HBQ1
{{Short description|Mammalian protein found in Homo sapiens}}
{{Infobox_gene}}
Hemoglobin subunit theta-1 is a protein that in humans is encoded by the HBQ1 gene.{{cite journal | vauthors = Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ | title = A review of the molecular genetics of the human alpha-globin gene cluster | journal = Blood | volume = 73 | issue = 5 | pages = 1081–104 |date=May 1989 | pmid = 2649166 | doi = 10.1182/blood.V73.5.1081.1081| doi-access = free }}{{cite web | title = Entrez Gene: HBQ1 hemoglobin, theta 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3049}}
Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue.{{cite web | title = Entrez Gene: HBQ1 hemoglobin, theta 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3049}}
References
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Further reading
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- {{cite journal |vauthors=Giardina B, Messana I, Scatena R, Castagnola M |title=The multiple functions of hemoglobin. |journal=Crit. Rev. Biochem. Mol. Biol. |volume=30 |issue= 3 |pages= 165–96 |year= 1995 |pmid= 7555018 |doi=10.3109/10409239509085142 }}
- {{cite journal |vauthors=Kim JH, Yu CY, Bailey A, etal |title=Unique sequence organization and erythroid cell-specific nuclear factor-binding of mammalian theta 1 globin promoters. |journal=Nucleic Acids Res. |volume=17 |issue= 14 |pages= 5687–700 |year= 1989 |pmid= 2569721 |doi=10.1093/nar/17.14.5687 | pmc=318189 }}
- {{cite journal |vauthors=Ley TJ, Maloney KA, Gordon JI, Schwartz AL |title=Globin gene expression in erythroid human fetal liver cells. |journal=J. Clin. Invest. |volume=83 |issue= 3 |pages= 1032–8 |year= 1989 |pmid= 2921315 |doi=10.1172/JCI113944 | pmc=303780 }}
- {{cite journal |vauthors=Gonzalez-Redondo JM, Han IS, Gu YC, Huisman TH |title=Nucleotide sequence of the human theta 1-globin gene. |journal=Biochem. Genet. |volume=26 |issue= 3–4 |pages= 207–11 |year= 1988 |pmid= 3408475 |doi=10.1007/BF00561460 |s2cid=19352648 }}
- {{cite journal |vauthors=Hsu SL, Marks J, Shaw JP, etal |title=Structure and expression of the human theta 1 globin gene |journal=Nature |volume=331 |issue= 6151 |pages= 94–6 |year= 1988 |pmid= 3422341 |doi= 10.1038/331094a0 |bibcode=1988Natur.331...94H |s2cid=4357357 }}
- {{cite journal |vauthors=Daniels RJ, Peden JF, Lloyd C, etal |title=Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16 |journal=Hum. Mol. Genet. |volume=10 |issue= 4 |pages= 339–52 |year= 2001 |pmid= 11157797 |doi=10.1093/hmg/10.4.339 |doi-access=free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=De Gobbi M, Viprakasit V, Hughes JR, etal |title=A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter |journal=Science |volume=312 |issue= 5777 |pages= 1215–7 |year= 2006 |pmid= 16728641 |doi= 10.1126/science.1126431 |bibcode=2006Sci...312.1215D |s2cid=16044469 }}
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{{Hemeproteins}}
{{gene-16-stub}}