = A. J.| last5 = Goble| first5 = C| last6 = Clark| first6 = T| doi = 10.1186/2041-1480-4-37| arxiv = 1304.7224| pmc=4177195| doi-access = free}} It has been funded by the Innovative Medicines Initiative,{{cite web |url=http://www.imi.europa.eu/content/open-phacts |title=Open PHACTS at IMI - The Innovative Medicines Initiative }} selected as part of three projects to "design methods for common standards and sharing of data for more efficient drug development and patient treatment in the future".{{Cite journal | last1 = Watson | first1 = R. | doi = 10.1136/bmj.d1577 | title = Europe provides €172m for research into innovative medicines | journal = BMJ | volume = 342 | pages = d1577 | year = 2011 | pmid = 21393337| s2cid = 40608990 }}{{Cite book | doi = 10.1007/978-3-642-41338-4_5| chapter = Incorporating Commercial and Private Data into an Open Linked Data Platform for Drug Discovery| title = Advanced Information Systems Engineering| volume = 8219| pages = 65–80| series = Lecture Notes in Computer Science| year = 2013| last1 = Goble | first1 = C. | author-link1 = Carole Goble| last2 = Gray | first2 = A. J. G. | last3 = Harland | first3 = L. | last4 = Karapetyan | first4 = K. | last5 = Loizou | first5 = A. | last6 = Mikhailov | first6 = I. | last7 = Rankka | first7 = Y. N. | last8 = Senger | first8 = S. | last9 = Tkachenko | first9 = V. | last10 = Williams | first10 = A. J. | author-link10 = Antony John Williams| last11 = Willighagen | first11 = E. L. | isbn = 978-3-642-41337-7}}

Partnerships

Drug discovery

The Open Pharmacological Space created by the consortium intended to support open innovation and in-house non-public drug discovery research{{Cite journal

| last1 = Müller | first1 = S.

| last2 = Weigelt | first2 = J.

| title = Open-access public-private partnerships to enable drug discovery--new approaches

| journal = IDrugs: The Investigational Drugs Journal

| volume = 13

| issue = 3

| pages = 175–180

| year = 2010

| pmid = 20191434

}} by removing bottlenecks in drug development.{{Cite journal

| last1 = Dalgleish | first1 = R.

| last2 = Molero | first2 = E.

| last3 = Kidd | first3 = R.

| last4 = Jansen | first4 = M.

| last5 = Past | first5 = D.

| last6 = Robl | first6 = A.

| last7 = Mons | first7 = B.

| last8 = Diaz | first8 = C.

| last9 = Mons | first9 = A.

| last10 = Brookes | first10 = A. J.

| title = Solving bottlenecks in data sharing in the life sciences

| doi = 10.1002/humu.22123

| journal = Human Mutation

| volume = 33

| issue = 10

| pages = 1494–1496

| year = 2012

| pmid = 22623360

| doi-access = free

}}{{Cite journal | last1 = Mons | first1 = B. | author-link1 = Barend Mons| last2 = Van Haagen | first2 = H. | last3 = Chichester | first3 = C. | last4 = Hoen | first4 = P. B. 'T. | last5 = Den Dunnen | first5 = J. T. | last6 = Van Ommen | first6 = G. | last7 = Van Mulligen | first7 = E. | last8 = Singh | first8 = B. | last9 = Hooft | first9 = R. | last10 = Roos | doi = 10.1038/ng0411-281 | first10 = M. | last11 = Hammond | first11 = J. | last12 = Kiesel | first12 = B. | last13 = Giardine | first13 = B. | last14 = Velterop | first14 = J. | author-link14 = Jan Velterop| last15 = Groth | first15 = P. | last16 = Schultes | first16 = E. | title = The value of data | journal = Nature Genetics | volume = 43 | issue = 4 | pages = 281–283 | year = 2011 | pmid = 21445068| doi-access = free }} Resources from the project are publicly available on GitHub.{{cite web |url=https://github.com/openphacts |title=Open PHACTS on GitHub |website=GitHub |access-date=2012-07-10}}

To reduce the barriers to drug discovery in industry, academia and for small businesses, the Open PHACTS consortium built the Open PHACTS Discovery Platform. This platform was freely available, integrating pharmacological data from a variety of information resources and providing tools and services to question this integrated data to support pharmacological research.

References